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Chapter 26 - Steroid Hormones and Prostaglandins

Published online by Cambridge University Press:  27 July 2023

By
Anthony E. Michael
Edited by
Asma Khalil  and
Anthony Griffiths
Asma Khalil
Affiliation:
St George's University of London
Anthony Griffiths
Affiliation:
University Hospital of Wales, Cardiff
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Summary

Despite both being derived from lipid substrates, steroid hormones and prostaglandins differ fundamentally in their molecular structures, biosynthetic pathways, mechanisms and speed of action. This chapter covers each of these topics in turn, comparing and contrasting the synthesis and actions of steroids versus prostaglandins. In the final section, the functional interactions between these two families of lipid hormones are considered in the physiological control of myometrial contraction at parturition.

Type
Chapter
Information
Part 1 MRCOG Synoptic Revision Guide , pp. 259 - 268
Publisher: Cambridge University Press
Print publication year: 2023

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References

References

Miller, WL, Auchus, RJ (2011) The molecular biology, biochemistry and physiology of human steroidogenesis and its disorders. Endocr Rev 2: 81–151CrossRefGoogle Scholar
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Mesiano, S (2007) Myometrial progesterone responsiveness. Semin Reprod Med 25: 5–13CrossRefGoogle ScholarPubMed

Further Reading

Arrowsmith, S, Wray, S (2014) Oxytocin: Its mechanism of action and receptor signalling in the myometrium. J Neuroendocrinol 26: 356–369Google Scholar
Breyer, RM, Bagdassarian, CK, Myers, SA, Breyer, MD (2001) Prostanoid receptors: Subtypes and signaling. Annu Rev Pharmacol Toxicol 41: 661–690Google Scholar
Buxton, IL (2004) Regulation of uterine function: A biochemical conundrum in the regulation of smooth muscle contraction. Mol Pharmacol 65: 1051–1059CrossRefGoogle Scholar
Castillo, AF, Orlando, U, Helfenberger, KE, Poderoso, C, Podesta, EJ (2015) The role of mitochondrial fusion and StAR phosphorylation in the regulation of StAR activity and steroidogenesis. Mol Cell Endocrinol 408: 73–79CrossRefGoogle ScholarPubMed
Challis, JR, Patel, FA, Pomini, F (1999) Prostaglandin dehydrogenase and the initiation of labour. J Perinat Med 27: 26–34CrossRefGoogle Scholar
Christiaens, I, Zaragoza, DB, Guilbert, L, Robertson, SA, Mitchell, BF, Olson, DM (2008) Inflammatory processes in preterm and term parturition. J Reprod Immunol 79: 50–57CrossRefGoogle ScholarPubMed
Miller, WL (2013) Steroid hormone synthesis in the mitochondria. Mol Cell Endocrinol 379: 62–73CrossRefGoogle Scholar
Pasqualini, JR (2005) Enzymes involved in the formation and transformation of steroid hormones in the fetal and placental compartments. J Steroid Biochem Mol Biol 97: 401–415CrossRefGoogle ScholarPubMed
Rone, MB, Fan, J, Papdopoulos, V (2009) Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. Biochim Biophys Acta 1791: 646–658Google Scholar
Sfakianaki, AK, Norwitz, ER (2006) Mechanisms of progesterone action in inhibiting prematurity. J Matern Fetal Neonatal Med 19: 763–772CrossRefGoogle ScholarPubMed
Stocco, DM (2002) Clinical disorders associated with abnormal cholesterol transport: mutations in the steroidogenic acute regulatory protein. Mol Cell Endocrinol 191: 19–25CrossRefGoogle ScholarPubMed
Sugimoto, Y, Inazumi, T, Tsuchiya, S (2015) Roles of prostaglandin receptors in female reproduction. J Biochem 157: 73–80CrossRefGoogle ScholarPubMed
Xu, L, Glass, CK, Rosenfeld, MG (1999) Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Genet Dev 9: 140–147Google Scholar

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