Poison ivy is a virulent weed that is frequently treated with herbicides. Dicamba, 2,4-D, and two fixed-ratio tank mixtures of dicamba plus 2,4-D were evaluated across a series of rates for poison ivy control. Objective was to test whether tank mixtures were more effective than either herbicide applied alone. Dicamba alone, 2,4-D alone, a 1 : 3, and a 3 : 1 ratio (by weight) mixture of dicamba plus 2,4-D, respectively, were applied at eight rates to 2-yr-old, container-grown poison ivy plants. The eight rates ranged from 0.036 to 1.79 kg ae ha−1, which, in terms of phytotoxicity, generally ranged from none to death. Percentage of control was determined from plant fresh-weight reduction relative to a nontreated control and was determined at 1 and 4 mo after treatment (MAT). Rates required for 95% control at 1 MAT and for control of regrowth at 4 MAT and the cost of those treatments were determined for the dicamba and 2,4-D applied alone and in the two mixtures. At the 1-MAT evaluation, 2,4-D alone was more cost effective than either dicamba alone or the two mixtures. By the 4-MAT evaluation, however, which followed clipping at 3 MAT, dicamba alone was more cost effective than either mixture. The 2,4-D alone failed to provide 95% control at the 4 MAT evaluation, even at the highest rate evaluated (1.79 kg ha−1). Response curves for the two mixtures were equivalent to the response curves of the components applied alone at the 1 MAT evaluation and fell between the response curves of the components at the 4 MAT evaluation. Hence, 2,4-D plus dicamba mixtures were neither antagonistic nor synergistic. Results indicate that dicamba applied alone is far more effective than 2,4-D is for control of established and perennial poison ivy, assuming the intent is to obtain control with a single, one-time application.