Duloxetine as an antidepresant characterized by a strong effect on cronic pain has a wide pespective of use in many cases, such as comorbid states frequently seen in population of elder patients. as a case report we are going to present an 81 years of age depressive woman patient suffered from cronic pain, with multiple somatic comorbidity: hipertension, stenosis of aortal valve, diabetes mellitus with late complications such as diabetical nephropathy, retinopathy, polineuropathy and amputed right leg; cataracta. She was depressed for a long time, in spite of using of many SSRI's and combinations of them; sometimes angry, but mostly without a will for life. She reacted positive on duloxetine and after six months of use of it there is a drastic diferrence in her affection, she was satisfied with her life, motivated to go on. in the same time, with a synerguc antihypertensive and antidibetic drugs we achieved stabile blood pression and serum glycaemia for a long period which was very difficult to achieve before the use of duloxetine. the self-perception of quality of life was examined by Short Form (36) Questionnaire of Quality of Life (SF-36) which showed beter results, i.e.patients' self-perception of quality of life after six months of use of duloxetine than at baseline.