Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-hfldf Total loading time: 0 Render date: 2024-06-03T02:27:35.555Z Has data issue: false hasContentIssue false

34 - Mood disorders

from Part III - Behavior problems

Published online by Cambridge University Press:  26 October 2009

Get access

Summary

Hippocrates felt that melancholiacs become epileptics and epileptics become melancholic. What is spoken of now as mood disorders of epilepsy was once envisioned as an epileptic personality described as languid, spiritless, unsociable in any period of life, sleepless, and subject to many horrid dreams (Kanner & Balabanov, 2002).

Mood disorders include major depression, bipolar disorder, dysthymic disorders, and a double depression state. Major depression usually begins in late adolescence but has been diagnosed as early as four years of age. A bipolar disorder may vary as to the age of appearance. In children and younger teens, both mania and deep depression may present simultaneously, whereas in older adolescents, the more typical cycle between mania and deep depression is noted. A dysthymic disorder is a chronic, persistent, mild depression that begins in early childhood and lasts for decades. A double depression is seen in individuals who alternate between a dysthymic disorder and a major depression.

In epilepsy, there are three types of mood disorder, ictal, peri-ictal, and interictal. Peri-ictal disorders include the cluster of affective systems that may precede or follow a seizure by hours to days. Ictal disorders represent seizures presenting with affective symptoms. There is an interictal dysphoric disorder with an intermittent course, including depressive mood, lack of energy, pain, and insomnia. The affective symptoms include irritability, euphoria, fear, and anxiety (Barry et al., 2001).

Depression

Depression is often unrecognized and undertreated in patients with epilepsy, especially children.

Type
Chapter
Information
Childhood Epilepsy
Language, Learning and Behavioural Complications
, pp. 508 - 532
Publisher: Cambridge University Press
Print publication year: 2004

