Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-xfwgj Total loading time: 0 Render date: 2024-06-30T04:36:14.770Z Has data issue: false hasContentIssue false

Chapter 17 - Movement disorders in the elderly

from Section III - Care of the elderly by organ system

Published online by Cambridge University Press:  05 June 2016

Jan Busby-Whitehead
Affiliation:
University of North Carolina
Christine Arenson
Affiliation:
Thomas Jefferson University, Philadelphia
Samuel C. Durso
Affiliation:
The Johns Hopkins University School of Medicine
Daniel Swagerty
Affiliation:
University of Kansas
Laura Mosqueda
Affiliation:
University of Southern California
Maria Fiatarone Singh
Affiliation:
University of Sydney
William Reichel
Affiliation:
Georgetown University, Washington DC
Get access

Summary

The most common movement disorders encountered in the geriatric patient population are Parkinson’s disease and related forms of parkinsonism, followed by tremors, gait disorders, and ataxia. Key clinical features allow the clinician to make the appropriate diagnosis and to develop the subsequent treatment plan to manage the disorder.
Type
Chapter
Information
Reichel's Care of the Elderly
Clinical Aspects of Aging
, pp. 245 - 263
Publisher: Cambridge University Press
Print publication year: 2016

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Schneider, SA, Deuschl, G. The treatment of tremor. Neurotherapeutics 2014; 11: 128–38.Google Scholar
Zesiewicz, TA, Elble, R, Louis, ED, et al. Practice parameter: therapies for essential tremor: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2005; 64:2008–20.Google Scholar
Koller, W, Pahwa, R, Busenbark, K, et al. High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol 1997; 42:292–9.Google Scholar
Schuurman, PR, Bosch, DA, Bossuyt, PM, et al. A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl J Med 2000; 342:461–8.Google Scholar
Deuschl, G, Bain, P, Brin, M. Consensus statement of the Movement Disorder Society on Tremor: ad hoc scientific committee. Mov Disord 1998; 13(Suppl 3):223.Google Scholar
Tyrer, P, Alexander, MS, Regan, A, Lee, I. An extrapyramidal syndrome after lithium therapy. Br J Psychiatry 1980; 136:191–4.CrossRefGoogle ScholarPubMed
Niethammer, M, Ford, B. Permanent lithium-induced cerebellar toxicity: three cases and review of literature. Mov Disord 2007; 22:570–3.CrossRefGoogle ScholarPubMed
Baumann, C. Epidemiology, diagnosis and differential diagnosis in Parkinson’s disease tremor. Parkinsonism and Related Disorders 2012; 18(Suppl 1):S9092.CrossRefGoogle ScholarPubMed
Hughes, AJ, Daniel, SE, Blankson, S, Lees, AJ. A clinicopathologic study of 100 cases of Parkinson’s disease. Arch Neurol 1993; 50:140–8.Google Scholar
Respondek, G, Stamelou, M, Kurz, C, et al. The phenotypic spectrum of progressive supranuclear palsy: a retrospective multicenter study of 100 definite cases. Mov Disord. 2014 Dec;29(14):1758–66.CrossRefGoogle ScholarPubMed
Cummings, JL. Reconsidering diagnostic criteria for dementia with lewy bodies. Highlights from the Third International Workshop on Dementia with Lewy Bodies and Parkinson’s Disease Dementia, September 17–20, 2003, Newcastle Upon Tyne, United Kingdom. Rev Neurol Dis 2004 Winter;1(1):31–4.Google Scholar
Wenning, GK, Geser, F, Krismer, F, et al. The natural history of multiple system atrophy: a prospective European cohort study. Lancet Neurol 2013 Mar;12(3):264–74.Google Scholar
Armstrong, MJ, Litvan, I, Lang, AE, et al. Criteria for the diagnosis of corticobasal degeneration. Neurology 2013 Jan 29;80(5):496503.Google Scholar
Winikates, J, Jankovic, J. Clinical correlates of vascular parkinsonism. Arch Neurol 1999; 56:98102.Google Scholar
Langston, JW, Ballard, P. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson’s disease. Can J Neurol Sci 1984; 11:160–5.Google ScholarPubMed
Olanow, CW. Manganese-induced parkinsonism and Parkinson’s disease. Ann N Y Acad Sci 2004; 1012:209–23.Google Scholar
