There are many challenges of proper drug dosing with nanodelivery systems. The first part of this discussion concerns how experts think about drug dosing with conventional drugs. In the second part, we need to consider the differences between nanodevices and traditional drug delivery, and pharmacokinetics using nanodrug delivery. Drug dosing uses scale-up methods from animal model data before testing on humans. New organ-on-a-chip and human-on-a-chip technologies may someday replace animal data.