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Chapter 8 - Anxiety and Cognitive Functioning

Published online by Cambridge University Press:  08 March 2021

By
Sherry A. Beaudreau ,
Andrew J. Petkus ,
Nathan C. Hantke  and
Christine E. Gould
Edited by
Gerard J. Byrne  and
Nancy A. Pachana
Gerard J. Byrne
Affiliation:
University of Queensland
Nancy A. Pachana
Affiliation:
University of Queensland
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Summary

The past decade has witnessed a proliferation of studies examining anxiety in older populations. This research underscores how anxiety is not just an ancillary symptom of depression, but a clinical issue on its own. Not only does anxiety cause suffering in older adults, but anxious older adults also have more functional disability (Brenes et al., 2005) and a reduced quality of life (Wetherell et al., 2004) compared to non-anxious older adults. In conditions that are common in later life (i.e., poor physical health, depression), those older adults experiencing comorbid anxiety typically have greater disability compared to non-anxious adults with these conditions. Cognitive functioning and the presence of neurocognitive disorders are aspects of comorbidity that have garnered increasing research attention (Beaudreau & O’Hara, 2008). This exciting new research underscores the complexity of the relations between anxiety and cognitive functioning in older individuals.

Type
Chapter
Information
Anxiety in Older People
Clinical and Research Perspectives
 , pp. 117 - 138
Publisher: Cambridge University Press
Print publication year: 2021

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References

Aarsland, D., Zaccai, J. and Brayne, C. (2005). A systematic review of prevalence studies of dementia in Parkinson’s disease. Official Journal of the Movement Disorders Society, 20(10), 1255–1263.CrossRefGoogle ScholarPubMed
Aleopoulous, G. S., Raue, P. and Areán, P.A. (2003). Problem-solving therapy versus supportive therapy in geriatric major depression with executive dysfunction. American Journal of Geriatric Psychiatry, 11, 46–52.Google Scholar
Alexopoulos, G. S., Raue, P. J., Kiosses, D. N., et al. (2011). Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disability. Archives of General Psychiatry, 68, 33–41.Google Scholar
American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Washington, DC: American Psychiatric Association.Google Scholar
Andreescu, C., Teverovsky, E., Fu, B., Hughes, T. F., Chang, C. C. and Ganguli, M. (2014). Old worries and new anxieties: behavioral symptoms and mild cognitive impairment in a population study. American Journal of Geriatric Psychiatry, 22(3), 274–284.Google Scholar
Areán, P. A., Raue, P., Mackin, R. S., Kanellopoulos, D., McCulloch, C. and Alexopoulos, G. S. (2010). Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. American Journal of Geriatric Psychiatry, 167, 1391–1398.Google Scholar
Ayers, C. R., Saxena, S., Espejo, E., Twamley, E. W., Granholm, E. and Wetherell, J. L. (2014). Novel treatment for geriatric hoarding disorder: an open trial of cognitive rehabilitation paired with behavior therapy. American Journal of Geriatric Psychiatry, 22(3), 248–252.CrossRefGoogle ScholarPubMed
Barnes, L. L., Wilson, R. S., Everson-Rose, S. A., Hayward, M. D., Evans, D. A. and Mendes de Leon, C. F. (2012). Effects of early-life adversity on cognitive decline in older African Americans and whites. Neurology, 79(24), 2321–2327.Google Scholar
Beaudreau, S. A. and O’Hara, R. (2008). Late-life anxiety and cognitive impairment: a review. American Journal of Geriatric Psychiatry, 16(10), 790–803.Google Scholar
Beaudreau, S. A. and O’Hara, R. (2009). The association of anxiety and depressive symptoms with cognitive performance in community-dwelling older adults. Psychology and Aging, 24(2), 507–512.Google Scholar
