Available research supports the therapeutic usefulness of cognitive therapy for depressed older adults. Few studies have addressed the issue of response prediction. This research investigates the associations between several pre-intervention characteristics of subjects and therapy outcomes in the context of a group intervention. The characteristics under study were severity of depressive symptommatology, endogenous depression profile, subjective health status, perceived social support, and frequency of cognitive depressive symptoms representing a negative view of oneself. A more severe depressive symptomatology and a more negative health perception were associated with a less favourable outcome of therapy. Although the majority of endogenous patients benefitted from the intervention, only a minority reached the level of symptom remission at the end of treatment. A more pronounced cluster of symptoms characterized by negative thoughts about oneself tended to be associated with a worse outcome. Perceived social support was unrelated to therapy outcome.