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A single nucleotide polymorphism in SLC1A1 gene is associated with age of onset of obsessive-compulsive disorder

Published online by Cambridge University Press:  15 April 2020

S. Dallaspezia ,
M. Mazza ,
C. Lorenzi ,
F. Benedetti  and
E. Smeraldi
S. Dallaspezia*
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
M. Mazza
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
C. Lorenzi
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
F. Benedetti
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
E. Smeraldi
Affiliation:
Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy
*
*Corresponding author. Istituto Scientifico Ospedale San Raffaele, Department of Clinical Neurosciences, San Raffaele Turro, Via Stamira d’Ancona 20, Milano, Italy. Tel.: +39 2 264 331 56; fax: +39 2 264 332 65. E-mail address:dallaspezia.sara@hsr.it (S. Dallaspezia).
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Abstract

Different genetic polymorphisms in the SLC1A1 have been shown to be associated with obsessive-compulsive disorder. Rs301430 is a T/C functional polymorphism affecting the gene expression and extrasynaptic glutamate concentration.We observed that Rs301430 influence age at onset in obsessive-compulsive disorder.

Keywords

Obsessive-compulsive disorderSLC1A1Age at onsetRs301430Glutamate
Type
Short communications
Information
European Psychiatry , Volume 29 , Issue 5 , June 2014 , pp. 301 - 303
Copyright
Copyright © Elsevier Masson SAS 2014

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