Beaudreau, S. A., Gould, C. E., Fairchild, J. K., Rideaux, T., Huh, J. and O’Hara, R. (2014). A pilot comparison of problem solving therapy and cognitive behavioral therapy for generalized anxiety disorder in older adults. Symposium conducted at the meeting of the Gerontological Society of America, Washington, DC.Google Scholar
Beaudreau, S. A., Hantke, N. C., Mashal, N., Gould, C. E., Henderson, V. W. and O’Hara, R. (2017). Unlocking neurocognitive substrates of late-life affective symptoms using the Research Domain Criteria: worry is an essential dimension. Frontiers in Aging Neuroscience, 9, 380.Google Scholar
Beaudreau, S. A., MacKay-Brant, A. and Reynolds, J. (2013). Application of a cognitive neuroscience perspective of cognitive control to late life anxiety. Journal of Anxiety Disorders, 27(6), 559–566.Google Scholar
Beaudreau, S. A., Rideaux, T., O’Hara, R. and Arean, P. (2015). Does cognition predict treatment response and remission in psychotherapy for late-life depression? American Journal of Geriatric Psychiatry, 23(2), 215–219.Google Scholar
Bellander, M., Backman, L., Liu, T., et al. (2015). Lower baseline performance but greater plasticity of working memory for carriers of the Val allele of the COMT Val(1)(5)(8)Met polymorphism. Neuropsychology, 29, 247–254.Google Scholar
Borkovec, T. D., Robinson, E., Pruzinsky, T., and DePree, J. A. (1983). Preliminary exploration of worry: some characteristics and processes. Behaviour Research and Therapy, 21, 9–16.Google Scholar
Bower, E. S., Wetherell, J. L., Mon, T. and Lenze, E. J. (2015). Treating anxiety disorders in older adults: current treatments and future directions. Harvard Review of Psychiatry, 23(5), 329–342.Google Scholar
Brandt, F., Thvilum, M., Almind, D., et al. (2014). Hyperthyroidism and psychiatric morbidity: evidence from a Danish nationwide register study. European Journal of Endocrinology/European Federation of the Endocrinological Society, 170, 341–348.Google Scholar
Brenes, G. A., Guralnik, J. M., Williamson, J. D., Fried, L. P., Simpson, C. and Penninx, B. W. (2005). The influence of anxiety on the progression of disability. Journal of the American Geriatrics Society, 53(1), 34–39.Google Scholar
Brodaty, H., Connors, M. H., Xu, J., Woodward, M. and Ames, D. (2015). The course of neuropsychiatric symptoms in dementia: a 3-year longitudinal study. Journal of the American Medical Directors Association, 16(5), 380–387.Google Scholar
Brown, T. A. and Barlow, D. H. (2009). A proposal for a dimensional classification system based on the shared features of the DSM-IV anxiety and mood disorders: implications for assessment and treatment. Psychological Assessment, 21(3), 256–271.Google Scholar
Burton, C., Campbell, P., Jordan, K., Strauss, V. and Mallen, C. (2013). The association of anxiety and depression with future dementia diagnosis: a case–control study in primary care. Family Practice, 30(1), 25–30.CrossRefGoogle ScholarPubMed
Butters, M. A., Bhalla, R. K., Andreescu, C., et al. (2011). Changes in neuropsychological functioning following treatment for late-life generalised anxiety disorder. British Journal of Psychiatry, 199(3), 211–218.Google Scholar
Cardenas, V. A., Samuelson, K., Lenoci, M., et al. (2011). Changes in brain anatomy during the course of posttraumatic stress disorder. Psychiatry Research: Neuroimaging, 193(2), 93–100.Google Scholar
Carlson, N. (2004). Physiology of behavior, 8th ed. New York: Pearson.Google ScholarPubMed
Carmichael, O. (2014). Preventing vascular effects on brain injury and cognition late in life: knowns and unknowns. Neuropsychology Review, 24(3), 371–387.Google Scholar
Caspi, A., Hariri, A. R., Holmes, A., Uher, R. and Moffitt, T. E. (2010). Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509–527.Google Scholar
Coles, M. E. and Heimberg, R. G. (2002). Memory biases in the anxiety disorders: current status. Clinical Psychology Review, 22(4), 587–627.CrossRefGoogle ScholarPubMed
Corbo, V., Clement, M. H., Armony, J. L., Pruessner, J. C. and Brunet, A. (2005). Size versus shape differences: contrasting voxel-based and volumetric analyses of the anterior cingulate cortex in individuals with acute posttraumatic stress disorder. Biological Psychiatry, 58(2), 119–124.Google Scholar
