A large diversity of alien plants is found in most mediterranean-type climate (MTC) regions and fire is sometimes closely linked to their ability to invade natural ecosystems. This is a concern because aliens often upset natural ecosystem processes, and thus are a major management concern. These five regions not only differ in their contributions of non-native plant species to other regions, but also vary in their susceptibility to invasion by alien species, something often referred to as a community's invasibility.

Fire is a key factor behind plant invasions into natural plant communities and particularly critical is the timing of propagule availability and characteristics of the fire regime. Fire also interacts with geology in dictating functional types that become pernicious invasive problems. For example, on coarse-textured low-fertility soils in two of the southern hemisphere MTC regions, shrubs and trees are among the most aggressive invasives, and are capable of invading seemingly undisturbed intact shrublands. However, on more fertile soils such as in California and Chile, grasses and other herbaceous species are bigger threats, but invasion typically requires disturbance and under some circumstances fire can effect type conversion from woody vegetation to alien-dominated grasslands.