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Altshuler, L. L., Devinsky, O., Post, R. M., et al. (1990). Depression, anxiety, and temporal lobe epilepsy. Laterality of focus and symptoms. Arch. Neurol. 47: 284–8CrossRefGoogle Scholar
Barabas, G. & Matthews, W. (1988). Barbiturate anticonvulsants as a cause of severe depression. Pediatrics 82: 284–5Google ScholarPubMed
Barraclough, B. (1981). Suicide and epilepsy. In Epilepsy and Psychiatry, ed. F. H. Reynolds & M. R. Trimble, pp. 72–6. Edinburgh: Churchill Livingstone
Barry, J., Lembke, A. & Huynh, N. (2001). Affective disorders in epilepsy. In Psychiatric Issues in Epilepsy, ed. A. B. Ettinger & A. M. Kanner, pp. 45–72. Philadelphia: Lippincott Williams & Wilkins
Becu, M., Becti, N., Manzur, G., et al. (1993). Self-help epilepsy groups: an evaluation of effect on depression and schizophrenia. Epilepsia 34: 841–55CrossRefGoogle Scholar
Betts, T. A. (1981). Depression, anxiety and epilepsy. In Epilepsy and Psychiatry, ed. E. H. Reynolds & M. R. Trimble, pp. 60–71. Edinburgh: Churchill Livingstone
Blanchet, P. & Frommer, G. P. (1986). Mood change preceding epileptic seizures. J. Nerv. Ment. Dis. 174: 471–6CrossRefGoogle ScholarPubMed
Blumer, D. (1991). Epilepsy and disorders of mood. In Neurobehavioral Problems in Epilepsy, ed. D. B. Smith, D. M. Treiman & M. R. Trimble, pp. 185–95. New York: Raven Press
Blumer, D. (1992). Postictal depression: significance for the neurobehavioral disorder of epilepsy. J. Epilepsy 5: 214–19CrossRefGoogle Scholar
Blumer, D. & Zielinski, J. (1988). Pharmacologic treatment or psychiatric disorders associated with epilepsy. J. Epilepsy 1: 135–50CrossRefGoogle Scholar
Brent, D. A., Crumrine, P. K., Varma, R. R., et al. (1987). Phenobarbital treatment and major depressive disorder in children with epilepsy. Pediatrics 80: 909–17Google ScholarPubMed
Bromfield, E. B., Altshuler, L. & Leidermann, D. B. (1990). Cerebral metabolism and depression in patients with complex partial seizures. Epilepsia 31: 625Google Scholar
Calabrese, J. R., Fatemi, S. H. & Woyshville, M. J. (1996). Antidepressant effects of lamotrigine in rapid cycling bipolar disorder. Am. J. Psychiatry 153: 1236Google ScholarPubMed
Carlson, G. A. & Abbott, S. F. (1995). Mood disorders and suicide. In Comprehensive Textbook of Psychiatry, ed. H. I. Kaplan & B. J. Sadock, pp. 2367–91. Baltimore, MD: Williams & Wilkins
Currie, S., Heathfield, K. & Henson, R. (1971). Clinical course and prognosis of temporal lobe epilepsy: a survey of 666 patients. Brain 94: 173–90CrossRefGoogle ScholarPubMed
Davies, R. E. (1979). Manic depressive variant syndrome of childhood: a preliminary report. Am. J. Psychiatry 136: 702–6Google Scholar
Deb, S. & Hunter, D. (1991). Psychopathology of people with mental handicap and epilepsy. II: psychiatric illness. Br. J. Psychiatry 159: 826–30CrossRefGoogle ScholarPubMed
Devinsky, O., Kelley, K., Yacubian, E. M. T., et al. (1994). Postictal behavior: a clinical and subdural electroencephalographic study. Arch. Neurol. 51: 254–9CrossRefGoogle ScholarPubMed
Dodrill, C. B., Breyer, D. N., Diamond, M. B., et al. (1984). Psychosocial problems among adults with epilepsy. Epilepsia 25: 168–75CrossRefGoogle ScholarPubMed
Dunn, D. W. (1996). Factors related to depression in adolescents with epilepsy. Presented at the American Epilepsy Society Conference, 1996
Dunn, D. W., Austin, J. K. & Huyster, G. A. (1997). Behavior problems in children with new-onset epilepsy. Seizure 6: 283–7CrossRefGoogle ScholarPubMed
