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Chapter 6 - The Gonadotropins in IVF

r-hFSH or u-hFSH, Biosimilars, Regimens, Doses: Which Protocol

from Section 2 - Stimulation for IVF

Published online by Cambridge University Press:  04 January 2019

Gabor Kovacs
Affiliation:
Monash University, Victoria
Anthony Rutherford
Affiliation:
University of Leeds
David K. Gardner
Affiliation:
University of Melbourne
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Publisher: Cambridge University Press
Print publication year: 2019

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References

Edwards, RG. The history of assisted human conception with especial reference to endocrinology. Exp Clin Endocrinol Diabetes. 1996;104:183204.Google Scholar
Steptoe, PC, Edwards, RG. Laparoscopic recovery of preovulatory human oocytes after priming of ovaries with gonadotrophins. Lancet. 1970; 1(7649):683–9.Google ScholarPubMed
Steptoe, PC, Edwards, RG. Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet. 1976;1(7965):880–2.Google ScholarPubMed
Edwards, RG, Steptoe, PC, Purdy, JM. Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br J Obstet Gynaecol. 1980;87:737–56.CrossRefGoogle ScholarPubMed
Jones, HW Jr, Jones, GS, Andrews, MC et al. The program for in vitro fertilization at Norfolk. Fertil Steril. 1982 Jul;38(1):1421.Google Scholar
Trounson, AO, Leeton, JF, Wood, C, Webb, J, Wood, J. Pregnancies in humans by fertilization in vitro and embryo transfer in the controlled ovulatory cycle. Science 1981;212:681–2.Google Scholar
Fishel, SB, Edwards, RG, Purdy, JM et al. Implantation, abortion, and birth after in vitro fertilization using the natural menstrual cycle or follicular stimulation with clomiphene citrate and human menopausal gonadotropin. J In Vitro Fert Embryo Transf. 1985;2:123–31.CrossRefGoogle ScholarPubMed
Lunenfeld, B. Historical perspectives in gonadotrophin therapy. Human Reproduction Update 2004;10:453–67.Google Scholar
Howles, CM. Recombinant gonadotrophins in reproductive medicine: the gold standard of today. Reprod Biomed Online. 2006;12:11–3.Google Scholar
Lispi, M, Bassett, R, Crisci, C et al. Comparative assessment of the consistency and quality of a highly purified FSH extracted from human urine (urofollitropin) and a recombinant human FSH (follitropin alpha). Reprod Biomed Online. 2006;13:179–93.Google Scholar
Boostanfar, R, Mannaerts, B, Pang, S et al. A comparison of live birth rates and cumulative ongoing pregnancy rates between Europe and North America after ovarian stimulation with corifollitropin alfa or recombinant follicle-stimulating hormone. Fertil Steril. 2012;97:1351–8.Google Scholar
Wide, L, Bakos, O. More basic forms of both human follicle-stimulating hormone and luteinizing hormone in serum at midcycle compared with the follicular or luteal phase. J Clin Endocrinol Metab. 1993;76:885–9.Google ScholarPubMed
Wide, L, Naessén, T, Sundström-Poromaa, I, Eriksson, K. Sulfonation and sialylation of gonadotropins in women during the menstrual cycle, after menopause, and with polycystic ovarian syndrome and in men. J Clin Endocrinol Metab. 2007;92:4410–7.Google Scholar
Wide, L, Naessén, T, Eriksson, K. Effects of 17beta-oestradiol and norethisterone acetate on sulfonation and sialylation of gonadotrophins in post-menopausal women. Ups J Med Sci. 2010;115:97106.Google Scholar
Horsman, G, Talbot, JA, McLoughlin, JD, Lambert, A, Robertson, WR. A biological, immunological and physico-chemical comparison of the current clinical batches of the recombinant FSH preparations Gonal-F and Puregon. Hum Reprod. 2000;15:1898–902.Google Scholar
Howles, CM. Genetic engineering of human FSH (Gonal-F). Hum Reprod Update. 1996;2:172–91.CrossRefGoogle ScholarPubMed
Loumaye, E, Martineau, I, Piazzi, A et al. Clinical assessment of human gonadotrophins produced by recombinant DNA technology. Hum Reprod. 1996;11 Suppl 1:95107.Google Scholar
Driebergen, R, Baer, G. Quantification of follicle stimulating hormone (follitropin alfa): is in vivo bioassay still relevant in the recombinant age? Curr Med Res Opin. 2003;19:41–6.CrossRefGoogle ScholarPubMed
Fauser, BC, Mannaerts, BM, Devroey, P et al. Advances in recombinant DNA technology: corifollitropin alfa, a hybrid molecule with sustained follicle-stimulating activity and reduced injection frequency. Hum Reprod Update. 2009;15:309–21.Google Scholar
Scholtes, MC, Schnittert, B, van Hoogstraten, D et al. A comparison of 3-day and daily follicle-stimulating hormone injections on stimulation days 1–6 in women undergoing controlled ovarian hyperstimulation. Fertil Steril. 2004; 81:9961001.Google Scholar
