ACTIVE Writing Group of the ACTIVE Investigators (2006). Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): A randomized controlled trial. Lancet 367:1903–1912CrossRefGoogle Scholar

Amerenco, P, Labreuche, J, Lavallee, P et al. (2004). Statins in stroke prevention and carotid atherosclerosis: Systematic review and up-to-date meta-analysis. Stroke 35:2902–2909Google Scholar

Amarenco, P, Bogousslavsky, J, Callahan, A III et al. (2006). High-dose atorvastatin after stroke or transient ischemic attack. New England Journal of Medicine 355:549–559Google Scholar

Amarenco, P, Goldstein, LB, Szarek, M et al. (2007). Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial. Stroke 38:3198–3204Google Scholar

Amarenco, P, Labreuche, J (2009). Lipid management in the prevention of stroke: Review and updated meta-analysis of statins for stroke prevention. Lancet Neurology 8:453–463Google Scholar

Amarenco, P, Albers, GW, Denison, H et al. (2017). Efficacy and safety of ticagrelor versus aspirin in acute stroke or transient ischemic attack of atherosclerotic origin: A subgroup analysis of SOCRATES, a randomised, double-blind, controlled trial. Lancet Neurology 16:301–310Google Scholar

Antithrombotic Trialists’ (ATT) Collaboration (2009). Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomized trials. Lancet 373:1849–1860Google Scholar

Apostolakis, S, Sullivan, RM, Olshansky, B et al. (2013). Factors affecting quality of anticoagulation control among patients with atrial fibrillation on warfarin: The SAMe-TT₂R₂ score. Chest 144:1555–1563Google Scholar

Bai, Y, Deng, H, Shantsila, A et al. (2017). Rivaroxaban versus dabigatran or warfarin in real-world studies of stroke prevention in atrial fibrillation: Systematic review and meta-analysis. Stroke (epub ahead of print)Google Scholar

Berger, PB, Bhatt, DL, Fuster, V et al. (2010). Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk actors for vascular disease: Results from the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial. Circulation 121:2575–2583Google Scholar

Bhatt, DL, Flather, MD, Hacke, W et al. (2007). Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. Journal of the American College of Cardiologists 49:1982–1988Google Scholar

Bloomfield, RH, Davenport, J, Babikian, V et al. (2001). Reduction in stroke with gemfibrozil in men with coronary heart disease and low HDL cholesterol: The Veterans Affairs HDL Intervention Trial (VA-HIT). Circulation 103:2828–2833CrossRefGoogle Scholar

CADISS Trial Investigators (2015). Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): A randomised trial. Lancet Neurology 14:361–367Google Scholar

Canadian Cooperative Study Group (1978). A randomized trial of aspirin and sulfinpyrazone in threatened stroke. New England Journal of Medicine 299:53–59Google Scholar

CAPRIE Steering Committee (1996). A randomised blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348:1329–1339Google Scholar

Carnicelli, AP, Caterina, RD, Halperin, JL et al. (2017). Edoxaban for the prevention of thromboembolism in patients with atrial fibrillation and bioprosthetic valves. Circulation (epub ahead of print)Google Scholar

Chan, PH, Chan, EW, Li, WH et al. (2016). Use of the SAMe-TT2R2 Score to predict good anticoagulation control with warfarin in Chinese patients with atrial fibrillation: relationship to ischemic stroke incidence. PLoS One 11:e0150674Google Scholar

Chimowitz, MI, Lynn, MJ, Howlett-Smith, H et al. (2005). Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis. New England Journal of Medicine 352:1305–1316Google Scholar

Chimowitz, MI, Lynn, MJ, Derdeyn, CP et al. (2011). Stenting versus aggressive medical therapy for intracranial artery stenosis. New England Journal of Medicine 365:993–1003Google Scholar

Collins, R, Armitage, J, Parish, S et al. (2004). Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20 536 people with cerebrovascular disease or other high-risk conditions. Lancet 363:757–767Google Scholar

Connolly, SJ, Ezekowitz, MD, Yusuf, S et al. (2009). Dabigatran versus warfarin in patients with atrial fibrillation. New England Journal of Medicine 361:1139–1151Google Scholar

Connolly, SJ, Eikelboom, J, Joyner, C et al. (2011). Apixaban in patients with atrial fibrillation. New England Journal of Medicine 364:806–817CrossRefGoogle ScholarPubMed

Connolly, SJ, Milling, TJ Jr, Eikelboom, JW et al. (2016). Andexanet alfa for acute major bleeding associated with factor Xa inhibitors. New England Journal of Medicine 375:1131–1141Google Scholar

Corvol, JC, Bouzamondo, A, Sirol, M et al. (2003). Differential effects of lipid-lowering therapies on stroke prevention: A meta-analysis of randomized trials. Archives of Internal Medicine 163:669–676Google Scholar

Diener, HC, Cunha, L, Forbes, C et al. (1996). European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. Journal of the Neurological Sciences 143:1–13Google Scholar

Diener, HC, Bogousslavsky, J, Brass, LM et al. (2004). Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): Randomised double-blind placebo-controlled trial. Lancet 364:331–337CrossRefGoogle ScholarPubMed

Diener, HC, Connolly, S, Ezekowitz, MD et al. (2010). Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ishemic attack or stroke: A subgroup analysis of the RE-LY trial. Lancet Neurology 9:1157–1163Google Scholar

Easton, JD, Lopes, RD, Bahit, MC et al. (2012) Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischemic attack: A subgroup analysis of the ARISTOTLE trial. Lancet Neurology 11:503–511Google Scholar

Eikelboom, JW, Connolly, SJ, Brueckmann, M et al. (2013). Dabigatran versus warfarin in patients with mechanical heart valves. New England Journal of Medicine 369:1206–1214Google Scholar

ESPRIT Study Group, Halkes, PH, van Gijn, J et al. (2007). Medium intensity oral anticoagulants versus aspirin after cerebral ischemic of arterial origin (ESPRIT): A randomized controlled trial. Lancet Neurology 6:115–124Google Scholar

Ettehad, D, Emdin, CA, Kiran, A et al. (2016). Blood pressure lowering for prevention of cardiovascular disease and death: A systematic review and meta-analysis. Lancet 387:957–967CrossRefGoogle Scholar

Freedman, B, Gersh, BJ, Lip, GY (2015). Misperceptions of aspirin efficacy and safety may perpetuate anticoagulant underutilization in atrial fibrillation. European Heart Journal 36:653–656Google Scholar

Giugliano, RP, Ruff, CT, Braunwald, E et al. (2013). Edoxaban versus warfarin in patients with atrial fibrillation. New England Journal of Medicine 369:2093–2104Google Scholar

Giugliano, RP, Sabatine, MS (2015). Are PCSK9 inhibitors the next breakthrough in the cardiovascular field? Journal of the American College of Cardiology 65:2638–2651CrossRefGoogle ScholarPubMed

Goldstein, LB, Amarenco, P, Szarek, S et al. (2008). Hemorrhagic stroke in Stroke Prevention by Aggressive Reduction in Cholesterol Levels study. Neurology 70:2364–2370Google Scholar

Granger, GB, Alexander, JH, McMurray, JJ et al. (2011). Apixaban versus warfarin in patients with atrial fibrillation. New England Journal of Medicine 365:981–992Google Scholar

Halkes, PH, van Gijn, J for the ESPRIT Study Group (2006). Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): Randomised controlled trial. Lancet 367:1665–1673 [Erratum in Lancet (2007) 369:274]Google Scholar

Hankey, GJ, Patel, MR, Stevens, SR et al. (2012). Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischemic attack: A subgroup analysis of ROCKET AF. Lancet Neurology 11:315–322Google Scholar

Hart, RG, Pearce, LA, Aguilar, MI (2007). Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Annals of Internal Medicine 146:857–867Google Scholar

Heidbuchel, H, Verhamme, P, Alings, M et al. (2015). Updated European Heart Rhythm Association Practical Guide on the use of non-vigtmain K antagnoist anticoagulants in patients with non-valvular atrial fibrillation. Europace 17:1467–1507Google Scholar

Kamal, AK, Naqvi, I, Husain, MR et al. (2011). Cilostazol versus aspirin for secondary prevention of vascular events after stroke of arterial origin. Cochrane Database of Systematic Reviews 1:CD008076Google Scholar

Kernan, WN, Ovbiagele, B, Black, HR et al. (2014). Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 45:2160–2236Google Scholar

Kernan, WN, Viscoli, CM, Furie, KL et al. (2016). Pioglitazone after ischemic stroke or transient ischemic attack. New England Journal of Medicine 374:1321–1331Google Scholar

Kirchhof, P, Benussi, S, Kotecha, D et al. (2016). 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Heart Journal 37:2893–2962Google Scholar