Klawans, HL, Stein, RW, Tanner, CM, Goetz, CG. A pure parkinsonian syndrome following acute carbon monoxide intoxication. Arch Neurol 1982; 39:302–4.Google Scholar
Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson’s disease. N Engl J Med 1993; 328:176–83.Google Scholar
Shults, CW, Oakes, D, Kieburtz, K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002; 59:1541–50.Google Scholar
Whone, AL, Watts, RL, Stoessl, AJ, et al. Slower progression of Parkinson’s disease with ropinirole versus levodopa: the REAL-PET study. Ann Neurol 2003; 54:93101.Google Scholar
Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs. levodopa on Parkinson disease progression. JAMA 2002; 287:1653–61.Google Scholar
Parkinson Study Group. A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study. Arch Neurol 2002; 59:1937–43.Google Scholar
Calne, DB. The role of various forms of treatment in the management of Parkinson’s disease. Clin Neuropharmacol 1982; 5(Suppl 1):S3843.Google Scholar
Pritchett, AM, Morrison, JF, Edwards, WD, et al. Valvular heart disease in patients taking pergolide. Mayo Clin Proc 2002; 77:1280–6.Google Scholar
Voon, V, Sohr, M, Lang, AE, et al. Impulse control disorders in Parkinson disease: a multicenter case–control study. Ann Neurol. 2011 Jun;69(6):986–96.Google Scholar
Rascol, O, Brooks, DJ, Korczyn, AD, et al. A five-year study of the incidence of dyskinesia in patients with early Parkinson’s disease who were treated with ropinirole or levodopa: 056 study group. N Engl J Med 2000; 342: 1484–91.CrossRefGoogle ScholarPubMed
Parkinson Study Group. Pramipexole vs levodopa as initial treatment for Parkinson disease: a randomized controlled trial. Parkinson Study Group. JAMA 2000; 284:1931–8.Google Scholar
Cilia, R, Akpalu, A, Sarfo, FS, et al. “The modern pre-levodopa era of Parkinson’s disease: insights into motor complications from sub-Saharan Africa.” Brain 137 2014;10:2731–42.Google Scholar
Stowe, RL, Ives, NJ, Clarke, C, et al. Dopamine agonist therapy in early Parkinson’s disease. Cochrane Database Syst Rev 2008;2:CD006564.Google Scholar
PD MED Collaborative Group. Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson’s disease (PD MED): a large, open-label, pragmatic randomised trial.The Lancet 2014;384(9949):1196–205.Google Scholar
Hauser, RA, Hsu, A, Kell, S, et al. Extended-release carbidopa-levodopa (IPX066) compared with immediate-release carbidopa-levodopa in patients with Parkinson’s disease and motor fluctuations: a phase 3 randomised, double-blind trial. Lancet Neurol 2013;12(4):346–56.Google Scholar
Fernandez, HH, Standaert, DG, Hauser, RA, et al. Levodopa-carbidopa intestinal gel in advanced Parkinson’s disease: final 12-month, open-label results. Mov Disord 2015 Apr;30(4):500–9.Google Scholar
Zibetti, M, Merola, A, Artusi, CA, et al. Levodopa/carbidopa intestinal gel infusion in advanced Parkinson’s disease: a 7-year experience. Eur J Neurol 2014 Feb;21(2):312–18.CrossRefGoogle Scholar
Uncini, A, Eleopra, R, Onofrj, M. Polyneuropathy associated with duodenal infusion of levodopa in Parkinson’s disease: features, pathogenesis and management. J Neurol Neurosurg Psychiatry 2015 May;86(5):490–5.Google Scholar
Rinne, UK, Rinne, JO, Rinne, JK, et al. Brain receptor changes in Parkinson’s disease in relation to the disease process and treatment. J Neural Transm Suppl 1983; 18:279–86.Google Scholar
Lew, MF, Kricorian, G. Results from a 2-year centralized tolcapone liver enzyme monitoring program. Clin Neuropharmacol 2007 Sep–Oct;30(5):281–6.Google Scholar
Martinez-Ramirez, D, Okun, MS. Rationale and clinical pearls for primary care doctors referring patients for deep brain stimulation. Gerontology 2014;60(1):3848.Google Scholar
Perestelo-Pérez, L, Rivero-Santana, A, Pérez-Ramos, J, et al. Deep brain stimulation in Parkinson’s disease: meta-analysis of randomized controlled trials. J Neurol 2014 Nov;261(11):2051–60.Google Scholar