Cummings, J. L. (1997). The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology, 48(5), 10S–16S.Google Scholar
Dannlowski, U., Stuhrmann, A., Beutelmann, V., et al. (2012). Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. Biological Psychiatry, 71(4), 286–293.Google Scholar
DeLuca, A. K., Lenze, E. J., Mulsant, B. H., et al. (2005). Comorbid anxiety disorder in late life depression: association with memory decline over four years. International Journal of Geriatric Psychiatry, 20(9), 848–854.Google Scholar
Dissanayaka, N. N., Sellbach, A., Matheson, S., et al. (2010). Anxiety disorders in Parkinson’s disease: prevalence and risk factors. Official Journal of the Movement Disorder Society, 25(7), 838–845.CrossRefGoogle ScholarPubMed
Domschke, K., Deckert, J., O’Donovan, M. C. and Glatt, S. J. (2007). Meta-analysis of COMT Val158Met in panic disorder: Ethnic heterogeneity and gender specificity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144B, 667–673.Google Scholar
Drag, L. L. and Bieliauskas, L. A. (2010). Contemporary review 2009: cognitive aging. Journal of Geriatric Psychiatry and Neurology, 23(2), 75–93.Google Scholar
Eysenck, M. W., Derakshan, N., Santos, R. and Calvo, M. G. (2007). Anxiety and cognitive performance: Attentional Control Theory. Emotion, 7(2), 336–353.Google Scholar
Feeney, J., Kamiya, Y., Robertson, I. H. and Kenny, R. A. (2013). Cognitive function is preserved in older adults with a reported history of childhood sexual abuse. Journal of Traumatic Stress, 26(6), 735–743.CrossRefGoogle ScholarPubMed
Ferretti, L., McCurry, S. M., Logsdon, R., Gibbons, L. and Teri, L. (2001). Anxiety and Alzheimer’s disease. Journal of Geriatric Psychiatry and Neurology, 14(1), 52–58.Google Scholar
Franz, C. E., O’Brien, R. C., Hauger, R. L., et al. (2011). Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: the Vietnam Era Twin Study of Aging. Psychoneuroendocrinology, 36(7), 1040–1052.Google Scholar
Gallacher, J., Bayer, A., Fish, M., et al. (2009). Does anxiety affect risk of dementia? Findings from the Caerphilly Prospective Study. Psychosomatic Medicine, 71(6), 659–666.Google Scholar
Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., et al. (2009). Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Molecular Psychiatry, 14(7), 681–695.CrossRefGoogle ScholarPubMed
Geda, Y. E., Roberts, R. O., Knopman, D. S., et al. (2008). Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study. Archives of General Psychiatry, 65(10), 1193–1198.Google Scholar
Gellis, Z. D. and Bruce, M. L. (2010). Problem solving therapy for subthreshold depression in home healthcare patients with cardiovascular disease. American Journal of Geriatric Psychiatry, 18, 464–474.Google Scholar
Gennatas, E. D., Cholfin, J. A., Zhou, J., et al. (2012). COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures. Neurology, 78, 1663–1669.Google Scholar
Goldin, P. R. and Gross, J. J. (2010). Effects of mindfulness-based stress reduction (MBSR) on emotion regulation in social anxiety disorder. Emotion, 10(1), 83–91.Google Scholar
Gonçalves, D. C. and Byrne, G. J. (2012). Interventions for generalized anxiety disorder in older adults: systematic review and meta-analysis. Journal of Anxiety Disorders, 26(1), 1–11.Google Scholar
Gould, R. L., Coulson, M. C. and Howard, R. J. (2012). Efficacy of cognitive behavioral therapy for anxiety disorders in older people: a meta-analysis and meta-regression of randomized controlled trials. Journal of American Geriatrics Society, 60(2), 218–229.Google Scholar
Gould, C. E., Segal, D. L., Yochim, B. P., Pachana, N.A., Byrne, G. J. and Beaudreau, S. A. (2014). Measuring anxiety in late life: a psychometric examination of the Geriatric Anxiety Inventory and Geriatric Anxiety Scale. Journal of Anxiety Disorders, 28(8), 804–811.Google Scholar