Johnston, SC, Amarenco, P, Albers, GW et al. (2016). Ticagrelor versus aspirin in acute stroke or transient ischemic attack. New England Journal of Medicine 375:35–43Google Scholar

Lamberts, M, Gislason, GH, Lip, GY et al. (2014). Antiplatelet therapy for stable coronary artery disease in atrial fibrillation patients taking an oral anticoagulant: A nationwide cohort study. Circulation 129:1577–1585Google Scholar

Leonardi-Bee, J, Bath, PM, Bousser, MG et al. (2005) Dipyridamole for preventing recurrence ischemic stroke and other vascular events: A meta-analysis of individual patient data from randomized controlled trials. Stroke 36:162–168Google Scholar

Lewington, S, Whitlock, G, Clarke, R et al. (2007). Blood cholesterol and vascular mortality by age, sex, and blood pressure: A meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 370:1829–1839Google Scholar

Lip, GY, Nieuwlaat, R, Pisters, R et al. (2010a). Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: The Euro Heart Survey on Atrial Fibrillation. Chest 137:263–272Google Scholar

Lip, GY, Frison, L, Halperin, JL et al. (2010b). Comparative validation of a novel risk score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: The HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drug/Alcohol Concomitantly) score. Journal of American College of Cardiology 57:173–180Google Scholar

Lip, GY, Windecker, S, Huber, K et al. (2014). Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary or valve interventions: A joint consensus document of the European Society of Cardiology Working Group on Thrombosis, European Heart Rhythm Association (EHRA), European Association of Percutaneous Cardiovascular Interventions (EAPCI) and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS) and Asia-Pacific Heart Rhythm Society (APHRS). European Heart Journal 35:3155–3179Google Scholar

Liu, L, Wang, Z, Gong, L et al. (2009). Blood pressure reduction for the secondary prevention of stroke: A Chinese trial and a systematic review of the literature. Hypertension Research 32:1032–1040Google Scholar

Mant, J, Hobbs, FD, Fletcher, K et al. (2007) Midland Research Practices Network (MidReC). Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): A randomised controlled trial. Lancet 370:493–503Google Scholar

Migrino, RQ, Bowers, M, Harmann, L et al. (2011). Carotid plaque regression following 6-month statin therapy assessed by 3 T cardiovascular magnetic resonance: Comparison with ultrasound intima media thickness. Journal of Cardiovascular Magnetic Resonance 13:37Google Scholar

Mohr, JP, Thompson, JL, Lazar, RM et al. (2001). A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. New England Journal of Medicine 345:1444–1451Google Scholar

Odden, MC, McClure, LA, Sawaya, BP et al. (2016). Achieved blood pressure and outcomes in the Secondary Prevention of Small Subcortical Strokes Trial. Hypertension 67:63–69Google Scholar

Patel, MR, Mahaffey, KW, Garg, J et al. (2011). Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. New England Journal of Medicine 365:883–891Google Scholar

Pisters, R, Lane, DA, Nieuwlaat, R et al. (2010). A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: The Euro Heart Survey. Chest 138:1093–1100Google Scholar

Pollack, CV Jr., Reilly, PA, Eikelboom, J et al. (2015). Idarucizumab for dabigatran reversal. New England Journal of Medicine 373:511–520Google Scholar

Powers, WJ, Rabinstein, AA, Ackerson, T et al. (2018). 2018 Guidelines for the early management of patients with acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 49:e46–e110Google Scholar

PROGRESS Collaborative Group (2001). Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attacks. Lancet 358:1033–1041Google Scholar

Rash, A, Downes, T, Portner, R et al. (2007). A randomised controlled trial of warfarin versus aspirin for stroke prevention in octogenarians with atrial fibrillation (WASPO). Age Ageing 36:151–156Google Scholar

Rost, NS, Giugliano, RP, Ruff, CT et al. (2016). Outcomes with edoxaban versus warfarin in patients with previous cerebrovascular events: Findings from Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction. Stroke 47:2075–2082Google Scholar

Rothwell, PM, Giles, MF, Chandratheva, A et al. (2007). Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): A prospective population-based sequential comparison. Lancet 370:1432–1442CrossRefGoogle ScholarPubMed

Rothwell, PM, Howard, SC, Dolan, E et al. (2010). Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 375:895–905Google Scholar

Rothwell, PM, Algra, A, Chen, Z et al. (2016). Effects of aspirin on risk and severity of early recurrent stroke after transient ischemic attack and ischemic stroke: Time-course analysis of randomized trials. Lancet 388:365–375Google Scholar

Ruff, CT, Giugliano, RP, Braunwald, E et al. (2014). Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: A meta-analysis of randomized trials. Lancet 383:955–962Google Scholar

Sabatine, MS, Giugliano, RP, Keech, AC et al. (2017). Evolocumab and clinical outcomes in patients with cardiovascular disease. New England Journal of Medicine 376:1713–1722Google Scholar

Sacco, RL, Diener, HC, Yusuf, S et al. (2008). Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. New England Journal of Medicine 359:1238–1251Google Scholar

Seidu, S, Achana, FA, Gray, LJ et al. (2016). Effects of glucose-lowering and multifactorial interventions on cardiovascular and mortality outcomes: A meta-analysis of randomized control trials. Diabetic Medicine 33:280–289Google Scholar

Siontis, KC, Yao, X, Gersh, BJ et al. (2017). Direct oral anticoagulants in patients with atrial fibrillation and valvular heart disease other than significant mitral stenosis and mechanical valves. Circulation 135:714–716Google Scholar

Sillesen, H, Amarenco, P, Hennerici, MG et al. (2008). Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: A secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial. Stroke 39:3297–3302Google Scholar

Sivenius, J, Riekkinen, PJ, Smets, P et al. (1991). The European Stroke Prevention Study (ESPS): Results by arterial distribution. Annals of Neurology 29:596–600Google Scholar

SPS3 Investigators (2012). Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. New England Journal of Medicine 367:817–825Google Scholar

Stroke Prevention in Atrial Fibrillation Investigators (1991). Stroke prevention in atrial fibrillation study: Final results. Circulation 84:527–539Google Scholar

Stroke Prevention in Reversible Ischemic Trial (SPIRIT) Study Group (1997). A randomized trial of anticoagulants versus aspirin after cerebral ischemic of presumed arterial origin. Annals of Neurology 42:857–865Google Scholar

Sudlow, CL, Mason, G, Maurice, JB et al. (2009). Thienopyridine derivatives versus aspirin for preventing stroke and other serious vascular events in high vascular risk patients. Cochrane Database of Systematic Reviews 4:CD001246Google Scholar

Verheugt, FW, Granger, CB (2015). Oral anticoagulants for stroke prevention in atrial fibrillation: Current status, special situations, and unmet needs. Lancet 386:303–310Google Scholar

Wang, Y, Wang, Y, Zhao, X et al. (2013). Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. New England Journal of Medicine 369:11–19Google Scholar

Webb, AJ, Fischer, U, Mehta, Z et al. (2010). Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: A systematic review and meta-analysis. Lancet 375:906–915Google Scholar

Webb, AJ, Rothwell, PM (2011). Effect of dose and combination of antihypertensives on interindividual blood pressure variability: A systematic review. Stroke 42:2850–2865Google Scholar

Wong, KS, Wang, Y, Leng, X et al. (2013). Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: An updated systematic review and meta-analysis. Circulation 128:1656–1666Google Scholar

Adhiyaman, V, Alexander, S (2007). Cerebral hyperperfusion syndrome following carotid endarterectomy. Quarterly Journal of Medicine 100:239–244Google Scholar

Andrews, BT, Levy, ML, Dillon, W et al. (1987). Unilateral normal perfusion pressure breakthrough after carotid endarterectomy: Case report. Neurosurgery 21:568–571Google Scholar

Babu, MA, Meissner, I, Meyer, FB (2013). The durability of carotid endarterectomy: Long-term results for restenosis and stroke. Neurosurgery 72:835–838Google Scholar

Barnett, HJM, Plum, F, Walton, JN (1984). Carotid endarterectomy: An expression of concern. Stroke 15:941–943Google Scholar

Barnett, HJM, Taylor, DW, Eliasziw, M for the North American Symptomatic Carotid Endarterectomy Trial Collaborators (1998). Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. New England Journal of Medicine 339:1415–1425CrossRefGoogle ScholarPubMed

Belardi, P, Lucertini, G, Ermirio, D (2003). Stump pressure and transcranial Doppler for predicting shunting in carotid endarterectomy. European Journal of Vascular Endovascular Surgery 25:164–167Google Scholar

Bo, M, Massaia, M, Speme, S et al. (2006). Risk of cognitive decline in older patients after carotid endarterectomy: An observational study. Journal of the American Geriatric Society 54:932–936Google Scholar