Emrich, M., Dose, M. & Zerssen, D. (1985). The use of sodium valproate, carbamazepine and oxcarbazepine in patients with affective disorders. J. Affect. Disord. 8: 243–50CrossRefGoogle ScholarPubMed
Ettinger, A. B. & Perrine, K. (1996). Psychiatric/psychosocial issues in epilepsy. In Epilepsy Update, ed. J. French, W. D. Shields, T. T. Sutula & B. W. Braxton, pp. 13–24. Norwalk, CT: GEM Communications
Faedda, G., Baldessarini, R., Suppes, T., et al. (1995). Pediatric-onset bipolar disorder: a neglected clinical and public health problem. Harv. Rev. Psychiatry 3: 171–95CrossRefGoogle ScholarPubMed
Farone, S. V., Biederman, J., Mennin, D., et al. (1997). Attention deficit hyperactivity disorder with bipolar disorder: a familial subtype?J. Am. Acad. Child Adolesc. Psychiatry 36: 1378–87, 1387–90CrossRefGoogle Scholar
Favale, E., Rubino, V., Mainardi, P., et al. (1995). The anticonvulsant effect of fluoxetine in humans. Neurology 45: 1925–7CrossRefGoogle ScholarPubMed
Fenwick, P. B. C. (1992). Antiepileptic drugs and their psychotropic effects. Epilepsia 33 (suppl 6): 533–6Google ScholarPubMed
Fiordelli, E., Beghi, E., Bogliun, G., et al. (1993). Epilepsy and pscyhaitric disutrbance. A cross-sectional study. Br. J. Psychiatry 163: 446–50CrossRefGoogle ScholarPubMed
Frangos, E. & Alexandrakou, P. (1991). Temporal lobe epilepsy and affective disorders. 19th International Epilepsy Congress. Epilepsia 32 (suppl 1): 51Google Scholar
Gehlert, S. (1994). Perceptions of control in adults with epilepsy. Epilepsia 35: 81–8CrossRefGoogle ScholarPubMed
Geller, B. & Luby, J. (1997). Child and adolescent bipolar disorder: a review of the past 10 years. J. Am. Acad. Child Adolesc. Psychiatry 36: 1168–76CrossRefGoogle ScholarPubMed
Gillham, R. A. (1990). Refractory epilepsy: an evaluation of psychological methods in outpatient management. Epilepsia 31: 427–32CrossRefGoogle ScholarPubMed
Gilliam, F., Maton, B., Martin, R. C., et al. (2000). Extent of 1H spectroscopic abnormalities independently predicts mood status and quality of life in temporal lobe epilepsy. Epilepsia 41 (suppl 7): 54Google Scholar
Glauser, T. A. (1999). Topiramate. Epilepsia 40 (suppl 5): 71–80CrossRefGoogle ScholarPubMed
Harden, C. L. (2002). The co-morbidity of depression and epilepsy, epidemiology, etiology and treatment, Neurology 59 (suppl 4): 48–55CrossRefGoogle Scholar
Harris, E. C. & Barraclough, B. (1997). Suicide as an outcome for mental disorders: a meta-analysis. Br. J. Psychiatry 170: 205–28CrossRefGoogle ScholarPubMed
Hauser, W. A. & Hesdorffer, D. C. (2000). Psychosis, depression and epilepsy: epidemiologic considerations. In Psychiatric Issues in Epilepsy: A Practical Guide to Diagnosis and Treatment, ed. A. B. Ettinger & A. M. Kanno, pp. 7–17. Philadelphia: Lippincott Williams & Wilkins
Hawton, K., Fagg, J. & Marsack, P. (1980). Association between epilepsy and attempted suicide. J. Neurol. Neuosurg. Psychiatry 43: 168–70CrossRefGoogle ScholarPubMed
Heilman, K. M., Scholes, R. & Watson, R. T. (1975). Auditory affective agnosia: disturbed comprehension of affective speech. J. Neurol. Neurosurg. Psychiatry 38: 69–71CrossRefGoogle ScholarPubMed
Hermann, B. P. & Whitman, S. (1989). Psychosocial predictors of interictal depression. J. Epilepsy 2: 231–7CrossRefGoogle Scholar
Hermann, B. P. & Wyler, A. R. (1989). Depression, locus of control, and the effects of epilepsy surgery. Epilepsia 30: 332–8CrossRefGoogle ScholarPubMed
Hermann, B. P., Seidenberg, M. & Bell, B. (2000). Psychiatric comorbidity in chronic epilepsy: identification, consequences, and treatment of major depression. Epilepsia 41 (suppl 2): 31–41CrossRefGoogle ScholarPubMed
