Book contents
- Frontmatter
- Contents
- List of Figures
- List of Tables
- Preface
- 1 The Vitamins
- 2 Vitamin A: Retinoids and Carotenoids
- 3 Vitamin D
- 4 Vitamin E: Tocopherols and Tocotrienols
- 5 Vitamin K
- 6 Vitamin B1 – Thiamin
- 7 Vitamin B2 – Riboflavin
- 8 Niacin
- 9 Vitamin B6
- 10 Folate and Other Pterins and Vitamin B12
- 11 Biotin (Vitamin H)
- 12 Pantothenic Acid
- 13 Vitamin C (Ascorbic Acid)
- 14 Marginal Compounds and Phytonutrients
- Bibliography
- Index
8 - Niacin
Published online by Cambridge University Press: 03 December 2009
- Frontmatter
- Contents
- List of Figures
- List of Tables
- Preface
- 1 The Vitamins
- 2 Vitamin A: Retinoids and Carotenoids
- 3 Vitamin D
- 4 Vitamin E: Tocopherols and Tocotrienols
- 5 Vitamin K
- 6 Vitamin B1 – Thiamin
- 7 Vitamin B2 – Riboflavin
- 8 Niacin
- 9 Vitamin B6
- 10 Folate and Other Pterins and Vitamin B12
- 11 Biotin (Vitamin H)
- 12 Pantothenic Acid
- 13 Vitamin C (Ascorbic Acid)
- 14 Marginal Compounds and Phytonutrients
- Bibliography
- Index
Summary
Niacin is unusual among the vitamins in that it was discovered as a chemical compound, nicotinic acid produced by the oxidation of nicotine, in 1867 – long before there was any suspicion that it might have a role in nutrition. Its metabolic function as part of what was then called coenzyme II [nicotinamide adenine dinucleotide phosphate (NADP)] was discovered in 1935, again before its nutritional significance was known.
It is not strictly correct to regard niacin as a vitamin. Its metabolic role is as the precursor of the nicotinamide moiety of the nicotinamide nucleotide coenzymes, nicotinamide adenine dinucleotide (NAD) and NADP, and this can also be synthesized in vivo from the essential amino acid tryptophan. At least in developed countries, average intakes of protein provide more than enough tryptophan to meet requirements for NAD synthesis without any need for preformed niacin. It is only when tryptophan metabolism is disturbed, or intake of the amino acid is inadequate, that niacin becomes a dietary essential.
The nicotinamide nucleotide coenzymes function as electron carriers in a wide variety of redox reactions. In addition, NAD is the precursor of adenine dinucleotide phosphate (ADP)-ribose for ADP-ribosylation and poly(ADP-ribosylation) of proteins and cADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP). They act as second messengers and stimulate increases in intracellular calcium concentrations.
Pellagra was first described as mal de la rosa in Asturias in central Spain by Casal in 1735. He observed that the condition was apparently related to diet and was distinct fromscurvy and other then knowncauses of superficially similar dermatitis.
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- Nutritional Biochemistry of the Vitamins , pp. 200 - 231Publisher: Cambridge University PressPrint publication year: 2003
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