Bond, R, Warlow, CP, Naylor, R et al. (2002a). Variation in surgical and anaesthetic technique and associations with operative risk in the European Carotid Surgery Trial: Implications for trials of ancillary techniques. European Journal of Vascular Endovascular Surgery 23:117–126Google Scholar

Bond, R, Rerkasem, K, Rothwell, PM (2002b). Routine or selective carotid artery shunting for carotid endarterectomy. Cochrane Database of Systematic Reviews 2:CD000190Google Scholar

Bond, R, Narayan, S, Rothwell, PM et al. (2002c). Clinical and radiological risk factors for operative stroke and death in the European Carotid Surgery Trial. European Journal of Vascular Endovascular Surgery 23:108–116Google Scholar

Bond, R, Rerkasem, K, Rothwell, PM (2003a). A systematic review of the risks of carotid endarterectomy in relation to the clinical indication and the timing of surgery. Stroke 34:2290–2301Google Scholar

Bond, R, Rerkasem, K, Rothwell, PM (2003b). High morbidity due to endarterectomy for asymptomatic carotid stenosis. Cerebrovascular Diseases 16(Suppl 4):65Google Scholar

Bond, R, Rerkasem, K, Shearman, CP et al. (2004). Time trends in the published risks of stroke and death due to endarterectomy for symptomatic carotid stenosis. Cerebrovascular Diseases 18:37–46Google Scholar

Bossema, ER, Brand, N, Moll, FL et al. (2005). Perioperative microembolism is not associated with cognitive outcome three months after carotid endarterectomy. European Journal of Vascular Endovascular Surgery 29:262–268Google Scholar

Breen, JC, Caplan, LR, Dewitt, LD et al. (1996). Brain oedema after carotid surgery. Neurology 46:175–181Google Scholar

Brothers, TE (2005). Initial experience with eversion carotid endarterectomy: Absence of a learning curve for the first 100 patients. Journal of Vascular Surgery 42:429–434Google Scholar

Campbell, WB (1993). Can reported carotid surgical results be misleading?. In Surgery for Stroke. Greenhalgh, GM and Hollier, LH (eds.), pp. 331–337. London: SaundersGoogle Scholar

Cao, P, Giordano, G, De Rango, P for the Collaborators of the EVEREST Study Group (1998). A randomised study on eversion versus standard carotid endarterectomy: Study design and preliminary results: The Everest Trial. Journal of Vascular Surgery 27:595–605Google Scholar

Cao, PG, De Rango, P, Zannetti, S et al. (2001). Eversion versus conventional carotid endarterectomy for preventing stroke. Cochrane Database of Systematic Reviews, 2:CD001921Google Scholar

Cao, P, De Rango, P, Zannetti, S (2002). Eversion versus conventional carotid endarterectomy: A systematic review. European Journal of Vascular and Endovascular Surgery 23:195–201Google Scholar

Carrea, R, Molins, M, Murphy, G (1955). Surgical treatment of spontaneous thrombosis of the internal carotid artery in the neck. Carotid–carotideal anastomosis. Report of a case. Acta Neurologica Latin America 1:71–78Google Scholar

Chambers, BR, Norris, J (1984). The case against surgery for asymptomatic carotid stenosis. Stroke 15:964–967Google Scholar

Chambers, BR, Smidt, V, Koh, P (1994). Hyperfusion post-endarterectomy. Cerebrovascular Diseases 4:32–37Google Scholar

Chiari, H (1905). Uber des verhalten des teilungswinkels der carotis communis bei der endarteritis chronica deformans. Verhandlungen der Deutschen Gesellschaft für Pathologie 9:326–330Google Scholar

Chongruksut, W, Vaniyapong, T, Rerkasem, K (2014). Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring in selective shunting). Cochrane Database of Systematic Reviews 23:CD000190Google Scholar

Cooper, A (1836). Account of the first successful operation performed on the common carotid artery for aneurysm in the year 1808 with the post-mortem examination in the year 1821. Guy’s Hospital Report 1:53–59Google Scholar

Cunningham, E, Bond, R, Mehta, Z et al. (2002). Long-term durability of carotid endarterectomy in the European Carotid Surgery Trial. Stroke 33:2658–2663Google Scholar

Cunningham, EJ, Bond, R, Mayberg, MR et al. (2004). Risk of persistent cranial nerve injury after carotid endarterectomy. Journal of Neurosurgery 101:455–458Google Scholar

Darling, RC, Paty, PSK, Shah, DM et al. (1996). Eversion endarterectomy of the internal carotid artery: Technique and results in 449 procedures. Surgery 120:635–639Google Scholar

DeBakey, ME (1975). Successful carotid endarterectomy for cerebrovascular insufficiency. Nineteen-year follow-up. Journal of the American Medical Association 233:1083–1085Google Scholar

Demirel, S, Attigah, N, Bruijnen, H et al. (2012). Multicenter experience on eversion versus conventional carotid endarterectomy in symptomatic carotid artery stenosis. Stroke 43:1865–1871Google Scholar

De Marinis, M, Zaccaria, A, Faraglia, V et al. (1991). Post-endarterectomy headache and the role of the oculosympathetic system. Journal of Neurology, Neurosurgery and Psychiatry 54:314–317Google Scholar

Dos Santos, JC (1976). From embolectomy to endarterectomy or the fall of a myth. Journal of Cardiovascular Surgery 17:113–128Google Scholar

Eastcott, HHG, Pickering, GW, Rob, CG (1954). Reconstruction of internal carotid artery in a patient with intermittent attacks of hemiplegia. Lancet ii, 994–996Google Scholar

Eliasziw, M, Spence, JD, Barnett, HM for the North American Symptomatic Carotid Endarterectomy Trial (1998). Carotid endarterectomy does not affect long term blood pressure: Observations from the NASCET. Cerebrovascular Diseases 8:20–24Google Scholar

European Carotid Surgery Trialists’ Collaborative Group (1991). MRC European Carotid Surgery Trial: Interim results for symptomatic patients with severe (70–99%) or with mild (0–29%) carotid stenosis. Lancet 337:1235–1243Google Scholar

European Carotid Surgery Trialists’ Collaborative Group (1998). Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST). Lancet 351:1379–1387Google Scholar

Ferguson, GG (1986). Carotid endarterectomy. To shunt or not to shunt? Archives of Neurology 43:615–618Google Scholar

Ferguson, GG, Eliasziw, M, Barr, HWK for the North American Symptomatic Carotid Endarterectomy Trial (NASCET) Collaborators (1999). The North American Symptomatic Carotid Endarterectomy Trial: surgical results in 1415 patients. Stroke 30:1751–1758Google Scholar

Fields, WS, Maslenikov, V, Meyer, JS et al. (1970). Joint study of extracranial arterial occlusion. V. Progress report of prognosis following surgery or nonsurgical treatment for transient cerebral ischaemic attacks and cervical carotid artery lesions. Journal of the American Medical Association 211:1993–2003Google Scholar

Fisher, M (1951). Occlusion of the internal carotid artery. Archives of Neurology and Psychiatry 65:346–377Google Scholar

Fisher, M (1954). Occlusion of the carotid arteries. Archives of Neurology and Psychiatry 72:187–204Google Scholar

Frericks, H, Kievit, J, van Baalen, JM et al. (1998). Carotid recurrent stenosis and risk of ipsilateral stroke: A systematic review of the literature. Stroke 29:244–250Google Scholar

GALA Trial Collaborative Group (2008). General anesthesia versus local anesthesia for carotid surgery (GALA): A multicenter, randomized controlled trial. Lancet 9656:2132–2142Google Scholar

Gaunt, ME, Naylor, AR, Sayers, RD et al. (1993). Sources of air embolisation during carotid surgery: The role of transcranial Doppler ultrasonography. British Journal of Surgery 80:1121Google Scholar

Gillum, RF (1995). Epidemiology of carotid endarterectomy and cerebral arteriography in the United States. Stroke 26:1724–1728Google Scholar

Graver, LM, Mulcare, RJ (1986). Pseudoaneurysm after carotid endarterectomy. Journal of Cardiovascular Surgery 27:294–297Google Scholar

Gurdjian, ES (1979). History of occlusive cerebrovascular disease, I: From Wepfer to Moniz. Archives of Neurology 36:340–343Google Scholar

Gutrecht, JA, Jones, HR (1988). Bilateral hypoglossal nerve injury after bilateral carotid endarterectomy. Stroke 19:261–262Google Scholar

Hafner, DH, Smith, RB, King, OW et al. (1987). Massive intracerebral haemorrhage following carotid endarterectomy. Archives of Surgery 122:305–307Google Scholar