Indaco, A., Carrieri, P. B., Nappi, C., et al. (1992). Interictal depression in epilepsy. Epilepsy Res. 12: 45–50CrossRefGoogle ScholarPubMed
Jacoby, A. (1992). Epilepsy and the quality of everyday life: findings from a study of people with well-controlled epilepsy. Soc. Sci. Med. 42: 657–66CrossRefGoogle Scholar
Kanner, A. M. & Balabanov, A. (2002). Depression and epilepsy: how closely related are they?Neurology 58 (suppl 5): 27–39CrossRefGoogle Scholar
Kashani, J. H., Carson, G. A., Beck, N. C., et al. (1987). Depression, depressive symptoms and depressed mood among a community sample of adolescentsAm. J. Psych. 144: 931–4Google ScholarPubMed
Keller, M. B., Lavori, P. W., Klerman, G. L., et al. (1986). Low levels and lack of predictors of somatotherapy and psychotherapy received by depressed patients. Arch. Gen. Psychiatry 43: 458–68CrossRefGoogle ScholarPubMed
Kendrick, A. M., Duncan, J. S. & Trimble, M. R. (1993). Effects of discontinuation of individual antiepileptic drugs on mood. Hum. Psychopharmacol. 8: 263–70CrossRefGoogle Scholar
Klerman, G. L. (1990). Treatment of recurrent unipolar major depressive disorder: commentary on the Pittsburgh Study. Arch. Gen. Psychiatry 47: 1158–61CrossRefGoogle ScholarPubMed
Koch-Weser, M., Garron, D. C., Gilley, D. W., et al. (1988). Prevalence of psychological disorders after surgical treatment of seizuresArch. Neurol. 45: 1308–11CrossRefGoogle ScholarPubMed
Kogeorgos, J., Fonagy, P. & Scott, D. F. (1982). Psychiatric symptom patterns of chronic epileptics attending a neurological clinic: a controlled investigation. Br. J. Psychiatry 140: 236–43CrossRefGoogle ScholarPubMed
Kudo, T., Ishida, S., Kubota, H., et al. (2001). Manic episode in epilepsy and bipolar disorder: a comparative analysis of 13 patients. Epilespia 42: 1036–42CrossRefGoogle ScholarPubMed
Kupfer, D. J., Frank, E. & Perel, J. M. (1989). The advantage of early treatment intervention in recurrent depression. Arch. Gen. Psychiatry 46: 771–5Google ScholarPubMed
Lambert, M. V. & Robertson, M. M. (1999). Depression in epilepsy: etiology, phenomenology and treatment. Epilepsia 40 (suppl 10): 21–47CrossRefGoogle ScholarPubMed
Long, C. G. & Moore, J. R. (1979). Parental expectations for their epileptic children. J. Child Psychol. Psychiatry 20: 299–312CrossRefGoogle ScholarPubMed
Lopez-Rodriguez, F., Altshuler, L. & Kay, J. (1999). Depression and laterality of epileptogenic region in patients with medically-refractory temporal lobe epilepsy. Epilepsia 40 (suppl 7): 60Google Scholar
Lyketsos, C. G., Stoline, A. M., Longstreet, P., et al. (1993). Mania in temporal lobe epilepsy. Neuropsychiatry Neuropsychol. Behav. Neurol. 6: 19–25Google Scholar
Macniak, J. (1999). Studies on depression disorders in temporal lobe epilepsy in adolescents. 23rd International Epilepsy Congress. Epilepsia 40 (suppl 2): 274Google Scholar
Mayou, R. & Hawton, K. (1986). Psychiatric disorder in the general hospital. Br. J. Psychiatry 149: 172–90CrossRefGoogle ScholarPubMed
Meldrum, B. S. (1991). Neurochemical substrates of ictal behavior. In Neurobehavioral problems in epilepsy, ed. D. B. Smith & D. M. Treiman, Vol. 55, pp. 35–45. New York: Raven Press
Mendez, M. F., Cummings, J. L. & Benson, D. F. (1986). Depression in epilepsy: significance and phenomenology. Arch. Neurol. 43: 766–70CrossRefGoogle ScholarPubMed
Mendez, M. F., Doss, R. C., Taylor, J. L., et al. (1993). Depression in epilepsy: relationship to seizures and anticonvulsant therapy. J. Nen. Ment. Dis. 181: 444–7CrossRefGoogle ScholarPubMed