Gulseren, S., Gulseren, L., Hekimsoy, Z., Cetinay, P. and Tokatlioglu, B. (2006). Depression, anxiety, health-related quality of life, and disability in patients with overt and subclinical thyroid dysfunction. Archives of Medical Research, 37(1), 133–139.Google Scholar
Heim, C. and Nemeroff, C. B. (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biological Psychiatry, 49(12), 1023–1039.Google Scholar
Hogan, M. J. (2003). Divided attention in older but not younger adults is impaired by anxiety. Experimental Aging Research, 29(2), 111–136.Google Scholar
Hsu, K. J., Young-Wolff, K. C., Kendler, K. S., Halberstadt, L. J. and Prescott, C. A. (2014). Neuropsychological deficits in major depression reflect genetic/familial risk more than clinical history: a monozygotic discordant twin-pair study. Psychiatry Research, 215(1), 87–94.CrossRefGoogle ScholarPubMed
Hwang, T. J., Masterman, D. L., Ortiz, F., Fairbanks, L. A. and Cummings, J. L. (2004). Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alzheimer Disease and Associated Disorders, 18(1), 17–21.Google Scholar
Insel, T. R. (2014). The NIMH Research Domain Criteria (RDoC) Project: precision medicine for psychiatry. American Journal of Psychiatry, 171(4), 395–397.Google Scholar
Jaspar, M., Dideberg, V., Bours, V., Maquet, P. and Collette, F. (2015). Modulating effect of COMT Val(158)Met polymorphism on interference resolution during a working memory task. Brain and Cognition, 95, 7–18.Google Scholar
Kabat-Zinn, J., Massion, A. O., Kristeller, J., et al. (1992). Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders. American Journal of Psychiatry, 149(7), 936–943.Google Scholar
Karttunen, K., Karppi, P., Hiltunen, A., et al. (2011). Neuropsychiatric symptoms and quality of life in patients with very mild and mild Alzheimer’s disease. International Journal of Geriatric Psychiatry, 26(5), 473–482.CrossRefGoogle ScholarPubMed
Kaszniak, A. W. and Christenson, G. D. (1994). Differential diagnosis of dementia and depression. In Storandt, M and VandenBos, G. R., eds., Neuropsychological Assessment of Dementia and Depression in Older Adults: A Clinician’s Guide. Washington, DC: American Psychological Association, pp. 81–119.Google Scholar
Kendler, K. S., Heath, A. C., Martin, N. G. and Eaves, L. J. (1987). Symptoms of anxiety and symptoms of depression. Same genes, different environments? Archives of General Psychiatry, 44(5), 451–457.Google Scholar
Klauke, B., Deckert, J., Reif, A., et al. (2011). Serotonin transporter gene and childhood trauma – a G × E effect on anxiety sensitivity. Depression and Anxiety, 28, 1048–1057.Google Scholar
Kremen, W. S., O’Brien, R. C., Panizzon, M. S., et al. (2010). Salivary cortisol and prefrontal cortical thickness in middle-aged men: a twin study. Neuroimage, 53(3), 1093–1102.Google Scholar
Lee, L. O. and Knight, B. G. (2009). Attentional bias for threat in older adults: moderation of the positivity bias by trait anxiety and stimulus modality. Psychological Aging, 24, 741–747.Google Scholar
Lenze, E. J., Dixon, D., Mantella, R. C., et al. (2012). Treatment-related alteration of cortisol predicts change in neuropsychological function during acute treatment of late-life anxiety disorder. International Journal of Geriatric Psychiatry, 27(5), 454–462.Google Scholar
Lenze, E. J., Dixon, D., Nowotny, P., et al. (2013). Escitalopram reduces attentional performance in anxious older adults with high-expression genetic variants at serotonin 2 A and 1B receptors. International Journal of Neuropsychopharmacology, 16(2), 279–288.Google Scholar
Lenze, E. J., Hickman, S., Hershey, T., et al. (2014). Mindfulness-based stress reduction for older adults with worry symptoms and co-occurring cognitive dysfunction. International Journal of Geriatric Psychiatry, 29(10), 991–1000.Google Scholar
Lenze, E. J., Mantella, R. C., Shi, P., et al. (2011). Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram. American Journal of Geriatric Psychiatry, 19(5), 482–490.Google Scholar