Hamby, WB (1952). Intracranial Aneurysms. Springfield, IL: Charles C ThomasGoogle Scholar

Hartl, WH, Janssen, I, Furst, H (1994). Effect of carotid endarterectomy on patterns of cerebrovascular reactivity in patients with unilateral carotid artery stenosis. Stroke 25:1952–1957Google Scholar

Hunter, GC, Palmaz, JC, Hayashi, HH et al. (1987). The aetiology of symptoms in patients with recurrent carotid stenosis. Archives of Surgery 122:311–315Google Scholar

Ille, O, Woimant, F, Pruna, A et al. (1995). Hypertensive encephalopathy after bilateral carotid endarterectomy. Stroke 26:488–491Google Scholar

Jansen, C, Ramos, LMP, van Heesewijk, JPM et al. (1994a). Impact of microembolism and hemodynamic changes in the brain during carotid endarterectomy. Stroke 25:992–997Google Scholar

Jansen, C, Sprengers, AM, Moll, FL et al. (1994b). Prediction of intracerebral haemorrhage after carotid endarterectomy by clinical criteria and intraoperative transcranial Doppler monitoring. European Journal of Vascular Surgery 8:303–308Google Scholar

Jonas, S (1987). Can carotid endarterectomy be justified? No. Archives of Neurology 44:652–654Google Scholar

Keevil, JJ (1949). David Fleming and the operation for ligation of the carotid artery. British Journal of Surgery 37:92–95Google Scholar

Krul, JMJ, van Gijn, J, Ackerstaff, RGA et al. (1989). Site and pathogenesis of infarcts associated with carotid endarterectomy. Stroke 20:324–328Google Scholar

Kumamaru, H, Jalbert, JJ, Nguyen, LL et al. (2015). Surgeon case volume and 30-day mortality after carotid endarterectomy among contemporary Medicare beneficiaries: Before and after national coverage determination for carotid artery stenting. Stroke 46:1288–1294Google Scholar

Lal, BK (2007). Cognitive function after carotid artery revascularization. Vascular and Endovascular Surgery 41:5–13Google Scholar

Levi, CR, O’Malley, HM, Fell, G et al. (1997). Transcranial Doppler detected cerebral microembolism following carotid endarterectomy. High microembolic signal loads predict postoperative cerebral ischaemia. Brain 120:621–629Google Scholar

Lindblad, B, Persson, NH, Takolander, R et al. (1993). Does low-dose acetylsalicylic acid prevent stroke after carotid surgery? A double-blind, placebo-controlled randomised trial. Stroke 24:1125–1128Google Scholar

Lloyd, AJ, Hayes, PD, London, NJ et al. (2004). Does carotid endarterectomy lead to a decline in cognitive function or health related quality of life? Journal of Clinical and Experimental Neuropsychology 26:817–825Google Scholar

Loftus, CM, Quest, DO (1987). Technical controversies in carotid artery surgery. Neurosurgery 20:490–495Google Scholar

Lopez-Valdes, E, Chang, HM, Pessin, MS et al. (1997). Cerebral vasoconstriction after carotid surgery. Neurology 49:303–304Google Scholar

Lunn, S, Crawley, F, Harrison, MJG et al. (1999). Impact of carotid endarterectomy upon cognitive functioning. A systematic review of the literature. Cerebrovascular Diseases 9:74–81Google Scholar

Maniglia, AJ, Han, DP (1991). Cranial nerve injuries following carotid endarterectomy: An analysis of 336 procedures. Head and Neck 13:121–124Google Scholar

Markus, H, Cullinane, M (2001). Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion. Brain 124:457–467Google Scholar

Markus, HS, Thomson, ND, Brown, MM (1995). Asymptomatic cerebral embolic signals in symptomatic and asymptomatic carotid artery disease. Brain 118:1005–1011Google Scholar

Martin-Negrier, ML, Belleannee, G, Vital, C et al. (1996) Primitive malignant fibrous histiocytoma of the neck with carotid occlusion and multiple cerebral ischemic lesions. Stroke 27:536–537Google Scholar

Mayberg, MR, Wilson, E, Yatsu, F for the Veterans Affairs Cooperative Studies Programe 309 Trialist Group (1991). Carotid endarterectomy and prevention of cerebral ischaemia in symptomatic carotid stenosis. Journal of the American Medical Association 266:3289–3294Google Scholar

Moniz, E (1927). L’encephalographic arterielle: son importance dans la localisation des tumeurs cerebrales. Revue de Neurologie 2:72–90Google Scholar

Moniz, E, Lima, A, de Lacerda, R (1937). Hemiplegies par thrombose de la carotide interne. Presse Medecine 45:977–980Google Scholar

Naylor, AR, Ruckley, CV (1996). Complications after carotid surgery. In Complications in Arterial Surgery. A Practical Approach to Management, Campbell, (ed.), pp. 73–88. Oxford: Butterworth-HeinemannGoogle Scholar

Naylor, AR, Bell, PRF, Ruckley, CV (1992). Monitoring and cerebral protection during carotid endarterectomy. British Journal of Surgery 79:735–741Google Scholar

Naylor, AR, Merrick, MV, Sandercock, PAG et al. (1993a). Serial imaging of the carotid bifurcation and cerebrovascular reserve after carotid endarterectomy. British Journal of Surgery 80:1278–1282Google Scholar

Naylor, AR, Whyman, MR, Wildsmith, JAW et al. (1993b). Factors influencing the hyperaemic response after carotid endarterectomy. British Journal of Surgery 80:1523–1527Google Scholar

Naylor, AR, Evans, J, Thompson, MM et al. (2003). Seizures after carotid endarterectomy: Hyperperfusion, dysautoregulation or hypertensive encephalopathy? European Journal of Vascular Endovascular Surgery 26:39–44Google Scholar

North American Symptomatic Carotid Endarterectomy Trial Collaborators (1991). Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. New England Journal of Medicine 325:445–453Google Scholar

Ojemann, RG, Heros, RC (1986). Carotid endarterectomy. To shunt or not to shunt? Archives of Neurology 43:617–618Google Scholar

Ouriel, K, Shortell, CK, Illig, KA et al. (1999). Intracerebral haemorrhage after carotid endarterectomy: Incidence, contribution to neurologic morbidity, and predictive factors. Journal of Vascular Surgery 29:82–89Google Scholar

Paciaroni, M, Eliasziw, M, Kappelle, LJ for the North American Symptomatic Carotid Endarterectomy Trial (NASCET) Collaborators (1999). Medical complications associated with carotid endarterectomy. Stroke 30:1759–1763Google Scholar

Penzoldt, F (1891). Uber thrombose (autochtone oder embolische) der carotis. Deutschen Archir Für Klinische Medizin 28:80–93Google Scholar

Piepgras, DG, Morgan, MK, Sundt, TM et al. (1988). Intracerebral haemorrhage after carotid endarterectomy. Journal of Neurosurgery 68:532–536Google Scholar

Pokras, R, Dyken, ML (1988). Dramatic changes in the performance of endarterectomy for diseases of the extracranial arteries of the head. Stroke 19:1289–1290Google Scholar

Rerkasem, K and Rothwell, PM (2009). Patch angioplasty versus primary closure for carotid endarterectomy. Cochrane Database of Systematic Reviews 4:CD000160Google Scholar

Rerkasem, K and Rothwell, PM (2010). Patches of different types for carotid patch angioplasty. Cochrane Database of Systematic Reviews 3:CD000071Google Scholar

Riles, TS, Kopelman, I, Imparato, AM (1979). Myocardial infarction following carotid endarterectomy. A review of 683 operations. Surgery 85:249–252Google Scholar

Riles, TS, Imparato, AM, Jacobowitz, GR et al. (1994). The cause of perioperative stroke after carotid endarterectomy. Journal of Vascular Surgery 19:206–216Google Scholar

Rothwell, PM, Warlow, CP (1995). Is self-audit reliable? Lancet 346:1623Google Scholar

Rothwell, PM, Slattery, J, Warlow, CP (1996a). A systematic comparison of the risk of stroke and death due to carotid endarterectomy for symptomatic and asymptomatic stenosis. Stroke 27:266–269Google Scholar

Rothwell, PM, Slattery, J, Warlow, CP (1996b). A systematic review of the risk of stroke and death due to carotid endarterectomy. Stroke 27:260–265CrossRefGoogle ScholarPubMed

Rothwell, PM, Warlow, CP on behalf of the European Carotid Surgery Trialists’ Collaborative Group (1999). Interpretation of operative risks of individual surgeons. Lancet 353:1325Google Scholar

Rothwell, PM, Gutnikov, SA, Warlow, CP for the ECST (2003). Re-analysis of the final results of the European Carotid Surgery Trial. Stroke 34:514–523Google Scholar