Mittan, R. (1986). Fear of seizures. In Psychopathology in Epilepsy: Social Dimensions, ed. S. Whitman & B. P. Hermann, pp. 90–121. New York: Oxford University Press
Mittan, R. (1987). The influence of seizure–related variables upon patients' fears of death and brain damage. Epilepsia 28: 540Google Scholar
Murray, R. E., Abou-Khalil, B. & Griner, L. (1994). Evidence for familial association of psychiatric disorders and epilepsy. Biol. Psychiatry 36: 428–9CrossRef
Onuma, T. (2000). Classification of psychiatric symptoms in patients with epilepsy. Proceedings of the 32nd Congress of Japan Epilepsy Society. Epilepsia 41 (suppl 9): 43–8CrossRefGoogle Scholar
Piazza, A. & Canger, R. (2001). Depression and anxiety in patients with epilepsy. In Epilespia and Learning Disabilities, ed. G. F. Ayala, M. Elia, C. M. Cornaggia & M. R. Trimble. Epilepsia 42: 29–31
Pisani, F., Spina, E. & Oteri, G. (1999). Antidepressant drugs and seizure susceptibility: from in vitro data to clinical practice. Epilepsia 30 (suppl 10): 38–56Google Scholar
Pratt, J. A., Jenner, P., Johnson, A. L., et al. (1984). Anticonvulsant drugs alter plasma tryptophan concentrations in epileptic patients: implications for antiepileptic action and mental function. J. Neurol. Neurosurg. Psychiatry 47: 1131–3CrossRefGoogle ScholarPubMed
Prediville, S. & Gale, K. (1993). Anticonvulsant effect of fluoxetine on focally evoked limbic motor seizures in rats. Epilepsia 34: 381–4CrossRefGoogle Scholar
Prien, R. F. & Kupfer, D. J. (1986). Continuation drug therapy for major depressive episodes: how long should it be maintained?Am. J. Psychiatry 143: 18–23Google ScholarPubMed
Ratti, M. T., Raffacle, M., Galimberti, C. A., et al. (1998). Depressed mood in people with epilepsy. 3rd European Congress of Epilepsy. Epilepsia 39 (suppl): 122Google Scholar
Rey, G., Carrazana, E., Garaycoa, G., et. al. (2000). Affective disorders in juvenile myoclonic epielspy: a prospective study. Epilepsia 41 (suppl 7): 236Google Scholar
Ring, H. A., Moriarty, J. & Trimble, M. R. (1998). A prospective study of the early postsurgical psychiatric associations of epilepsy surgery. J. Neurol. Neurosurg. Psychiatry 64: 601–4CrossRefGoogle ScholarPubMed
Roberts, A. (1995). The use of antidepressant drugs in general practice. Prescriber 5: 35–53Google Scholar
Robertson, M. M. (1997). Depression in neurological disorders. In Depression and Physical Illness, ed. M. M. Robertson & C. L. E. Katona, pp. 305–40. Chichester, UK: John Wiley & Sons
Robertson, M. M. (1998). Mood disorders associated with epilepsy. In Psychiatric Comorbidity in Epilepsy. Basic Mechanisms, Diagnosis, and Treatment, ed. H. W. McConnell & P. J. Sander, pp. 132–67. Washington, DC: American Psychiatric Press
Ronald, S. & Duman, R. (1999). The neurochemistry of mood disorders: preclinical studies. In Neurobiology of Mental Illness, ed. D. S. Charney, E. J. Nesler & B. S. Bunney, pp. 333–48. New York: Oxford University Press
Ryback, R. S., Brodsky, L. & Munasilfi, F. (1997). Gabapentin in bipolar disorder. J. Neuropsych. Clin. Neurosci. 9: 301CrossRefGoogle ScholarPubMed
Sarzhevskiy, S. (1998). Peculiarities of depression owing to drug treatment in epilepsy. 3rd European Congress of Epileptology. Epilepsia 39 (suppl 2): 123Google Scholar
Schaffer, C. B. & Schaffer, L. C. (1997). Gabapentin in the treatment of bipolar disorder. Am. J. Psychiatry 154: 291–2Google ScholarPubMed
Schou, M., Amdisen, A. & Trap-Jensen, J. (1979). Lithium poisoning. Am. J. Psychiatry 125: 520–27CrossRefGoogle Scholar