Orvieto, R, Seifer, DB. Biosimilar FSH preparations: are they identical twins or just siblings? Reprod Biol Endocrinol. 2016; 14:32.Google Scholar
Schiestl, M. A biosimilar industry view on the implementation of the WHO guidelines on evaluating similar biotherapeutic products. Biologicals. 2011;39:297–9.Google Scholar
Rettenbacher, M, Andersen, AN, Garcia-Velasco, JA et al. A multi-centre phase 3 study comparing efficacy and safety of Bemfola(®) versus Gonal-f(®) in women undergoing ovarian stimulation for IVF. Reprod Biomed Online. 2015;30:504–13.Google Scholar
Olsson, H, Sandstrom, R, Grundemar, L. Different pharmacokinetic and pharmacodynamic properties of recombinant follicle-stimulating hormone (rFSH) derived from a human cell line compared with rFSH from a non-human cell line. J Clin Pharmacol 2014;54:12991307.CrossRefGoogle ScholarPubMed
Arce, JC, Andersen, AN, Fernández-Sánchez, M et al. Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antimüllerian hormone-stratified, dose-response trial in women undergoing in vitro fertilization/intracytoplasmic sperm injection. Fertil Steril. 2014;102:1633–40.Google Scholar
Nyboe Andersen, A, Nelson, SM, Fauser, BC et al. ESTHER-1 study group. Individualized versus conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial. Fertil Steril. 2017;107:387–96.Google Scholar
Abd-Elaziz, K, Duijkers, I, Stöckl, L et al. A new fully human recombinant FSH (follitropin epsilon): two phase I randomized placebo and comparator-controlled pharmacokinetic and pharmacodynamic trials. Hum Reprod. 2017;7:19.Google Scholar
Baird, DT. A model for follicular selection and ovulation: lessons from superovulation. J Steroid Biochem. 1987;27:1523.Google Scholar
Sunkara, SK, Rittenberg, V, Raine-Fenning, N et al. Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles. Hum Reprod. 2011;26:1768–74.Google Scholar
Bosch, E, Labarta, E, Crespo, J et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod. 2010;25:2092–100.Google Scholar
Porter, RN, Smith, W, Craft, IL, Abdulwahid, NA, Jacobs, HS. Induction of ovulation for in-vitro fertilisation using buserelin and gonadotropins. Lancet. 1984;2(8414):1284–5.Google Scholar
Fleming, R, Adam, AH, Barlow, DH et al. A new systematic treatment for infertile women with abnormal hormone profiles. Br J Obstet Gynaecol. 1982;89:80–3.Google Scholar
Howles, CM, Macnamee, MC, Edwards, RG, Goswamy, R, Steptoe, PC. Effect of high tonic levels of luteinising hormone on outcome of in-vitro fertilisation. Lancet. 1986;2(8505):521–2.Google Scholar
Kol, S, Muchtar, M. Recombinant gonadotrophin-based, ovarian hyperstimulation syndrome-free stimulation of the high responder: suggested protocol for further research. Reprod Biomed Online. 2005;10:575–7.Google Scholar
Humaidan, P, Bredkjaer, HE, Bungum, L, Bungum, M, Grøndahl, ML, Westergaard, L,Andersen, CY. GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF/ICSI cycles: a prospective randomized study. Hum Reprod. 2005;20:1213–20.Google Scholar
Devroey, P, Polyzos, NP, Blockeel, C. An OHSS-Free Clinic by segmentation of IVF treatment. Hum Reprod. 2011;26:2593–7.CrossRefGoogle ScholarPubMed
Broekmans, FJ, de Ziegler, D, Howles, CM et al. The antral follicle count: practical recommendations for better standardization. Fertil Steril. 2010;94:1044–51.Google Scholar
Nelson, SM, Yates, RW, Lyall, H et al. Anti-Müllerian hormone-based approach to controlled ovarian stimulation for assisted conception. Hum Reprod. 2009;24:867–75.Google ScholarPubMed
Cobo, A, Garrido, N, Pellicer, A, Remohí, J. Six years’ experience in ovum donation using vitrified oocytes: report of cumulative outcomes, impact of storage time, and development of a predictive model for oocyte survival rate. Fertil Steril. 2015;104:1426–34.Google Scholar
Fauser, BC, Diedrich, K, Devroey, P. Predictors of ovarian response: progress towards individualized treatment in ovulation induction and ovarian stimulation. Hum Reprod Update 2008;14:114.Google Scholar
Aboulghar, MA, Mansour, RT. Ovarian hyperstimulation syndrome: classifications and critical analysis of preventive measures. Hum Reprod Update 2003;9:275–89.CrossRefGoogle ScholarPubMed
Humaidan, P, Engmann, L, Benadiva, C. Luteal phase supplementation after gonadotropin-releasing hormone agonist trigger in fresh embryo transfer: the American versus European approaches. Fertil Steril. 2015;103:879–85.Google Scholar
Dosouto, C, Haahr, T, Humaidan, P. Gonadotropin-releasing hormone agonist (GnRHa) trigger – State of the art. Reprod Biol. 2017;17:18.Google Scholar

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