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Chapter 2 - The Biology of Agitation

Published online by Cambridge University Press:  09 March 2017

Scott L. Zeller
Affiliation:
University of California, Riverside
Kimberly D. Nordstrom
Affiliation:
Denver Health Medical Center, Colorado
Michael P. Wilson
Affiliation:
University of California, San Diego
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Publisher: Cambridge University Press
Print publication year: 2017

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References

Ambar, G. and Chiavegatto, S.. (2009). “Anabolic-androgenic steroid treatment induces behavioral disinhibition and downregulation of serotonin receptor messenger RNA in the prefrontal cortex and amygdala of male mice.” Genes Brain Behav, 8, 161173.Google Scholar
Andersen, M. B., Werge, T., and Fink-Jensen, A.. (2007). “The acetylcholinesterase inhibitor galantamine inhibits d-amphetamine-induced psychotic-like behavior in Cebus monkeys.” J Pharmacol Exp Ther, 321, 11791182.CrossRefGoogle ScholarPubMed
Benus, R. F., Bohus, B., Koolhaas, J. M., et al. (1991). “Heritable variation for aggression as a reflection of individual coping strategies.” Experientia, 47, 10081019.CrossRefGoogle ScholarPubMed
Bethea, C. L., Phu, K., Kim, A., et al. (2015). “Androgen metabolites impact CSF amines and axonal serotonin via MAO-A and -B in male macaques.” Neuroscience, 301, 576589.Google Scholar
Bosboom, J. L., Stoffers, D., and Wolters, E.. (2003). “The role of acetylcholine and dopamine in dementia and psychosis in Parkinson’s disease.” J Neural Transm Suppl, 185195.CrossRefGoogle Scholar
Bosch, O. J., Dabrowska, J., Modi, M. E., et al. (2016). “Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles.” Psychoneuroendocrinology, 64, 6678.CrossRefGoogle ScholarPubMed
Brunner, H. G., Nelen, M., Breakefield, X. O., et al. (1993). “Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.” Science, 262, 578580.CrossRefGoogle ScholarPubMed
Buades-Rotger, M. and Gallardo-Pujol, D.. (2014). “The role of the monoamine oxidase A gene in moderating the response to adversity and associated antisocial behavior: a review.” Psychol Res Behav Manag, 7, 185200.Google Scholar
de Almeida, R. M., Ferrari, P. F., Parmigiani, S., et al. (2005). “Escalated aggressive behavior: dopamine, serotonin and GABA.” Eur J Pharmacol, 526, 5164.Google Scholar
de Boer, S. F., van der Vegt, B. J. and Koolhaas, J. M.. (2003). “Individual variation in aggression of feral rodent strains: a standard for the genetics of aggression and violence?Behav Genet, 33, 485501.Google Scholar
de Wied, D., Diamant, M., and Fodor, M.. (1993). “Central nervous system effects of the neurohypophyseal hormones and related peptides.” Front Neuroendocrinol, 14, 251302.Google Scholar
DeLong, M. R. and Wichmann, T.. (2007). “Circuits and circuit disorders of the basal ganglia.” Arch Neurol, 64, 2024.Google Scholar
Di Chiara, G., Bassareo, V., Fenu, S., et al. (2004). “Dopamine and drug addiction: the nucleus accumbens shell connection.” Neuropharmacology, 47 Suppl 1, 227241.Google Scholar
Eme, R. (2010). “Male life-course-persistent antisocial behavior: the most important pediatric mental health problem.” Arch Pediatr Adolesc Med, 164, 486487.Google Scholar
Fava, M., Johe, K., Ereshefsky, L., et al. (2015). “A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients.” Mol Psychiatry.Google Scholar
Gallagher, D. and Herrmann, N.. (2014). “Antiepileptic drugs for the treatment of agitation and aggression in dementia: do they have a place in therapy?Drugs, 74, 17471755.Google Scholar
Haney, M. (2005). “The marijuana withdrawal syndrome: diagnosis and treatment.” Curr Psychiatry Rep, 7, 360366.Google Scholar
Hardy, J., Cowburn, R., Barton, A., et al. (1987). “Region-specific loss of glutamate innervation in Alzheimer’s disease.” Neurosci Lett, 73, 7780.Google Scholar
Herrmann, N., Cappell, J., Eryavec, G. M., et al. (2011). “Changes in nursing burden following memantine for agitation and aggression in long-term care residents with moderate to severe Alzheimer’s disease: an open-label pilot study.” CNS Drugs, 25, 425433.Google Scholar