Schroeder, T (1988). Hemodynamic significance of internal carotid artery disease. Acta Neurologica Scandinavica 77:353–372Google Scholar

Schroeder, T, Sillesen, H, Sorensen, O et al. (1987). Cerebral hyperfusion following carotid endarterectomy. Journal of Neurosurgery 66:824–829Google Scholar

Shaw, DA, Venables, GS, Cartlidge, NEF et al. (1984). Carotid endarterectomy in patients with transient cerebral ischaemia. Journal of Neurological Sciences 64:45–53CrossRefGoogle ScholarPubMed

Silvestrini, M, Vernieri, F, Pasqualetti, P et al. (2000). Impaired cerebral vasoreactivity and risk of stroke in patients with asymptomatic carotid artery stenosis. Journal of American Medical Association 283:2122–2127CrossRefGoogle ScholarPubMed

Solomon, RA, Loftus, CM, Quest, DO et al. (1986). Incidence and etiology of intracerebral haemorrhage following carotid endarterectomy. Journal of Neurosurgery 64:29–34Google Scholar

Spencer, MP (1997). Transcranial Doppler monitoring and causes of stroke from carotid endarterectomy. Stroke 28:685–691CrossRefGoogle ScholarPubMed

Steed, DL, Peitzman, AB, Grundy, BL et al. (1982). Causes of stroke in carotid endarterectomy. Surgery 92:634–639Google Scholar

Sweeney, PJ Wilbourn, AJ (1992). Spinal accessory (11th) nerve palsy following carotid endarterectomy. Neurology 42:674–675CrossRefGoogle ScholarPubMed

Thompson, JE (1996). The evolution of surgery for the treatment and prevention of stroke. The Willis Lecture. Stroke 27:1427–1434Google Scholar

Truax, BT (1989). Gustatory pain: A complication of carotid endarterectomy. Neurology 39:1258–1260Google Scholar

Tu, JV, Hannan, EL, Anderson, GM et al. (1998). The fall and rise of carotid endarterectomy in the United States and Canada. New England Journal of Medicine 339:1441–1447Google Scholar

Urbinati, S, di Pasquale, G, Andreoli, A et al. (1994). Preoperative noninvasive coronary risk stratification in candidates for carotid endarterectomy. Stroke 25:2022–2027Google Scholar

van Mook, WN, Rennenberg, RJ, Schurink, GW et al. (2005). Cerebral hyperperfusion syndrome. Lancet Neurology 4:877–888Google Scholar

van Zuilen, EV, Moll, FL, Vermeulen, FEE et al. (1995). Detection of cerebral microemboli by means of transcranial Doppler monitoring before and after carotid endarterectomy. Stroke 26:210–213Google Scholar

Vaniyapong, T, Chongruksut, W, Rerkasem, K (2013). Local versus general anesthesia for carotid endarterectomy. Cochrane Database of Systematic Reviews 12:CD000126Google Scholar

Visser, GH, van Huffelen, AC, Wieneke, GH et al. (1997). Bilateral increase in CO reactivity after unilateral carotid endarterectomy. Stroke 28:899–905Google Scholar

Warlow, CP (1984). Carotid endarterectomy: Does it work? Stroke 15:1068–1076Google Scholar

Watanabe, J, Ogata, T, Hamada, O et al. (2014). Improvement of cognitive function after carotid endarterectomy: A new strategy for the evaluation of cognitive function. Journal of Stroke and Cerebrovascular Diseases 23:1332–1336CrossRefGoogle ScholarPubMed

Wennberg, DE, Lucas, FL, Birkmeyer, JD et al. (1998). Variation in carotid endarterectomy mortality in the Medicare population: Trial hospitals, volume, and patient characteristics. Journal of the American Medical Association 279:1278–1281Google Scholar

Wilson, PV, Ammar, AD (2005). The incidence of ischemic stroke versus intracerebral hemorrhage after carotid endarterectomy: A review of 2452 cases. Annals of Vascular Surgery 19:1–4Google Scholar

Winslow, CM, Solomon, DH, Chassin, MR (1988). The appropriateness of carotid endarterectomy. New England Journal of Medicine 318:721–727Google Scholar

Wood, JR (1857). Early history of the operation of ligature of the primitive carotid artery. New York Journal of Medicine July:1–59Google Scholar

Wyeth, JA (1878). Prize essay: Essays upon the surgical anatomy and history of the common, external and internal carotid arteries and the surgical anatomy of the innominate and subclavian arteries. Appendix to Transactions of the American Medical Association (AMA) Philadelphia 29:1–245Google Scholar

Yadav, JS, Roubin, GS, King, P et al. (1996). Angioplasty and stenting for restenosis after carotid endarterectomy. Initial experience. Stroke 27:2075–2079Google Scholar

Yamauchi, H, Fukuyama, H, Nagahama, Y et al. (1996). Evidence of misery perfusion and risk of recurrent stroke in major cerebral arterial occlusive diseases from PET. Journal of Neurology, Neurosurgery and Psychiatry 61:18–25Google Scholar

Yonas, H, Smith, HA, Durham, SR et al. (1993). Increased stroke risk predicted by compromised cerebral blood flow reactivity. Journal of Neurosurgery 79:483–489Google Scholar

Youkey, JR, Clagett, GP, Jaffin, JH et al. (1984). Focal motor seizures complicating carotid endarterectomy. Archives of Surgery 119:1080–1084Google Scholar

Abou-Chebl, A, Reginelli, J, Bajzer, CT et al. (2007). Intensive treatment of hypertension decreases the risk of hyperperfusion and intracerebral hemorrhage following carotid artery stenting. Catheterization and Cardiovascular Interventions 69:690–696Google Scholar

Abou-Chebl, A, Steinmetz, H (2012). Critique of “Stenting Versus Aggressive Medical Therapy for Intracranial Arterial Stenosis” by Chimowitz et al. in the New England Journal of Medicine. Stroke 43:616–620Google Scholar

Alberts, MJ for the Publications Committee of the WALLSTENT (2001). Results of a multicentre prospective randomised trial of carotid artery stenting vs. carotid endarterectomy. Stroke 32:325Google Scholar

Amarenco, P, Davis, S, Jones, EF et al. (2014). Clopidogrel plus aspirin versus warfarin in patients with stroke and aortic arch plaques. Stroke 45:1248–1257Google Scholar

Bonati, LH, Lyrer, P, Ederle, J et al. (2012). Percutaneous transluminal balloon angioplasty and stenting for carotid artery stenosis. Cochrane Database of Systematic Reviews 9:CD000515Google Scholar

Bonati, LH, Dobson, J, Feathersone, RL et al. (2015). Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: The International Carotid Stenting Study (ICSS) randomized trial. Lancet 385:529–538Google Scholar

Brooks, WH, McClure, RR, Jones, MR et al. (2001). Carotid angioplasty and stenting versus carotid endarterectomy: Randomized trial in a community hospital. Journal of the American College of Cardiologists 38:1589–1595Google Scholar

Brott, TG, Hobson, RW II, Howard, G et al. (2010). Stenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis. New England Journal of Medicine 363:11–23Google Scholar

Brott, TG, Howard, G, Roubin, GS et al. (2016). Long-term results of stenting versus endarterectomy for carotid-artery stenosis. New England Journal of Medicine 374:1021–1031Google Scholar

CAVATAS investigators (2001). Endovascular versus surgical treatment in patients with carotid stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): A randomized trial. Lancet 357:1729–1737CrossRefGoogle Scholar

Chimowitz, MI, Lynn, MJ, Derdeyn, CP et al. (2011). Stenting versus aggressive medical therapy for intracranial arterial stenosis. New England Journal of Medicine 365:993–1003Google Scholar

Compter, A, van der Worp, HB, Schonewille, WJ et al. (2015). Stenting versus medical treatment in patients with symptomatic vertebral artery stenosis: A randomized open-label phase 2 trial. Lancet Neurology 14:606–614Google Scholar

Coward, LJ, Featherstone, RL, Brown, MM (2005). Safety and efficacy of endovascular treatment of carotid artery stenosis compared with carotid endarterectomy: A Cochrane systematic review of the randomized evidence. Stroke 36:905–911Google Scholar

Derdeyn, CP, Grubb, RL Jr., Powers, WJ (2005). Indications for cerebral revascularization for patients with atherosclerotic carotid occlusion. Skull Base 15:7–14Google Scholar

Derdeyn, CP, Chimowitz, MI, Lynn, MJ et al. (2014). Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): The final results of a randomised trial. Lancet 383:333–341Google Scholar

