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Healthcare personnel (HCP) were recruited to provide serum samples, which were tested for antibodies against Ebola or Lassa virus to evaluate for asymptomatic seroconversion.
From 2014 to 2016, 4 patients with Ebola virus disease (EVD) and 1 patient with Lassa fever (LF) were treated in the Serious Communicable Diseases Unit (SCDU) at Emory University Hospital. Strict infection control and clinical biosafety practices were implemented to prevent nosocomial transmission of EVD or LF to HCP.
All personnel who entered the SCDU who were required to measure their temperatures and complete a symptom questionnaire twice daily were eligible.
No employee developed symptomatic EVD or LF. EVD and LF antibody studies were performed on sera samples from 42 HCP. The 6 participants who had received investigational vaccination with a chimpanzee adenovirus type 3 vectored Ebola glycoprotein vaccine had high antibody titers to Ebola glycoprotein, but none had a response to Ebola nucleoprotein or VP40, or a response to LF antigens.
Patients infected with filoviruses and arenaviruses can be managed successfully without causing occupation-related symptomatic or asymptomatic infections. Meticulous attention to infection control and clinical biosafety practices by highly motivated, trained staff is critical to the safe care of patients with an infection from a special pathogen.
Quantitative Fe content determination of powders by Mössbauer spectroscopy is described. In this method, powder samples and internal standard are combined homogeneously in a plastic film ensuring a thin absorber. This method was verified by quantifying the Fe content of a series of samples and independently confirming by inductively coupled plasma optical emission spectroscopic analysis. Additionally, for the first time, Fe contamination in ball-milled Si as a function of milling time was quantified. It was found that Fe contamination increased with time but surprisingly became steady state at 1.12 ± 0.04 at.% Fe after grain size reduction.
Disturbed sleep and activity are prominent features of bipolar disorder type I (BP-I). However, the relationship of sleep and activity characteristics to brain structure and behavior in euthymic BP-I patients and their non-BP-I relatives is unknown. Additionally, underlying genetic relationships between these traits have not been investigated.
Relationships between sleep and activity phenotypes, assessed using actigraphy, with structural neuroimaging (brain) and cognitive and temperament (behavior) phenotypes were investigated in 558 euthymic individuals from multi-generational pedigrees including at least one member with BP-I. Genetic correlations between actigraphy-brain and actigraphy-behavior associations were assessed, and bivariate linkage analysis was conducted for trait pairs with evidence of shared genetic influences.
More physical activity and longer awake time were significantly associated with increased brain volumes and cortical thickness, better performance on neurocognitive measures of long-term memory and executive function, and less extreme scores on measures of temperament (impulsivity, cyclothymia). These associations did not differ between BP-I patients and their non-BP-I relatives. For nine activity-brain or activity-behavior pairs there was evidence for shared genetic influence (genetic correlations); of these pairs, a suggestive bivariate quantitative trait locus on chromosome 7 for wake duration and verbal working memory was identified.
Our findings indicate that increased physical activity and more adequate sleep are associated with increased brain size, better cognitive function and more stable temperament in BP-I patients and their non-BP-I relatives. Additionally, we found evidence for pleiotropy of several actigraphy-behavior and actigraphy-brain phenotypes, suggesting a shared genetic basis for these traits.
The chapter begins with a survey of musical comedy of the 1890s and early twentieth century. A brief account of Edward German and his operettas follows. Noël Coward established himself as a British operetta composer with Bitter Sweet in 1929. However, the person who did most to keep English operetta alive in the 1930s was the Welsh composer Ivor Novello (1893–1951). He gained a considerable amount of experience both as a composer for the stage and as an actor before completing his first operetta, Glamorous Night, in 1935. This chapter assesses Novello’s achievements, musical and dramatic, and investigates the critical reception of his operettas. It places him in the context of what came before (Fraser-Simson, Montague Phillips, Noël Coward) and what came after (Vivian Ellis, Julian Slade, Sandy Wilson).
It was exciting, no doubt, to watch silent films to the accompaniment of musical excerpts played by cinema orchestras, but the 1930s gave audiences the chance to see stars sing and act. That decade consequently offers valuable historical insight into vocal practice and performance technique. This chapter begins with an overview of freshly created screen operettas and of films adapting stage operettas. It briefly examines Die Drei von der Tankstelle (1930) and other German films, before moving to British and American films. The demands of film are contrasted with techniques required in the theatre. The chapter then looks at the practice of adaptation in Hollywood, and it ends with a discussion of the operetta Heimat film in Germany.
This introduction serves as an overview of the development of operetta and points to the neglect of operetta by many scholars of music and theatre. The editors begin by defining this genre, which is multi-faceted and often difficult to categorize. The introduction sets the stage for the following chapters by guiding the reader towards the important landmarks in the historical developments of operetta, such as those that occurred in France, Austria and London, and, in the twentieth century, in Berlin. In doing so, it also comments on notable composers and works. It concludes with some reflections on operetta reception in the twenty-first century.