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Antipsychotic prescribing in youths: A French community-based study from 2006 to 2013

Published online by Cambridge University Press:  15 April 2020

H. Verdoux ,
E. Pambrun ,
S. Cortaredona ,
M. Tournier  and
P. Verger
H. Verdoux*
Affiliation:
University Bordeaux, U657, 33000Bordeaux, France Inserm, U657, 33000Bordeaux, France Centre hospitalier Charles-Perrens, Bordeaux33000, France
E. Pambrun
Affiliation:
University Bordeaux, U657, 33000Bordeaux, France Inserm, U657, 33000Bordeaux, France
S. Cortaredona
Affiliation:
Aix Marseille Université (Aix Marseille School of Economics-SESSTIM UMR 912, Inserm, IRD), Marseille, France Observatoire régional de la santé, Provence-Alpes-Côte d’Azur (ORS PACA), Marseille, France
M. Tournier
Affiliation:
University Bordeaux, U657, 33000Bordeaux, France Inserm, U657, 33000Bordeaux, France Centre hospitalier Charles-Perrens, Bordeaux33000, France
P. Verger
Affiliation:
Aix Marseille Université (Aix Marseille School of Economics-SESSTIM UMR 912, Inserm, IRD), Marseille, France Observatoire régional de la santé, Provence-Alpes-Côte d’Azur (ORS PACA), Marseille, France
*
*E-mail address: hverdoux@ch-perrens.fr (H. Verdoux)

Abstract

Objectives

To explore in a community-based sample of persons aged 0–25 years:

– trends in antipsychotic prescribing;

– characteristics of the zone of residence associated with antipsychotic prescribing rates;

– the pattern of antipsychotic prescribing.

Methods

The study was performed using reimbursement data from the French Insurance Healthcare system. Prescribing trends were investigated over the period 2006–2013. An ecological design was used to assess the impact of the socio-economical and health resource characteristics of the zone of residence (n = 96 administrative subdivisions of French territory) on antipsychotic prescribing rates. The pattern of antipsychotic prescribing was explored in a cohort of youths newly treated with antipsychotics.

Results

Over the period 2006–2013, antipsychotic dispensing rates were globally stable in persons aged 0–25 years (4.8 per 1000 in 2006 and 4.9 per 1000 in 2013). First-generation antipsychotic dispensing rates decreased from 3.1 to 2.6 per 1000 (OR = 0.96, 95% CI = 0.94–0.98), while second-generation antipsychotic dispensing rates increased from 2.7 to 3.4 per 1000 (OR = 1.03, 95% CI = 1.01–1.05). Antipsychotic prescribing rates were impacted by health resource characteristics of the zone of residence in children aged 10 years and under and by socio-economical characteristics in those aged 16–20 years. In all the age groups, antipsychotics were principally started by hospital practitioners (47%) and general practitioners (34%). The rates of psychostimulants concomitantly prescribed with antipsychotics were lower than 5%.

Conclusion

Rates of youths exposed to second-generation antipsychotics are still rising. The impact of environmental characteristics on antipsychotics prescribing and appropriateness of these prescriptions in youths should be further investigated.

Keywords

AntipsychoticUseChildrenAdolescents
Type
Congrès français de psychiatrie: Rencontres avec l’expert
Information
European Psychiatry , Volume 30 , Issue S2: HS1 - Congrès Français de Psychiatrie 2015 , November 2015 , pp. S9 - S10
Copyright
Copyright © European Psychiatric Association 2015

Disclosure of interest

M. Tournier a reçu des honoraires comme orateur par Janssen, BMS, AstraZeneca.

H. Verdoux, E. Pambrun, S. Cortaredona, P. Verger declare that they have no competing interest.

References

Further reading

Verdoux, HPambrun, ECortaredona, STournier, MVerger, P. Antipsychotic prescribing in youths: a French community-based study from 2006 to 2013. Eur Child Adolesc Psychiatry 2015.CrossRefGoogle Scholar
Olfson, MBlanco, CLiu, SMWang, SCorrell, CU. National trends in the office-based treatment of children, adolescents, and adults with antipsychotics. Arch Gen Psychiatry 2012;69:1247–56.CrossRefGoogle ScholarPubMed
Olfson, MBlanco, CLiu, LMoreno, CLaje, G. National trends in the outpatient treatment of children and adolescents with antipsychotic drugs. Arch Gen Psychiatry 2006;63:679–85.CrossRefGoogle ScholarPubMed
Patten, SBWaheed, WBresee, L. A review of pharmacoepidemiologic studies of antipsychotic use in children and adolescents. Can J Psychiatry 2012;57:717–21CrossRefGoogle ScholarPubMed
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