Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-8bljj Total loading time: 0 Render date: 2024-06-27T10:03:17.306Z Has data issue: false hasContentIssue false

Debate 44B - What is the Best Management Option for Young Women with Stage IB2 Cervical Cancer Who Wish to Preserve Fertility?

Neo-adjuvant Chemotherapy Followed by Fertility-sparing Surgery

from Section V - Cervical Cancer

Published online by Cambridge University Press:  20 July 2023

Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
Get access

Summary

The radical trachelectomy procedure is now recognized as a “standard of care” option for young women with early-stage cervical cancer who wish to preserve fertility. However, the oncologic safety of this approach has mostly been validated for small lesions measuring <2 cm. The optimal management for patients with larger lesions who wish to preserve fertility remains unsettled and there is currently no standard of care. There are essentially two alternatives: either to proceed with upfront radical trachelectomy or neo-adjuvant chemotherapy (NACT) followed by fertility-sparing surgery (FSS). The balance between oncologic outcomes and surgical morbidity versus fertility and obstetrical outcomes need to be carefully balanced and addressed. We wish to present to the readers with arguments for and against both options in the hopes that it will help clinicians decide which is the best option for their individual patients.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Fokom Domgue, J, et al. Conservative management of cervical cancer: current status and obstetrical implications. Best Pract Res Clin Obstet Gynaecol 2019;55:7992.CrossRefGoogle ScholarPubMed
Plante, M, et al. FIGO 2018 stage IB2 (2–4 cm) cervical cancer treated with neo-adjuvant chemotherapy followed by fertility sparing surgery (CONTESSA); neoadjuvant chemotherapy and conservative surgery in cervical cancer to preserve fertility (NEOCON-F). Int J Gynecol Cancer 2019;29:969975.CrossRefGoogle ScholarPubMed
van Kol, KGG, et al. Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer. A systematic review on fertility and recurrence rates. Gynecol Oncol 2019;155:515521.Google ScholarPubMed
Li, X, et al. Reproductive and obstetric outcomes after abdominal radical trachelectomy (ART) for patients with early-stage cervical cancers in Fudan, China. Gynecol Oncol 2020;157:418422.CrossRefGoogle ScholarPubMed
Bentivegna, E, et al. Fertility results and pregnancy outcomes after conservative treatment of cervical cancer: a systematic review of the literature. Fertil Steril 2016;106:11951211(e5).CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×