Historically, the costs of work-related injury have been reported in macro-economic terms. Macro-economic cost alone, however, does not accurately portray the totality of costs that are incurred as a result of a work-related injury. This paper reviews the literature in the area of workplace injury cost estimation and highlights the complexities involved in the area. Using a case study analysis of six workplace injuries, this paper reports on the overall cost of work-related injury, and identifies the key determinants of cost. The research indicates that the actual costs of workplace injury can vary significantly to the “typical” costs as used in some macro-economic studies.