Diaz, FG, Ausman, JI, de los Reyes, RA et al. (1984). Surgical reconstruction of the proximal vertebral artery. Journal of Neurosurgery 61:874–881Google Scholar

Dotter, CT, Judkins, MP, Rosch, J (1967). Nonoperative treatment of arterial occlusive disease: A radiologically facilitated technique. Radiology Clinics of North America 5:531–542Google Scholar

Eberhardt, O, Naegele, T, Raygrotzki, S et al. (2006) Stenting of vertebrobasilar arteries in symptomatic atherosclerotic disease and acute occlusion: Case series and review of the literature. Journal of Vascular Surgery 43:1145–1154Google Scholar

EC–IC Bypass Study Group (1985). Failure of extracranial–intracranial arterial bypass to reduce the risk of ischaemic stroke: Results of an international randomised trial. New England Journal of Medicine 313:1191–1200Google Scholar

Feng, H, Xie, Y, Mei, B et al. (2017). Endovascular vs. medical therapy in symptomatic vertebral artery stenosis: A meta-analysis. Journal of Neurology 264:829–838Google Scholar

Grubb, RL Jr., Powers, WJ, Clarke, WR et al. (2013). Surgical results of the Carotid Occlusion Surgery Study. Journal of Neurosurgery 118:25–33Google Scholar

Hankey, GJ, Warlow, CP (1991). Prognosis of symptomatic carotid artery occlusion. An overview. Cerebrovascular Diseases 1:245–256Google Scholar

Harward, TRS, Wickbom, IG, Otis, SM et al. (1984). Posterior communicating artery visualization in predicting results of carotid endarterectomy for vertebrobasilar insufficiency. American Journal of Surgery 148:43–48Google Scholar

Hopkins, LN, Martin, NA, Hadley, MN et al. (1987). Vertebrobasilar insufficiency. Part 2: microsurgical treatment of intracranial vertebrobasilar disease. Journal of Neurosurgery 66:662–674Google Scholar

International Carotid Stenting Study Investigators (2010). Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): An interim analysis of a randomized controlled trial. Lancet 375:985–997Google Scholar

Karnik, R, Valentin, A, Ammerer, HP et al. (1992). Evaluation of vasomotor reactivity by transcranial Doppler and acetazolamide test before and after extracranial–intracranial bypass in patients with internal carotid artery occlusion. Stroke 23:812–817Google Scholar

Klijn, CJM, Kappelle, LJ, Tulleken, CAF et al. (1997). Symptomatic carotid artery occlusion. A reappraisal of haemodynamic factors. Stroke 28:2084–2093Google Scholar

Latchaw, RE, Ausman, JI, Lee, MC (1979). Superficial temporal–middle cerebral artery bypass. A detailed analysis of multiple pre- and postoperative angiograms in 40 consecutive patients. Journal of Neurosurgery 51:455–465Google Scholar

Malek, AM, Higashida, RT, Phatouros, CC et al. (1999). Treatment of posterior circulation ischaemia with extracranial percutaneous balloon angioplasty and stent placement. Stroke 30:2073–2085Google Scholar

Markus, HS, Larsson, SC, Kuker, W et al. (2017). Stenting for symptomatic vertebral artery stenosis: The Vertebral Artery Ischemia Stenting Trial. Neurology 89:1–8Google Scholar

Mas, JL, Chatellier, G, Beyssen, B for the EVA-3S Investigators (2006). Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. New England Journal of Medicine 355:1660–1671Google Scholar

Mathur, A, Roubin, GS, Iyer, SS et al. (1998). Predictors of stroke complicating carotid artery stenting. Circulation 97:1239–1245Google Scholar

McCabe, DJH, Brown, MM, Clifton, A (1999). Fatal cerebral reperfusion haemorrhage after carotid stenting. Stroke 30:2483–2486Google Scholar

Naylor, AR, Bolia, A, Abbott, RJ et al. (1998). Randomized study of carotid angioplasty and stenting versus carotid endarterectomy: A stopped trial. Journal of Vascular Surgery 28:326–334Google Scholar

Potter, BJ, Pinto, DS (2014). Subclavian steal syndrome. Circulation 129:2320–2323Google Scholar

Powers, WJ, Derdeyn, CP, Fritsch, SM et al. (2000). Benign prognosis of never-symptomatic carotid occlusion. Neurology 54:878–882Google Scholar

Qureshi, AI, Luft, AR, Sharma, M et al. (1999). Frequency and determinants of postprocedural haemodynamic instability after carotid angioplasty and stenting. Stroke 30:2086–2093Google Scholar

Reimers, B, Corvaja, N, Moshiri, S et al. (2001). Cerebral protection with filter devices during carotid artery stenting. Circulation 104:12–15Google Scholar

SPACE Collaborative Group (2006). 30-day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: A randomised non-inferiority trial. Lancet 368:1239–1247Google Scholar

Spetzler, RF, Hadley, MN, Martin, NA et al. (1987). Vertebrobasilar insufficiency. Part 1: Microsurgical treatment of extracranial vertebrobsilar disease. Journal of Neurosurgery 66:648–661CrossRefGoogle ScholarPubMed

Terada, T, Higashida, RT, Halbach, VV et al. (1996). Transluminal angioplasty for arteriosclerotic disease of the distal vertebral and basilar arteries. Journal of Neurology, Neurosurgery and Psychiatry 60:377–381Google Scholar

Thevenet, A, Ruotolo, C (1984). Surgical repair of vertebral artery stenoses. Journal of Cardiovascular Surgery 25:101–110Google Scholar

Warlow, CP (1986). Extracranial to intracranial bypass and the prevention of stroke. Journal of Neurology 233:129–130Google Scholar

Yadav, JS, Wholey, MH, Kuntz, RE et al. (2004). Protected carotid-artery stenting versus endarterectomy in high-risk patients. New England Journal of Medicine 351:1493–1501Google Scholar

Zaidat, OO, Fitzsimmons, BF, Woodward, BK et al. (2015). Effect of a balloon-expandable intracranial stent vs. medical therapy on risk of stroke in patients with symptomatic intracranial stenosis: The VISSIT randomized clinical trial. JAMA 313:1240–1248Google Scholar

Ascher, E, Markevich, N, Hingorani, A et al. (2002). Pseudo-occlusions of the internal carotid artery: A rationale for treatment on the basis of a modified duplex scan protocol. Journal of Vascular Surgery 35:340–350Google Scholar

Barnett, HJM, Taylor, DW, Eliasziw, M for the North American Symptomatic Carotid Endarterectomy Trial Collaborators (1998). Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. New England Journal of Medicine 339:1415–1425Google Scholar

Benade, MM, Warlow, CP (2002). Cost of identifying patients for carotid endarterectomy. Stroke 33:435–439Google Scholar

Bermann, SS, Devine, JJ, Erdos, LS et al. (1995). Distinguishing carotid artery pseudo-occlusion with colour-flow Doppler. Stroke 26:434–438Google Scholar

Blaser, T, Hofmann, K, Buerger, T et al. (2002). Risk of stroke, transient ischaemic attack, and vessel occlusion before endarterectomy in patients with symptomatic severe carotid stenosis. Stroke 33:1057–1062Google Scholar

Boiten, J, Rothwell, PM, Slattery, J for the European Carotid Surgery Trialists’ Collaborative Group (1996). Lacunar stroke in the European Carotid Surgery Trial: Risk factors, distribution of carotid stenosis, effect of surgery and type of recurrent stroke. Cerebrovascular Diseases 6:281–287Google Scholar

Bond, R, Narayan, S, Rothwell, PM et al. (2002). Clinical and radiological risk factors for operative stroke and death in the European Carotid Surgery Trial. European Journal of Vascular Endovascular Surgery 23:108–116Google Scholar

Bond, R, Rerkasem, K, Rothwell, PM (2003). A systematic review of the risks of carotid endarterectomy in relation to the clinical indication and the timing of surgery. Stroke 34:2290–2301Google Scholar

Bond, R, Rerkasem, K, Cuffe, R et al. (2005). A systematic review of the associations between age and sex and the operative risks of carotid endarterectomy. Cerebrovascular Diseases 20:69–77Google Scholar

Eckstein, H, Schumacher, H, Klemm, K et al. (1999). Emergency carotid endarterectomy. Cerebrovascular Diseases 9:270–281Google Scholar

Eliasziw, M, Streifler, JY, Fox, AJ for the North American Symptomatic Carotid Endarterectomy Trial (1994). Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. Stroke 25:304–308Google Scholar

European Carotid Surgery Trialists’ Collaborative Group (1998). Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST). Lancet 351:1379–1387Google Scholar

Fairhead, JF, Rothwell, PM (2005). The need for urgency in identification and treatment of symptomatic carotid stenosis is already established. Cerebrovascular Diseases 19:355–358Google Scholar