Hirota, T., Veenstra-Vanderweele, J., Hollander, E., et al. (2014). “Antiepileptic medications in autism spectrum disorder: a systematic review and meta-analysis.” J Autism Dev Disord, 44, 948957.Google Scholar
Hshieh, T. T., Fong, T. G., Marcantonio, E. R., et al. (2008). “Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence.” J Gerontol A Biol Sci Med Sci, 63, 764772.Google Scholar
Kiecolt-Glaser, J. K., Derry, H. M., and Fagundes, C. P.. (2015). “Inflammation: depression fans the flames and feasts on the heat.” Am J Psychiatry, 172, 10751091.Google Scholar
Kim, I. H., Rossi, M. A., Aryal, D. K., et al. (2015). “Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.” Nat Neurosci, 18, 883891.Google Scholar
Kirby, M. and Lawlor, B. A.. (1995). “Biologic markers and neurochemical correlates of agitation and psychosis in dementia.” J Geriatr Psychiatry Neurol, 8 Suppl 1, S27.CrossRefGoogle ScholarPubMed
Kumsta, R. and Heinrichs, M.. (2013). “Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system.” Curr Opin Neurobiol, 23, 1116.Google Scholar
Kumsta, R., Hummel, E., Chen, F. S., et al. (2013). “Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience.” Front Neurosci, 7, 83.CrossRefGoogle ScholarPubMed
Li, J. J. and Lee, S. S.. (2010). “Latent class analysis of antisocial behavior: interaction of serotonin transporter genotype and maltreatment.” J Abnorm Child Psychol, 38, 789801.Google Scholar
Liechti, M. (2015). “Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signaling.” Swiss Med Wkly, 145, w14043.Google ScholarPubMed
Lindenmayer, J. P. (2000). “The pathophysiology of agitation.” J Clin Psychiatry, 61 Suppl 14, 510.Google Scholar
Liu, C. S., Chau, S. A., Ruthirakuhan, M., et al. (2015). “Cannabinoids for the treatment of agitation and aggression in Alzheimer’s disease.” CNS Drugs, 29, 615623.CrossRefGoogle ScholarPubMed
Maes, M., Scharpe, S., Verkerk, R., et al. (1995). “Seasonal variation in plasma L-tryptophan availability in healthy volunteers: relationships to violent suicide occurrence.” Arch Gen Psychiatry, 52, 937946.Google Scholar
Maneta, E. and Garcia, G.. (2014). “Psychiatric manifestations of Anti-NMDA receptor encephalitis: neurobiological underpinnings and differential diagnostic implications.” Psychosomatics, 55, 3744.Google Scholar
Meldrum, B. S. (2000). “Glutamate as a neurotransmitter in the brain: review of physiology and pathology.” J Nutr, 130, 1007S1015S.Google Scholar
Miczek, K. A., Fish, E. W., De Bold, J. F., et al. (2002). “Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems.” Psychopharmacology (Berl), 163, 434458.Google Scholar
Myers, A. J., Williams, L., Gatt, J. M., et al. (2014). “Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress.” J Psychiatr Res, 59, 93100.Google Scholar
Nichols, C. D. and Sanders-Bush, E.. (2004). “Molecular genetic responses to lysergic acid diethylamide include transcriptional activation of MAP kinase phosphatase-1, C/EBP-beta and ILAD-1, a novel gene with homology to arrestins.” J Neurochem, 90, 576584.Google Scholar
O’Driscoll, K. and Leach, J. P.. (1998). “‘No longer Gage’: an iron bar through the head. Early observations of personality change after injury to the prefrontal cortex.” BMJ, 317, 16731674.Google Scholar
Picciotto, M. R., Lewis, A. S., van Schalkwyk, G. I., et al. (2015). “Mood and anxiety regulation by nicotinic acetylcholine receptors: a potential pathway to modulate aggression and related behavioral states.” Neuropharmacology, 96, 235243.Google Scholar
Porsteinsson, A. P., Keltz, M. A. and Smith, J. S.. (2014). “Role of citalopram in the treatment of agitation in Alzheimer’s disease.” Neurodegener Dis Manag, 4, 345349.Google Scholar
Radley, J. J., Kabbaj, M., Jacobson, L., et al. (2011). “Stress risk factors and stress-related pathology: neuroplasticity, epigenetics and endophenotypes.” Stress, 14, 481497.Google Scholar
Ramirez, B. G., Blazquez, C., Gomez del Pulgar, T., et al. (2005). “Prevention of Alzheimer’s disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation.” J Neurosci, 25, 19041913.Google Scholar
Sachdev, P. and Kruk, J.. (1996). “Restlessness: the anatomy of a neuropsychiatric symptom.” Aust N Z J Psychiatry, 30, 3853.Google Scholar
