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25 - The Drosophila eye and the genetics of schizophrenia

Published online by Cambridge University Press:  04 May 2010

Steven Matthysse
Affiliation:
Harvard University, Massachusetts
Francine M. Benes
Affiliation:
McClean Hospital
Deborah L. Levy
Affiliation:
Harvard University, Massachusetts
Jerome Kagan
Affiliation:
Harvard University, Massachusetts
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Summary

Cognitive processing defects in schizophrenia

I would like to indulge in a little pole-vaulting across phyla, from Drosophila to schizophrenia. This familiar academic sport is usually played by the sellers of animal models, rather than the buyers; but as I work on schizophrenia and not on Drosophila, one unique feature of this exercise is that it will be from a buyer's point of view.

It seems to me (and many others) that schizophrenia is best understood as a failure of some aspects of what cognitive psychologists call automatic processing: the background of cognitive activity, carried out without awareness, that supports and facilitates conscious, effortful thought [32]. The existence of efficient cognitive preprocessing mechanisms is suggested by the ease and naturalness of thinking in normal people, despite the complex requirements thinking must meet to function competently. Our thought is able to navigate between Holzman's 20 categories of thought disorder [15, pp. 69-70]. Our memory can take advantage of context and predictability of word sequences, as Brendan Maher has observed (Chapter 19, this volume). Our language must conform to rules of syntax, semantics, logic and pragmatics. Nevertheless, ordinary thinking and speaking demand no special concentration and take hardly any time. We do not calculate before we speak, nor do we form our thoughts by a process of trial and error; we do not have to sift through a mixture of logical and illogical, grammatical and ungrammatical thoughts.

Type
Chapter
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Psychopathology
The Evolving Science of Mental Disorder
, pp. 557 - 580
Publisher: Cambridge University Press
Print publication year: 1996

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