Ferguson, GG, Eliasziw, M, Barr, HWK for the North American Symptomatic Carotid Endarterectomy Trial (NASCET) Collaborators (1999). The North American Symptomatic Carotid Endarterectomy Trial: Surgical results in 1415 patients. Stroke 30:1751–1758Google Scholar

Goldstein, LB, McCrory, DC, Landsman, PB et al. (1994). Multicenter review of preoperative risk factors for carotid endarterectomy in patients with ipsilateral symptoms. Stroke 25:1116–1121Google Scholar

Golledge, J, Cuming, R, Beattie, DK et al. (1996). Influence of patient-related variables on the outcome of carotid endarterectomy. Journal of Vascular Surgery 24:120–126Google Scholar

Green, RM, McNamara, J (1987). Optimal resources for carotid endarterectomy. Surgery 102:743–748Google Scholar

Inzitari, D, Eliasziw, M, Gates, P for the North American Symptomatic Carotid Endarterectomy Trial Group (2000). The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. New England Journal of Medicine 342:1693–1700Google Scholar

Johnston, DC, Goldstein, LB (2001). Clinical carotid endarterectomy decision making: Non-invasive vascular imaging versus angiography. Neurology 56: 1009–1015CrossRefGoogle Scholar

Kucey, DS, Bowyer, B, Iron, K et al. (1998). Determinants of outcome after carotid endarterectomy. Journal of Vascular Surgery 28:1051–1058Google Scholar

Lovett, JK, Coull, A, Rothwell, PM on behalf of the Oxford Vascular Study (2004). Early risk of recurrent stroke by aetiological subtype: Implications for stroke prevention. Neurology 62:569–574Google Scholar

MacKinnon, AD, Aaslid, R, Markus, HS (2005). Ambulatory transcranial Doppler cerebral embolic signal detection in symptomatic and asymptomatic carotid stenosis. Stroke 36:1726–1730Google Scholar

Markus, HS, MacKinnon, A (2005). Asymptomatic embolization detected by Doppler ultrasound predicts stroke risk in symptomatic carotid artery stenosis. Stroke 36:971–975Google Scholar

Mayberg, MR, Wilson, E, Yatsu, F for the Veterans Affairs Cooperative Studies Program 309 Trialist Group (1991). Carotid endarterectomy and prevention of cerebral ischaemia in symptomatic carotid stenosis. Journal of the American Medical Association 266:3289–3294CrossRefGoogle ScholarPubMed

McCrory, DC, Goldstein, LB, Samsa, GP et al. (1993). Predicting complications of carotid endarterectomy. Stroke 24:1285–1291Google Scholar

Mead, GE, Lewis, SC, Wardlaw, JM, Dennis, MS, Warlow, CP (2000). Severe ipsilateral carotid stenosis in lacunar ischaemic stroke: Innocent bystanders? Journal of Neurology 249:266–271Google Scholar

Molloy, J, Markus, HS (1999). Asymptomatic embolization predicts stroke and TIA risk in patients with carotid artery stenosis. Stroke 30:1440–1443Google Scholar

Morgenstern, LB, Fox, AJ, Sharpe, BL et al. for the North American Symptomatic Carotid Endarterectomy Trial (NASCET) Group (1997). The risks and benefits of carotid endarterectomy in patients with near occlusion of the carotid artery. Neurology 48:911–915Google Scholar

Morris, S, Patel, NV, Dobson, J et al. (2016). Cost-utility analysis of stenting versus endarterectomy in the International Carotid Stenting Study. International Journal of Stroke 11:446–453Google Scholar

Norris, J, Rothwell, PM (2001). Noninvasive carotid imaging to select patients for endarterectomy: Is it really safer than conventional angiography? Neurology 56:990–991Google Scholar

Pell, JP, Slack, R, Dennis, M et al. (2003). Improvements in carotid endarterectomy in Scotland: Results of a national prospective survey. Scottish Medical Journal 49:53–56Google Scholar

Pritz, MB (1997). Timing of carotid endarterectomy after stroke. Stroke 28:2563–2567Google Scholar

Rantner, B, Pavelka, M, Posch, L, Schmidauer, C, Fraedrich, G (2005). Carotid endarterectomy after ischemic stroke: Is there a justification for delayed surgery? European Journal of Vascular Endovascular Surgery 30:36–40Google Scholar

Riles, TS, Imparato, AM, Jacobowitz, GR et al. (1994). The cause of perioperative stroke after carotid endarterectomy. Journal of Vascular Surgery 19:206–216Google Scholar

Rodgers, H, Oliver, SE, Dobson, R et al. (2000). A regional collaborative audit of the practice and outcome of carotid endarterectomy in the United Kingdom. Northern Regional Carotid Endarterectomy Audit Group. European Journal of Vascular Endovascular Surgery 19:362–369Google Scholar

Rothwell, PM (2004). ACST: Which subgroups will benefit most from carotid endarterectomy? Lancet 364:1122–1123Google Scholar

Rothwell, PM (2005). Risk modelling to identify patients with symptomatic carotid stenosis most at risk of stroke. Neurology Research 27(Suppl 1):S18–S28Google Scholar

Rothwell, PM, Gibson, RJ, Slattery, J et al. (1994). Equivalence of measurements of carotid stenosis: A comparison of three methods on 1001 angiograms. Stroke 25:2435–2439Google Scholar

Rothwell, PM, Slattery, J, Warlow, CP (1996). A systematic comparison of the risk of stroke and death due to carotid endarterectomy for symptomatic and asymptomatic stenosis. Stroke 27:266–269Google Scholar

Rothwell, PM, Slattery, J, Warlow, CP (1997). Clinical and angiographic predictors of stroke and death from carotid endarterectomy: Systematic review. British Medical Journal 315:1571–1577Google Scholar

Rothwell, PM, Warlow, CP on behalf of the European Carotid Surgery Trialists’ Collaborative Group (1999a). Interpretation of operative risks of individual surgeons. Lancet 353:1325Google Scholar

Rothwell, PM, Warlow, CP on behalf of the European Carotid Surgery Trialists’ Collaborative Group (1999b). Prediction of benefit from carotid endarterectomy in individual patients: A risk modelling study. Lancet 353:2105–2110Google Scholar

Rothwell, PM, Warlow, CP on behalf of the European Carotid Surgery Trialists’ Collaborative Group (2000a). Low risk of ischaemic stroke in patients with reduced internal carotid artery lumen diameter distal to severe symptomatic carotid stenosis. Stroke 31:622–630Google Scholar

Rothwell, PM, Gibson, R, Warlow, CP on behalf of the European Carotid Surgery Trialists’ Collaborative Group (2000b). Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischaemic stroke in patients with symptomatic carotid stenosis. Stroke 31:615–621Google Scholar

Rothwell, PM, Pendlebury, ST, Wardlaw, J et al. (2000c). Critical appraisal of the design and reporting of studies of imaging and measurement of carotid stenosis. Stroke 31:1444–1450Google Scholar

Rothwell, PM, Gutnikov, SA, Warlow, CP for the ECST (2003a). Re-analysis of the final results of the European Carotid Surgery Trial. Stroke 34:514–523Google Scholar

Rothwell, PM, Gutnikov, SA, Eliasziw, M et al. for the Carotid Endarterectomy Trialists’ Collaboration (2003b). Pooled analysis of individual patient data from randomised controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 361:107–116Google Scholar

Rothwell, PM, Eliasziw, M, Gutnikov, SA for the Carotid Endarterectomy Trialists Collaboration (2004a). Effect of endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and to the timing of surgery. Lancet 363:915–924Google Scholar

Rothwell, PM, Gutnikov, SA, Eliasziw, M et al. (2004b). Sex difference in effect of time from symptoms to surgery on benefit from endarterectomy for transient ischaemic attack and non-disabling stroke. Stroke 35:2855–2861Google Scholar

Rothwell, PM, Mehta, Z, Howard, SC et al. (2005). From subgroups to individuals: General principles and the example of carotid endartectomy. Lancet 365:256–265Google Scholar

Smurawska, LT, Bowyer, B, Rowed, D et al. (1998). Changing practice and costs of carotid endarterectomy in Toronto, Canada. Stroke 29:2014–2017Google Scholar

Sundt, TM, Sandok, BA, Whisnant, JP (1975). Carotid endarterectomy. Complications and preoperative assessment of risk. Mayo Clinic Proceedings 50:301–306Google Scholar

Terent, A, Marke, LA, Asplund, K et al. (1994). Costs of stroke in Sweden. A national perspective. Stroke 25:2363–2369Google Scholar

Turnbull, RG, Taylor, DC, Hsiang, YN et al. (2000). Assessment of patient waiting times for vascular surgery. Canadian Journal of Surgery 43:105–111Google Scholar