Levine, M. E., Cole, S. W., Weir, D. R. and Crimmins, E. M. (2015). Childhood and later life stressors and increased inflammatory gene expression at older ages. Social Science & Medicine, 130, 16–22.Google Scholar
Li, S., Wang, C., Wang, W., Dong, H., Hou, P. and Tang, Y. (2008). Chronic mild stress impairs cognition in mice: from brain homeostasis to behavior. Life Science, 82(17–18), 934–942.Google Scholar
Lillevang-Johansen, M., Petersen, I., Christensen, K., Hegedüs, L. and Brix, T. H. (2014). Is previous hyperthyroidism associated with long-term cognitive dysfunction? A twin study. Clinical Endocrinology (Oxford), 80(2), 290–295.CrossRefGoogle ScholarPubMed
Lupien, S. J., de Leon, M., de Santi, S., et al. (1998). Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nature Neuroscience, 1(1), 69–73.Google Scholar
Lyketsos, C. G., Lopez, O., Jones, B., Fitzpatrick, A. L., Breitner, J. and DeKosky, S. (2002). Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. Journal of the American Medical Association, 288(12), 1475–1483.Google Scholar
Lyketsos, C. G., Steinberg, M., Tschanz, J. T., et al. (2000). Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging, American Journal of Psychiatry, 157(5), 708–714.Google Scholar
Lyons, D. M. and Macri, S. (2011). Resilience and adaptive aspects of stress in neurobehavioral development. Neuroscience and Biobehavioral Reviews, 35(7), 1451.Google Scholar
Mah, L., Binns, M. A., Steffens, D. C. (2015). Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease. American Journal of Geriatric Psychiatry, 23(5), 466–476.Google Scholar
Majer, M., Nater, U. M., Lin, J. M., Capuron, L. and Reeves, W. C. (2010). Association of childhood trauma with cognitive function in healthy adults: a pilot study. BMC Neurology, 10, 61.Google Scholar
Mantella, R. C., Butters, M. A., Amico, J. A., et al. (2008). Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorder. Psychoneuroendocrinology, 33(6), 773–781.Google Scholar
Mantella, R. C., Butters, M. A., Dew, M. A., et al. (2007). Cognitive impairment in late-life generalized anxiety disorder. American Journal of Geriatric Psychiatry, 15(8), 673–679.Google Scholar
Marchant, N. L. and Howard, R. J. (2015). Cognitive debt and Alzheimer’s disease. Journal of Alzheimer’s Disease, 44(3), 755–770.Google Scholar
Mathews, A. (1990). Why worry? The cognitive function of anxiety. Behaviour Research Therapy, 28(6), 455–468.Google Scholar
McGrath, M., Kawachi, I., Ascherio, A., Colditz, G. A., Hunter, D. J. and De Vivo, I. (2004). Association between catechol-O-methyltransferase and phobic anxiety. American Journal of Psychiatry, 161, 1703–1705.CrossRefGoogle ScholarPubMed
Michaelson, D. M. (2014). APOE ε4: the most prevalent yet understudied risk factor for Alzheimer’s disease. Alzheimer’s & Dementia, 10(6), 861–868.Google Scholar
Micheli, D., Bonvicini, C., Rocchi, A., et al. (2006). No evidence for allelic association of serotonin 2 A receptor and transporter gene polymorphisms with depression in Alzheimer disease. Journal of Alzheimer’s Disease, 10, 371–378.Google Scholar
Michels, A., Multhammer, M., Zintl, M., Mendoza, M. C. and Klunemann, H. H. (2012). Association of apolipoprotein E epsilon4 (APOE epsilon4) homozygosity with psychiatric behavioral symptoms. Journal of Alzheimer’s Disease, 28(1), 25–32.Google Scholar
Mikami, K., Jorge, R. E., Moser, D. J., et al. (2014). Prevention of post-stroke generalized anxiety disorder, using escitalopram or problem-solving therapy. Journal of Neuropsychiatry and Clinical Neurosciences, 26, 323–328.CrossRefGoogle ScholarPubMed
Mohlman, J., Price, R. B., Eldreth, D. A., Chazin, D., Glover, D. M. and Kates, W. R. (2009). The relation of worry to prefrontal cortex volume in older adults with and without generalized anxiety disorder. Psychiatry Research, 173(2), 121–127.Google Scholar
Mozaffarian, D., Benjamin, E. J., Go, A. S., et al. (2015). Heart disease and stroke statistics – 2015 update: a report from the American Heart Association. Circulation, 131(4), e29–e322.Google Scholar
