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The use of antidepressant drugs in patients with ischaemic heart disease
(IHD) has been debated owing to scarcity of data and conflicting results
regarding the effect of these drugs on mortality.
To evaluate the association between adherence to antidepressant therapy
and all-cause mortality in a population-based cohort of patients with
A total of 63 437 patients with IHD who purchased antidepressants at
least once during the years 2008–2011 were retrospectively followed for
all-cause mortality over 4 years. Adherence was measured as a ratio
between claimed and prescribed durations of medication and modelled as
non-adherence (<20%), poor (20–50%), moderate (50–80%) and good
(>80%). We used multivariable survival analyses adjusted for
demographic and clinical variables that may affect mortality.
The moderate and good adherence groups had significantly reduced adjusted
mortality hazard ratios of 0.83 (95% CI 0.78–0.88) and 0.86 (95% CI
0.82–0.90) respectively, compared with the non-adherence group.
Adherence to antidepressant pharmacotherapy is associated with reduced
all-cause mortality in a population-based large sample cohort of patients
with IHD. Physicians and health policy decision-makers should step up
their efforts to sustain and enhance these patients' adherence to their
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