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Chapter 14 - Oxidative Stress Testing: Direct Tests

Published online by Cambridge University Press:  05 April 2021

By
Renata Finelli ,
Manesh Kumar Panner Selvam  and
Ashok Agarwal
Edited by
Ashok Agarwal ,
Ralf Henkel  and
Ahmad Majzoub
Ashok Agarwal
Affiliation:
The Cleveland Clinic Foundation, Cleveland, OH
Ralf Henkel
Affiliation:
University of the Western Cape, South Africa
Ahmad Majzoub
Affiliation:
Hamad Medical Corporation, Doha
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Summary

Seminal oxidative stress (OS) is a condition where the levels of oxidants overwhelm those of the antioxidants (reductants) present in the semen [1]. The most important oxidants are reactive oxygen species (ROS), a group of oxygen-based molecules including radicals (e.g. superoxide anion – O2-.; hydroxyl radical – OH.; peroxyl radicals – ROO.; alkoxyl radicals – RO.; organic hydroperoxides – ROOH) and non-radical species (hydrogen peroxide – H2O2). Free radicals are molecules with one or more unpaired electrons in the outer orbit, which are highly reactive towards any kind of cellular components (lipids, proteins and DNA).

Type
Chapter
Information
Manual of Sperm Function Testing in Human Assisted Reproduction , pp. 111 - 122
Publisher: Cambridge University Press
Print publication year: 2021

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