Book contents
- Frontmatter
- Contents
- Contributors
- Foreword
- Acknowledgements
- Biographical note on F. H. Lewy
- Abbreviations
- Group photograph
- Introduction
- Part one Clinical issues
- Part two Pathological issues
- 15 Pathological significance of Lewy bodies in dementia
- 16 Tautological tangles in neuropathologic criteria for dementias associated with Lewy bodies
- 17 What is the neuropathological basis of dementia associated with Lewy bodies?
- 18 Cytoskeletal and Alzheimer-type pathology in Lewy body disease
- 19 Diffuse Lewy body disease within the spectrum of Lewy body disease
- 20 Temporal lobe immunohistochemical pathology for tangles, plaques and Lewy bodies in diffuse Lewy body disease, Parkinson's disease, and senile dementia of Alzheimer type
- 21 Pathological and clinical features of Parkinson's disease with and without dementia
- 22 Dementia with Lewy bodies: relationships to Parkinson's and Alzheimer's diseases
- 23 What do Lewy bodies tell us about dementia and parkinsonism?
- 24 Pathogenesis of the Lewy body
- 25 Altered tau processing: its role in development of dementia in Alzheimer's disease and Lewy body disease
- 26 Cytoskeletal pathology in Alzheimer's disease and Lewy body dementia – an epiphenomenon?
- 27 Genetic correlations in Lewy body disease
- Résumeacute; of pathological workshop sessions
- Part three Treatment issues
- Appendices
- Index
- Plate section
21 - Pathological and clinical features of Parkinson's disease with and without dementia
from Part two - Pathological issues
Published online by Cambridge University Press: 06 July 2010
- Frontmatter
- Contents
- Contributors
- Foreword
- Acknowledgements
- Biographical note on F. H. Lewy
- Abbreviations
- Group photograph
- Introduction
- Part one Clinical issues
- Part two Pathological issues
- 15 Pathological significance of Lewy bodies in dementia
- 16 Tautological tangles in neuropathologic criteria for dementias associated with Lewy bodies
- 17 What is the neuropathological basis of dementia associated with Lewy bodies?
- 18 Cytoskeletal and Alzheimer-type pathology in Lewy body disease
- 19 Diffuse Lewy body disease within the spectrum of Lewy body disease
- 20 Temporal lobe immunohistochemical pathology for tangles, plaques and Lewy bodies in diffuse Lewy body disease, Parkinson's disease, and senile dementia of Alzheimer type
- 21 Pathological and clinical features of Parkinson's disease with and without dementia
- 22 Dementia with Lewy bodies: relationships to Parkinson's and Alzheimer's diseases
- 23 What do Lewy bodies tell us about dementia and parkinsonism?
- 24 Pathogenesis of the Lewy body
- 25 Altered tau processing: its role in development of dementia in Alzheimer's disease and Lewy body disease
- 26 Cytoskeletal pathology in Alzheimer's disease and Lewy body dementia – an epiphenomenon?
- 27 Genetic correlations in Lewy body disease
- Résumeacute; of pathological workshop sessions
- Part three Treatment issues
- Appendices
- Index
- Plate section
Summary
Summary
The pathology of Parkinson's disease (PD) is characterized by the presence of neuronal loss, Lewy bodies (LBs), and Lewy neurites (LNs) at predilection sites in the nervous system. During the course of PD a characteristic pattern of lesions develops in both the central and peripheral nervous system, with a predominant involvement of ‘efferent’ subcortical structures such as the substantia nigra and amygdala. ‘Afferent’ cortical structures such as the entorhinal region are frequently involved in Alzheimer-type pathology. In this chapter the clinical features and postmortem findings of 33 patients with PD are reviewed and compared, with special attention being paid to the frequent but not exclusive association of LBs/LNs with Alzheimer-type pathology. Although a clear relationship between the neuropathological findings and the clinical features of psychopathology and/or dementia could not be observed, one could speculate that the Parkinson-specific lesions in cortical and subcortical structures and the Alzheimer-type pathology, which is seen most often in the entorhinal region, reinforce each other and thus are responsible for the development of dementia in PD. CA2 ubiquitin-immunoreactive neurites were found in almost all patients with PD and should be considered a normal finding in PD, irrespective of whether or not the patient is demented.
Introduction
Thirty-three patients with a clinical history of Parkinson's disease (PD), with or without concomitant affective, behavioral, and/or cognitive changes were assessed. They were referred to the Department of Neurology of the Medisch Spectrum Twente, The Netherlands, to determine the relationship, if any, between clinical PD with or without dementia and neuropathological changes.
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- Information
- Dementia with Lewy BodiesClinical, Pathological, and Treatment Issues, pp. 255 - 267Publisher: Cambridge University PressPrint publication year: 1996
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