Nation, D. A., Edmonds, E. C., Bangen, K. J., et al. (2015). Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults. JAMA Neurolology, 72(5), 546–553.Google Scholar
Nezu, A. M., Nezu, C. M. and D’ Zurilla, T. J. (2013). Problem-Solving Therapy: A Treatment Manual. New York: Springer Publishing Company.Google Scholar
Nuss, P. (2015). Anxiety disorders and GABA neurotransmission: a disturbance of modulation. Neuropsychiatric Disease and Treatment, 11, 165–175.Google ScholarPubMed
Palmer, K., Berger, A. K., Monastero, R., Winblad, B., Bäckman, L. and Fratiglioni, L. (2007). Predictors of progression from mild cognitive impairment to Alzheimer disease. Neurology, 68(19), 1596–1602.Google Scholar
Papenberg, G., Lovden, M., Laukka, E. J., et al. (2015). Magnified effects of the COMT gene on white-matter microstructure in very old age. Brain Structure and Function, 220, 2927–2938.Google Scholar
Paukert, A. L., Kraus-Schuman, C., Wilson, N., et al. (2013). The peaceful mind manual: A protocol for treating anxiety in persons with dementia. Behavior Modification, 37(5), 631–664.Google Scholar
Petkus, A. J. (2014). Anxiety and Cognition in Swedish Twins: Genetic and Environmental Contributions. Doctoral dissertation, University of California, San Diego.Google Scholar
Petkus, A. J., Gatz, M., Reynolds, C. A., Kremen, W. S. and Wetherell, J. L. (2016a). Stability of genetic and environmental contributions to anxiety symptoms in older adulthood. Behavior Genetics, 46(4), 492–505.Google Scholar
Petkus, A. J., Lenze, E. J., Butters, M. A., Twamley, E. W. and Wetherell, J. L. (2018). Childhood trauma is associated with poorer cognitive performance in older adults. Journal of Clinical Psychiatry, 79(1), 16m11021.Google Scholar
Petkus, A. J., Reynolds, C., Wetherell, J. L., Kremen, W. S., Pedersen, N. and Gatz, M. (2016b). Anxiety is associated with increased risk of dementia in older Swedish twins. 12(4), 399–406.Google Scholar
Petkus, A. J., Wetherell, J. L., Stein, M. B., Liu, L. and Barrett-Connor, E. (2012). History of sexual assault is associated with greater declines in executive functioning in older adults with APOE epsilon4. Journal of Gerontology: Series B: Psychology Sciences and Social Sciences, 67(6), 653–659.Google Scholar
Pietrzak, R. H., Lim, Y. Y., Neumeister, A., et al. (2015). Amyloid-beta, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study. JAMA Psychiatry, 72(3), 284–291.Google Scholar
Pietrzak, R. H., Maruff, P., Woodward, M., et al. (2012). “Mild worry symptoms predict decline in learning and memory in healthy older adults: a 2-year prospective cohort study”: erratum. American Journal of Geriatric Psychiatry, 20(7), 634.Google Scholar
Potvin, O., Forget, H., Grenier, S., Préville, M. and Hudon, C. (2011). Anxiety, depression, and 1-year incident cognitive impairment in community-dwelling older adults. Journal of American Geriatrics Society, 59(8), 1421–1428.Google Scholar
Price, R. B., Eldreth, D. A. and Mohlman, J. (2011). Deficient prefrontal attentional control in late-life generalized anxiety disorder: an fMRI investigation. Translational Psychiatry, 1, e46.Google Scholar
Proitsi, P., Lupton, M. K., Reeves, S. J., et al. (2012). Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. Neurobiology of Aging, 33(4), 791–803.Google Scholar
Radua, J., van den Heuvel, O. A., Surguladze, S. and Mataix-Cols, D. (2010). Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders. Archives of General Psychiatry, 67(7), 701–711.CrossRefGoogle ScholarPubMed
Reynolds, C. A., Jansson, M., Gatz, M. and Pedersen, N. L. (2006). Longitudinal change in memory performance associated with HTR2A polymorphism. Neurobiology of Aging, 27(1), 150–154.Google Scholar
Ritchie, M. and Yeap, B. B. (2015). Thyroid hormone: influences on mood and cognition in adults. Maturitas, 81(2), 266–275.Google Scholar
Rodrigues, R., Petersen, R. B. and Perry, G. (2014). Parallels between major depressive disorder and Alzheimer’s disease: role of oxidative stress and genetic vulnerability. Cellular and Molecular Neurobiology, 34(7), 925–949.Google Scholar
