Book contents
- Marijuana and Madness
- Marijuana and Madness
- Copyright page
- Contents
- Contributors
- Preface
- 1 How cannabis works in the brain
- 2 Other cannabinoids
- 3 The function of the endocannabinoid system
- 4 Is cannabis becoming more potent?
- 5 What are the policy implications of the evidence on cannabis and psychosis?
- 6 Cannabis, endocannabinoids and neurodevelopment
- 7 The impact of pubertal exposure to cannabis on the brain: a focus on animal studies
- 8 Cannabis and cognition: short- and long-term effects
- 9 Does cannabis cause lasting brain damage?
- 10 The association between cannabis use and depression: a review of the evidence
- 11 Cannabis, cannabinoids and bipolar disorder
- 12 Which cannabis users develop psychosis?
- 13 Cannabinoids and the cerebellum: a potential role in the development of psychosis
- 14 The neural basis for the acute effects of cannabis on learning and psychosis
- 15 Does cannabis use cause schizophrenia? The epidemiological evidence
- 16 Postmortem studies of the brain cannabinoid system in schizophrenia
- 17 The endocannabinoid system in schizophrenia
- 18 The acute effects of cannabinoids in patients with psychotic illness
- 19 Cannabis abuse and the course of schizophrenia
- 20 Understanding cannabis use in schizophrenia
- 21 Addressing cannabis use in people with psychosis
- Index
14 - The neural basis for the acute effects of cannabis on learning and psychosis
Published online by Cambridge University Press: 05 November 2011
Book contents
- Marijuana and Madness
- Marijuana and Madness
- Copyright page
- Contents
- Contributors
- Preface
- 1 How cannabis works in the brain
- 2 Other cannabinoids
- 3 The function of the endocannabinoid system
- 4 Is cannabis becoming more potent?
- 5 What are the policy implications of the evidence on cannabis and psychosis?
- 6 Cannabis, endocannabinoids and neurodevelopment
- 7 The impact of pubertal exposure to cannabis on the brain: a focus on animal studies
- 8 Cannabis and cognition: short- and long-term effects
- 9 Does cannabis cause lasting brain damage?
- 10 The association between cannabis use and depression: a review of the evidence
- 11 Cannabis, cannabinoids and bipolar disorder
- 12 Which cannabis users develop psychosis?
- 13 Cannabinoids and the cerebellum: a potential role in the development of psychosis
- 14 The neural basis for the acute effects of cannabis on learning and psychosis
- 15 Does cannabis use cause schizophrenia? The epidemiological evidence
- 16 Postmortem studies of the brain cannabinoid system in schizophrenia
- 17 The endocannabinoid system in schizophrenia
- 18 The acute effects of cannabinoids in patients with psychotic illness
- 19 Cannabis abuse and the course of schizophrenia
- 20 Understanding cannabis use in schizophrenia
- 21 Addressing cannabis use in people with psychosis
- Index
Summary
Studies that provide mechanistic evidence delineating how the enhancement of the risk of psychosis by cannabis may be mediated at the neural level in humans are important. The modulatory effects of tetrahydrocannabinol (THC) on medial temporal, anterior cingulate/medial prefrontal and striatal activation during verbal learning were observed in the absence of differential task performance between the drug conditions. This chapter summarizes the evidence from studies that have examined the acute neural effects of cannabis and its main psychoactive ingredients during cognitive tasks, as well as on resting state activity of the brain. The acute effects of cannabis on neural activity during cognitive processing paradigms apart from learning have been examined by few other studies. Studies are underway that aim to provide mechanistic insights into the genetic modulation of the acute symptomatic, cognitive and neural effects of cannabis in humans.
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- Marijuana and Madness , pp. 160 - 168Publisher: Cambridge University PressPrint publication year: 2011