Field studies were conducted from 2009 through 2011 at the Sustainable Agriculture Research and Extension Center near Lingle, Wyoming, to evaluate great northern bean response to PRE flumioxazin mixed with either trifluralin, pendimethalin, or ethalfluralin. Seven treatments were arranged in a randomized complete block with three or four replicates y−1. The soil texture of the study site was loam in 2009 and 2011, and sandy loam in 2010. Soil organic matter ranged from 1.4% to 1.8%. Treatments included flumioxazin plus trifluralin, flumioxazin plus pendimethalin, flumioxazin plus ethalfluralin, ethalfluralin plus EPTC, imazamox plus bentazon (POST), hand-weeded control, and nontreated control. Dry bean density 4 wk after planting differed among herbicide treatments (P < 0.001). Treatments that included flumioxazin reduced dry bean density 54% compared with treatments without flumioxazin. Dry bean yield was influenced by dry bean density; on average, yield in flumioxazin-containing herbicide treatments was 30% less than treatments not containing flumioxazin, even though weed control was generally greater in flumioxazin treatments.