Salthouse, T. A. (1996). The processing-speed theory of adult age differences in cognition. Psychological Review, 103(3), 403–428.Google Scholar
Schultz, S. K., Moser, D. J., Bishop, J. R. and Ellingrod, V. L. (2005). Phobic anxiety in late-life in relationship to cognition and 5HTTLPR polymorphism. Psychiatric Genetics, 15(4), 305–306.Google Scholar
Seignourel, P. J., Kunik, M. E., Snow, L., Wilson, N. and Stanley, M. (2008). Anxiety in dementia: a critical review. Clinical Psychology Review, 28, 1071–1082.Google Scholar
Sinoff, G. and Werner, P. (2003). Anxiety disorder and accompanying subjective memory loss in the elderly as a predictor of future cognitive decline. International Journal of Geriatric Psychiatry, 18(10), 951–959.Google Scholar
Stanley, M. A., Calleo, J., Bush, A. L., et al. (2013). The Peaceful Mind program: a pilot test of a cognitive–behavioral therapy-based intervention for anxious patients with dementia. American Journal of Geriatric Psychiatry, 21(7), 696–708.Google Scholar
Stein, M. B., Koverola, C., Hanna, C., Torchia, M. G. and McClarty, B. (1997). Hippocampal volume in women victimized by childhood sexual abuse. Psychological Medicine, 27(4), 951–959.Google Scholar
Stern, Y. (2002). What is cognitive reserve? Theory and research application of the reserve concept. Journal of the International Neuropsychological Society, 8(3), 448–460.Google Scholar
Suliman, S., Hemmings, S. J. and Seedat, S. (2013). Brain-derived neurotrophic factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis. Frontiers in Integrative Neuroscience, 7, 55.Google Scholar
Suri, D., Veenit, V., Sarkar, A., et al. (2013). Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, BDNF expression, and cognition. Biological Psychiatry, 73(7), 658–666.Google Scholar
Tatsch, M. F., Bottino, C. M., Azevedo, D., et al. (2006). Neuropsychiatric symptoms in Alzheimer disease and cognitively impaired, nondemented elderly from a community-based sample in Brazil: prevalence and relationship with dementia severity. American Journal of Geriatric Psychiatry, 14(5), 438–445.Google Scholar
Teri, L., Ferretti, L. E., Gibbons, L. E., et al. (1999). Anxiety of Alzheimer’s disease: prevalence, and comorbidity. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 54(7), M348–M352.CrossRefGoogle ScholarPubMed
Vøllestad, J., Sivertsen, B. and Nielsen, G. H. (2011). Mindfulness-based stress reduction for patients with anxiety disorders: evaluation in a randomized controlled trial. Behaviour Research and Therapy, 49, 281–288.Google Scholar
Ward, D. D., Summers, M. J., Saunders, N. L., Janssen, P., Stuart, K. E. and Vickers, J. C. (2014). APOE and BDNF Val66Met polymorphisms combine to influence episodic memory function in older adults. Behavioural Brain Research, 271, 309–315.Google Scholar
Wetherell, J. L., Reynolds, C. A., Gatz, M. and Pedersen, N. L. (2002). Anxiety, cognitive performance, and cognitive decline in normal aging. Journals of Gerontology. Series B: Psychological Sciences and Social Sciences, 57B(3), P246–P255.Google Scholar
Wetherell, J. L., Thorp, S. R., Patterson, T. L., Golshan, S., Jeste, D. V. and Gatz, M. (2004). Quality of life in geriatric generalized anxiety disorder: a preliminary investigation. Journal of Psychiatric Research, 38(3), 305–312.Google Scholar
Wu, Z., Guo, Z., Gearing, M. and Chen, G. (2014). Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model. Nature Communications, 5, 4159.Google Scholar
Yochim, B. P., Mueller, A. E. and Segal, D. L. (2013). Late life anxiety is associated with decreased memory and executive functioning in community dwelling older adults. Journal of Anxiety Disorders, 27(6), 567–575.Google Scholar
Yudiatro, F. L., Muliadi, L., Moeljanto, D. and Hartono, B. (2006). Neuropsychological findings in hyperthyroid patients. Acta Medica Indonesiana, 38(1), 6–10.Google Scholar

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