Mouradian, MM, Heuser, IJ, Baronti, F, Chase, TN. Modification of central dopaminergic mechanisms by continuous levodopa therapy for advanced Parkinson’s disease. Ann Neurol 1990; 27:1823.Google Scholar
Block, G, Liss, C, Reines, S, et al. Comparison of immediate-release and controlled release carbidopa/levodopa in Parkinson’s disease: a multicenter 5-year study. The CR First Study Group. Eur Neurol 1997;37:23–7.CrossRefGoogle Scholar
Nutt, JG, Woodward, WR, Beckner, RM, et al. Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients. Neurology 1994;44:913–9.Google Scholar
Parkinson Study Group. Entacapone improves motor fluctuations in levodopa-treated Parkinson’s disease patients. Ann Neurol 1997;42:747–55.Google Scholar
Rajput, AH, Martin, W, Saint-Hilaire, MH, Dorflinger, E, Pedder, S. Tolcapone improves motor function in parkinsonian patients with the “wearing-off” phenomenon: a double-blind, placebo-controlled, multicenter trial. Neurology 1997;49:1066–71.Google Scholar
Pourfar, M, Feigin, A, Eidelberg, D. Natural history. In: Factor, SA, Weiner, WJ, editors, Parkinson’s Disease: Diagnosis and Clinical Management. 2nd ed. New York: Demos; 2008: 127–33.Google Scholar
Ostergaard, K, Aa Sunde, N. Evolution of Parkinson’s disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus. Mov Disord 2006;21:624631.CrossRefGoogle ScholarPubMed
Marras, C, McDermott, MP, Rochon, PA, et al. Survival in Parkinson disease: thirteen-year follow-up of the DATATOP cohort. Neurology 2005;64(1):8793.Google Scholar
Tuck, K, Brod, L, Nutt, J, Fromme, EK. Preferences of patients with Parkinson. American Journal of Hospice & Palliative Medicine 2015;32(1):6877.Google Scholar
Verghese, J, Le Valley, A, Hall, CB, et al. Epidemiology of gait disorders in community-residing older adults. Journal of American Geriatric Society 2006;54:255–61.Google Scholar
Sudarsky, LR. Gait impairment and falls. In: Samuels, S and Feske, S, eds. Office Practice of Neurology. Philadelphia: Churchill Livingstone; 2003: 25.CrossRefGoogle Scholar
Marmarou, A, Black, P, Bergsneider, M, et al. Guidelines for management of idiopathic normal pressure hydrocephalus: progress to date. Acta Neurochir Suppl 2005;95:237–40.Google Scholar
Perlman, SL. Ataxias. Clin Geriatr Med 2006; 22:859–77.CrossRefGoogle ScholarPubMed
Zesiewicz, TA, Sullivan, KL, Arnulf, I, et al. Practice parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2010;74(11):924–31.Google Scholar
Ruzicka, E, Jankovic, JJ. Disorders of gait. In: Jankovic, J and Tolosa, E, eds. Parkinsons Disease and Movement Disorders. Philadelphia: Lippincott Williams & Wilkins; 2007: 409.Google Scholar
Mouton, CP, Espino, DV. Health screening in older women. Am Fam Physician 1999;59(7):1835–42.Google Scholar
Barak, Y, Wagenaar, RC, Holt, KG. Gait characteristic of elderly people with a history of falls: a dynamic approach. Phys Ther 2006 86:1501–10.Google Scholar
Gilman, S. Merritt’s Neurology. 10th ed. Philadelphia: Lippincott Williams & Wilkins, 2000.Google Scholar
Ondo, W. Gait and balance disorders. Med Clin N Am 2003;87(4): 793801.Google Scholar
Hyndman, D, Ashburn, A, Yardley, L, Stack, E. Interference between balance, gait, and cognitive task performance among people with stroke living in the community. Disability and Rehabilitation. 2006;28(13–14):849–56.CrossRefGoogle ScholarPubMed
Nutt, JG. Abnormalities of posture and movement. In: Cassel, CK, Cohen, HJ, Larson, EB, et al. (eds). Geriatric Medicine. 3rd ed. New York: Spring-Verlag; 1997: 939–48.Google Scholar
Factora, R, Luciano, M. Normal pressure hydrocephalus: diagnosis and new approaches to treatment. Clin Geriatr Med 2006;22:645–57.Google Scholar
Kanade, RV, van Deursen, RWM, Harding, K, Price, P. Walking performance in people with diabetic neuropathy: benefits and threats. Diabetologia 2006;49:1747–54.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×