Sachdev, P. S., Chen, X., Joscelyne, A., et al. (2007). “Amygdala in stroke/transient ischemic attack patients and its relationship to cognitive impairment and psychopathology: the Sydney Stroke Study.” Am J Geriatr Psychiatry, 15, 487496.Google Scholar
Shibuya-Tayoshi, S., Tsuchiya, K., Seki, Y., et al. (2005). “Presenile dementia mimicking Pick’s disease: an autopsy case of localized amygdala degeneration with character change and emotional disorder.” Neuropathology, 25, 235240.Google Scholar
Siegel, A. and Victoroff, J.. (2009). “Understanding human aggression: new insights from neuroscience.” Int J Law Psychiatry, 32, 209215.Google Scholar
Siegel, J. Z. and Crockett, M. J.. (2013). “How serotonin shapes moral judgment and behavior.” Ann N Y Acad Sci, 1299, 4251.Google Scholar
Siepmann, T., Penzlin, A. I., Kepplinger, J., et al. (2015). “Selective serotonin reuptake inhibitors to improve outcome in acute ischemic stroke: possible mechanisms and clinical evidence.” Brain Behav, 5, e00373.Google Scholar
Smith, C. C., Gibbs, T. T., and Farb, D. H.. (2014). “Pregnenolone sulfate as a modulator of synaptic plasticity.” Psychopharmacology (Berl), 231, 35373556.Google Scholar
Taft, C. T., Creech, S. K., and Kachadourian, L.. (2012). “Assessment and treatment of posttraumatic anger and aggression: a review.” J Rehabil Res Dev, 49, 777788.Google Scholar
Takahashi, A., Shiroishi, T., and Koide, T.. (2014). “Genetic mapping of escalated aggression in wild-derived mouse strain MSM/Ms: association with serotonin-related genes.” Front Neurosci, 8, 156.Google Scholar
Takahashi, A., Sugimoto, H., Kato, S., et al. (2015). “Mapping of genetic factors that elicit intermale aggressive behavior on mouse chromosome 15: intruder effects and the complex genetic basis.” PLoS One, 10, e0137764.Google Scholar
Terracciano, A., Esko, T., Sutin, A. R., et al. (2011). “Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking.” Transl Psychiatry, 1, e49.Google Scholar
Trzepacz, P. T., Yu, P., Bhamidipati, P. K., et al. (2013). “Frontolimbic atrophy is associated with agitation and aggression in mild cognitive impairment and Alzheimer’s disease.” Alzheimers Dement, 9, S95S104 e101.Google Scholar
Van den Elsen, G. A., Ahmed, A. I., Verkes, R. J., et al. (2015). “Tetrahydrocannabinol for neuropsychiatric symptoms in dementia: a randomized controlled trial.” Neurology, 84, 23382346.Google Scholar
Van der Jeugd, A., Blum, D., Raison, S., et al. (2013). “Observations in THY-Tau22 mice that resemble behavioral and psychological signs and symptoms of dementia.” Behav Brain Res, 242, 3439.Google Scholar
Van der Mast, R. C. and Fekkes, D.. (2000). “Serotonin and amino acids: partners in delirium pathophysiology?Semin Clin Neuropsychiatry, 5, 125131.Google Scholar
Volk, D. W., Chitrapu, A., Edelson, J. R., et al. (2015). “Molecular mechanisms and timing of cortical immune activation in schizophrenia.” Am J Psychiatry, 172, 11121121.Google Scholar
Waters, E., Morrall, M. C. and Murdoch-Eaton, D.. (2010). “Archimedes. Question 3. Should carbamazepine be administered to manage agitation and aggressive behaviour following paediatric acquired brain injury?Arch Dis Child, 95, 950952.Google Scholar
Wilkinson, S. T., Stefanovics, E. and Rosenheck, R. A.. (2015). “Marijuana use is associated with worse outcomes in symptom severity and violent behavior in patients with posttraumatic stress disorder.” J Clin Psychiatry, 76, 11741180.Google Scholar
Wong, P., Chang, C. C., Marx, C. E., et al. (2012). “Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.” PLoS One, 7, e51455.Google Scholar
Zalcman, S. S. and Siegel, A.. (2006). “The neurobiology of aggression and rage: role of cytokines.” Brain Behav Immun, 20, 507514.Google Scholar
Zhang, Y., Traskman-Bendz, L., Janelidze, S., et al. (2012). “Toxoplasma gondii immunoglobulin G antibodies and nonfatal suicidal self-directed violence.” J Clin Psychiatry, 73, 10691076.Google Scholar
Ziv, L., Muto, A., Schoonheim, P. J., et al. (2013). “An affective disorder in zebrafish with mutation of the glucocorticoid receptor.” Mol Psychiatry, 18, 681691.Google Scholar

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