The extent to which observed differences in emotion processing and
regulation neural circuitry in adolescents with a history of suicide attempt
are paralleled by structural differences is unknown. We measured brain
cortical thickness and grey- and white-matter volumes in 100 adolescents: 28
with a history of suicide attempt and major depressive disorder (MDD); 31
with a history of MDD but no suicide attempt; and a healthy control group
(n = 41). The first group compared with controls showed
reduction in grey-matter volume in the right superior temporal gyrus (BA38),
a region important for social emotion processing.