Shukla, S., Mukherjee, S. & Decina, P. (1988). Lithium in the treatment of bipolar disorders associated with epilepsy: an open study. J. Clin. Psychopharmacol. 8: 201–4CrossRefGoogle Scholar
Simard, M., Gumbiner, B., Lee, A., et al. (1989). Lithium carbonate intoxication: a case report and review of the literature. Arch. Intern. Med. 194: 36–46CrossRefGoogle Scholar
Smith, D. B. & Collins, J. B. (1987). Behavioral effects of carbamazepine, phenobarbital, phenytoin and primidone. Epilepsia 28: 598Google ScholarPubMed
Sporn, J. & Sachs, G. (1997). The anticonvulsant lamotrigine in treatment resistant manic-depressive illness. J. Clin. Psychopharmacol. 17: 185–9CrossRefGoogle ScholarPubMed
Spring, G. K. (1980). EEG observations in confirming neurotoxicity. Am. J. Psychiatry 136: 1099–100Google Scholar
Standage, K. F. & Fenton, G. W. (1975). Psychiatric symptom profiles of patients with epilepsy: a controlled investigation. Psychol. Med. 5: 152–60CrossRefGoogle ScholarPubMed
Strauss, E, Wada, J. & Moll, A. (1992). Depression in male and female subjects with complex partial seizures. Arch. Neurol. 49: 391–2CrossRefGoogle ScholarPubMed
Taylor, D. C. (1972). Mental state and temporal lobe epilepsy: a correlative account of 100 patients treated surgically. Epilepsia 13: 727–65CrossRefGoogle ScholarPubMed
Thompson, P. J. (1991). Memory function in patients with epilepsy. In Neurobehavioral Problems in Epilepsy. Advances in Neurology, ed. D. Smith, D. Treiman & M. R. Trimble, Vol. 55, pp. 369–84. New York: Raven Press
Trimble, M. R. (1988). Biological Psychiatry. New York: John Wiley & Sons
Usiskin, S. (1995). Counseling in epilepsy. In Epilepsy, 2nd edn, ed. A. Hopkins, S. Shorvon & G. Cascino, pp. 565–71. London: Chapman & Hall
Vickrey, B. G., Hays, R. D., Graber, J., et al. (1992). A health-related quality of life instrument for patients evaluated for epilepsy surgery. Med. Care 30: 299–319CrossRefGoogle ScholarPubMed
Viikinsalo, M., Sawrie, S., Kuzniecky, R., et al. (2000). Depression and medication toxicity but not seizure frequency of severity predict health outcomes in refractory epilepsy. Epilepsia 41 (suppl 7): 174Google Scholar
Walden, J., Hesslinger, B., van-Calker, D., et al. (1996). Addition of lamotrigine to valproate may enhance efficacy in the treatment of bipolar affective disorder. Pharmacopsychiatry 29: 193–5CrossRefGoogle ScholarPubMed
Weil, A. A. (1959). Ictal emotions occurring in temporal lobe dysfunction. Arch. Neurol. 1: 87–97CrossRefGoogle ScholarPubMed
Weisbrot, D. M. & Ettinger, A. B. (1998). Psychiatric aspects of pediatric epilepsy. Primary PsychiatryJune: 51–67
Weller, E., Weller, R. & Fristad, M. (1995). Bipolar disorder in children: misdiagnosis, under diagnosis and future directions. J. Am. Acad. Child Adolesc. Psychiatry 34: 709–14CrossRefGoogle Scholar
Weller, R. A., Weller, E. B., Tucker, S. G., et al. (1986). Mania in prepubertal children: has it been underdiagnosed?J. Affect. Disord. 11: 151–4CrossRefGoogle ScholarPubMed
Wharton, R. N. (1969). Grand mal seizures with lithium treatment. Am. J. Psychiatry 125: 152CrossRefGoogle ScholarPubMed
Williams, D. (1956). The structure of emotions reflected in epileptic experiences. Brain 79: 29–67CrossRefGoogle ScholarPubMed
Wozniak, J., Biederman, J. & Richards, J. A. (2001). Diagnostic and therapeutic dilemmas in the management of pediatric-onset bipolar disorder. J. Clin. Psychiatry 62 (suppl 14): 10–15Google ScholarPubMed
Zielinski, J. J. (1974). Epilepsy and mortality rate and cause of death. Epilepsia 15: 191–201CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×