Welsh, S, Mead, G, Chant, H et al. (2004). Early carotid surgery in acute stroke: A multicentre randomized pilot study. Cerebrovascular Disease 18:200–205Google Scholar

Abbott, AL, Paraskevas, KI, Kakkos, SK et al. (2015). Systematic review of guidelines for the management of asymptomatic and symptomatic carotid stenosis. Stroke 46:3288–3301Google Scholar

Akins, CW (1995). The case for concomitant carotid and coronary artery surgery. British Heart Journal 74:97–98Google Scholar

Baker, WH, Howard, VJ, Howard, G et al. (2000). Effect of contralateral occlusion on long-term efficacy of endarterectomy in the asymptomatic carotid atherosclerosis study (ACAS). ACAS Investigators. Stroke 31:2330–2334Google Scholar

Benade, MM, Warlow, CP (2002a). Cost of identifying patients for carotid endarterectomy. Stroke 33:435–439Google Scholar

Benade, MM, Warlow, CP (2002b). Costs and benefits of carotid endarterectomy and associated preoperative arterial imaging: A systematic review of health economic literature. Stroke 33:629–638Google Scholar

Bond, R, Rerkasem, K, Rothwell, PM (2003a). A systematic review of the risks of carotid endarterectomy in relation to the clinical indication and the timing of surgery. Stroke 34:2290–2301Google Scholar

Bond, R, Rerkasem, K, Rothwell, PM (2003b). High morbidity due to endarterectomy for asymptomatic carotid stenosis. Cerebrovascular Diseases 16(Suppl 4):65Google Scholar

Borger, MA, Fremes, SE, Weisel, RD et al. (1999). Coronary bypass and carotid endartertomy: A combined approach increases risk? A meta-analysis. Annals of Thoracic Surgery 68:14–21Google Scholar

Brott, TG, Hobson, RW II, Howard, G et al. (2010). Stenting versus endarterectomy for treatment of carotid-artery stenosis. New England Journal of Medicine 363:11–23Google Scholar

Brott, TG, Howard, G, Roubin, GS et al. (2016). Long-term results of stenting verus endarterectomy for carotid-artery stenosis. New England Journal of Medicine 374:1021–1031Google Scholar

Cuffe, RL, Rothwell, PM (2006). Effect of non-optimal imaging on the relationship between the measured degree of symptomatic carotid stenosis and risk of ischemic stroke. Stroke 37:1785–1791Google Scholar

Davenport, RJ, Dennis, MS, Sandercock, PA et al. (1995). How should a patient presenting with unstable angina and a recent stroke be managed? British Medical Journal 310:1449–1452Google Scholar

den Hartog, AG, Achterberg, S, Moll, FL et al. (2013). Asymptomatic carotid artery stenosis and the risk of ischemic stroke according to subtype in patients with clinical manifest arterial disease. Stroke 44:1002–1007Google Scholar

European Carotid Surgery Trialists’ Collaborative Group (1998). Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST). Lancet 351:1379–1387Google Scholar

Executive Committee for the Asymptomatic Carotid Atherosclerosis Study (1995). Endarterectomy for asymptomatic carotid artery stenosis. Journal of the American Medical Association 273:1421–1428Google Scholar

Graor, RA, Hertzer, NR (1988). Management of coexistent carotid artery and coronary artery disease. Stroke 19:1441–1443Google Scholar

Gupta, A, Baradaran, H, Schweitzer, AD et al. (2013). Carotid plaque MRI and stroke risk: A systematic review and meta-analysis. Stroke 44:3071–3077Google Scholar

Gupta, A, Kesavabhotla, K, Baradaran, H et al. (2015). Plaque echolucency and stroke risk in asymptomatic carotid stenosis: A systematic review and meta-analysis. Stroke 46:91–97Google Scholar

Halliday, AW, Thomas, D, Mansfield, A (1994). The Asymptomatic Carotid Surgery Trial (ACST). Rationale and design. Steering Committee. European Journal of Vascular Surgery 8:703–710Google Scholar

Halliday, A, Mansfield, A, Marro, J et al. (2004). Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: Randomised controlled trial. Lancet 363:1491–1502Google Scholar

Halliday, A, Harrison, M, Hayter, E et al. (2010). 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): A multicenter randomized trial. Lancet 376:1074–1084Google Scholar

Hertzer, NR, Loop, FD, Beven, EG et al. (1989). Surgical staging for simultaneous coronary and carotid disease: A study including prospective randomisation. Journal of Vascular Surgery 9:455–463Google Scholar

Kresowik, TF, Bratzler, DW, Kresowik, RA et al. (2004). Multistate improvement in process and outcomes of carotid endarterectomy. Journal of Vascular Surgery 39:372–380Google Scholar

Markus, HS, MacKinnon, A (2005). Asymptomatic embolization detected by Doppler ultrasound predicts stroke risk in symptomatic carotid artery stenosis. Stroke 36:971–975Google Scholar

Markus, HS, King, A, Shipley, M et al. (2010). Asymptomatic embolization for prediction of stroke in the Asymptomatic Carotid Emboli Study (ACES): A prospective observational study. Lancet Neurology 9:663–671Google Scholar

Marquardt, L, Geraghty, OC, Mehta, Z et al. (2010). Low risk of ipsilateral stroke in patients with asymptomatic carotid stenosis on best medical treatment: A prospective, population-based study. Stroke 41:e11–e17Google Scholar

Moore, WS, Young, B, Baker, WH et al. (1996). Surgical results: A justification of the surgeon selection process for the ACAS trial. The ACAS Investigators. Journal of Vascular Surgery 23:323–328Google Scholar

Naylor, AR (2004). A critical review of the role of carotid disease and the outcomes of staged and synchronous carotid surgery. Seminars in Cardiothoracic Vascular Anesthesia 8:37–42Google Scholar

Naylor, AR, Mehta, Z, Rothwell, PM et al. (2002). Carotid artery disease and stroke during coronary artery bypass: A critical review of the literature. European Journal of Vascular Endovascular Surgery 23:283–294Google Scholar

Naylor, AR, Cuffe, RL, Rothwell, PM et al. (2003). A systematic review of outcomes following staged and synchronous carotid endarterectomy and coronary artery bypass. European Journal of Vascular Endovascular Surgery 25:380–389Google Scholar

Nicolaides, AN, Kakkos, SK, Griffin, M et al. (2005). Severity of asymptomatic carotid stenosis and risk of ipsilateral hemispheric ischaemic events: Results from the ACSRS study. European Journal of Vascular Endovascular Surgery 30:275–284Google Scholar

Redgrave, JN, Lovett, JK, Gallagher, PJ et al. (2006). Histological assessment of 526 symptomatic carotid plaques in relation to the nature and timing of ischemic symptoms: The Oxford plaque study. Circulation 113:2320–2328Google Scholar

Rothwell, PM (2004). ACST: Which subgroups will benefit most from carotid endarterectomy? Lancet 364:1122–1123Google Scholar

Rothwell, PM, Slattery, J, Warlow, CP (1996). A systematic review of the risk of stroke and death due to carotid endarterectomy. Stroke 27:260–265Google Scholar

Rothwell, PM, Warlow, CP on behalf of the European Carotid Surgery Trialists’ Collaborative Group (2000). Low risk of ischaemic stroke in patients with reduced internal carotid artery lumen diameter distal to severe symptomatic carotid stenosis. Stroke 31:622–630Google Scholar

Rothwell, PM, Gutnikov, SA, Eliasziw, M for the Carotid Endarterectomy Trialists’ Collaboration (2003). Pooled analysis of individual patient data from randomised controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 361:107–116Google Scholar

Rothwell, PM, Eliasziw, M, Gutnikov, SA et al. for the Carotid Endarterectomy Trialists Collaboration (2004). Effect of endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and to the timing of surgery. Lancet 363:915–924Google Scholar

Spence, JD, Tamayo, A, Lownie, SP et al. (2005). Absence of microemboli on transcranial Doppler identifies low-risk patients with asymptomatic carotid stenosis. Stroke 36:2373–2378Google Scholar

Tang, T, Howarth, SP, Miller, SR et al. (2006). Assessment of inflammatory burden contralateral to the symptomatic carotid stenosis using high-resolution ultrasmall, superparamagnetic iron oxide-enhanced MRI. Stroke 37:2266–2270Google Scholar

Trivedi, RA, King-Im, JM, Graves, MJ et al. (2004). In vivo detection of macrophages in human carotid atheroma: Temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke 35:1631–1635Google Scholar

van der Wal, AC, Becker, AE, van der Loos, CM et al. (1994). Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 89:36–44Google Scholar