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37 results

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  • Mechanisms of Action of Neural Grafts in the Limbic System
  • György Buzsáki, Fred H. Gage
  • Journal: Canadian Journal of Neurological Sciences / Volume 15 / Issue 2 / May 1988
  • Published online by Cambridge University Press: 18 September 2015, pp. 99-105
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  • View abstract

    This review summarizes the range of possible mechanisms of action of neuronal grafts in the central nervous system. It aims to illustrate the capacity and limitations of the transplanted tissue in the promotion of neurological recovery after experimental surgical insults.

  • Neuronal Replacement After Traumatic or Age-Dependent Brain Damage: A Review of Experimental Work in Rodents and its Clinical Implications
  • Anders Björklund, Fred H. Gage
  • Journal: International Journal of Technology Assessment in Health Care / Volume 1 / Issue 1 / January 1985
  • Published online by Cambridge University Press: 10 March 2009, pp. 93-107
  • View extract

    During the last few years evidence has accumulated that fetal neurons, implanted into the depth of the brain in adult rats, can reestablish damaged connections in the host brain and substitute functionally for elements lost or damaged as a result of a preceding lesion. This research work has led to the realization that, contrary to traditional views, the adult mammalian CNS has a potential to incorporate new neuronal elements into already established neuronal circuitry and that such implanted neurons can modify the function and behavior of the recipient. For a long time it was thought that the remarkable regenerative and functional potential of CNS tissue grafts that had been demonstrated in cold-blooded vertebrates reflected a fundamental difference in the regenerative properties of central nervous tissue between cold-blooded vertebrates and mammals. During the last few years it has become evident however, that at least certain types of intracerebral neural grafts can perfoum just as well in developing and mammals as in developing or adult submammalian vertebrates.

Textbook of Neural Repair and Rehabilitation
  • Textbook of Neural Repair and Rehabilitation
  • Volume 2, Medical Neurorehabilitation
  • Edited by Michael Selzer, Stephanie Clarke, Leonardo Cohen, Pamela Duncan, Fred Gage
  • Published online: 04 August 2010
  • Print publication: 16 February 2006
  • View description
    In two freestanding but linked volumes, Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. This volume, Medical Neurorehabilitation, can stand alone as a clinical handbook for neurorehabilitation. It covers the practical applications of the basic science principles presented in volume 1, provides authoritative guidelines on the management of disabling symptoms, and describes comprehensive rehabilitation approaches for the major categories of disabling neurological disorders. Emphasizing the integration of basic and clinical knowledge, this book and its companion are edited and written by leading international authorities. Together they are an essential resource for neuroscientists and provide a foundation for the work of clinical neurorehabilitation professionals .
  • Neural repair and rehabilitation: an introduction
  • Edited by Michael Selzer, University of Pennsylvania, Stephanie Clarke, Université de Lausanne, Switzerland, Leonardo Cohen, National Institute of Mental Health, Bethesda, Maryland, Pamela Duncan, University of Florida, Fred Gage, Salk Institute for Biological Studies, San Diego
  • Book: Textbook of Neural Repair and Rehabilitation
  • Published online: 04 August 2010
  • Print publication: 16 February 2006, pp xxvii-xxxvi
  • View extract

    Summary

    Among medical specialties, rehabilitation has been one of the slowest to develop a basic science framework and to establish evidence-based practices as its norms. The reasons for this relate in part to the urgent need for clinical service and the dearth of experienced practitioners in the field during its formative years. It is imperative now, that the perceived lack of a scientific basis be reversed in order for rehabilitation medicine to achieve its full academic recognition and fulfill its great potential for relieving human suffering. This book represents an attempt to place the practice of neurorehabilitation in a rigorous scientific framework. Precisely because the need and the potential are so great, the editors have devoted equal space and emphasis to the clinical practice of neurorehabilitation and to its basic science underpinnings. In particular, two areas of basic science are highlighted – neuroplasticity and neural repair. In this respect, the book differs from most clinical textbooks. However, the professional neurorehabilitation community has been especially supportive of this direction and has taken very active steps to further the development of a basic scientific underpinning for its field. Similarly, the field of rehabilitation medicine, and in particular neurorehabilitation, has begun to put great emphasis on the development of evidence-based medical practices (DeLisa et al., 1999; Ottenbacher and Maas, 1999; Practice PPoE-B, 2001). The chapters in the clinical sections of this book stress those therapies for which evidence exists based on controlled clinical trials.

Textbook of Neural Repair and Rehabilitation
  • Textbook of Neural Repair and Rehabilitation
  • Volume 1, Neural Repair and Plasticity
  • Edited by Michael Selzer, Stephanie Clarke, Leonardo Cohen, Pamela Duncan, Fred Gage
  • Published online: 05 March 2012
  • Print publication: 16 February 2006
  • View description
    In two freestanding volumes, Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. This volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal CNS, mechanisms of neuronal death, axonal regeneration, stem cell biology, and neuron replacement. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.

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