Hostname: page-component-76fb5796d-skm99 Total loading time: 0 Render date: 2024-04-26T04:44:18.962Z Has data issue: false hasContentIssue false
  • English
  • Français

Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder

Published online by Cambridge University Press:  16 April 2020

Marijn Lijffijt ,
J. Leon Kenemans ,
Annemiek ter Wal ,
Elise H. Quik ,
C. Kemner ,
Herman Westenberg ,
Marinus N. Verbaten  and
Herman van Engeland
Marijn Lijffijt*
Affiliation:
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584CAUtrecht, The Netherlands
J. Leon Kenemans
Affiliation:
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584CAUtrecht, The Netherlands Department of Psychonomics, Utrecht University, Utrecht, The Netherlands
Annemiek ter Wal
Affiliation:
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584CAUtrecht, The Netherlands Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Elise H. Quik
Affiliation:
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584CAUtrecht, The Netherlands
C. Kemner
Affiliation:
Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Herman Westenberg
Affiliation:
Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
Marinus N. Verbaten
Affiliation:
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584CAUtrecht, The Netherlands
Herman van Engeland
Affiliation:
Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
*
*Corresponding author. Present address: Department of Psychiatry and Behavioral Sciences, The university of Texas Medical Branch at Galveston, 301 University Boulevard, Galveston, TX 77555-0189, USA. Tel.: +1 409 747 9682; fax: +1 409 747 8351. E-mail address: malijffi@utmb.edu (M. Lijffijt).
Get access

Abstract

Purpose

The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention.

Subjects and methods

Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.

Results

Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively.

Discussion and conclusion

In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles.

Keywords

Attention-deficit/hyperactivity disorderMethylphenidateStop-signal paradigmInhibitory controlAttentionBlood serum
Type
Short communication
Information
European Psychiatry , Volume 21 , Issue 8 , December 2006 , pp. 544 - 547
Copyright
Copyright © Elsevier Masson SAS 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
Aston-Jones, G., Rajkowski, J., Cohen, J.Role of locus coeruleus in attention and behavioral flexibility Biol. Psychiatry 1999; 46:1309–1320.CrossRefGoogle ScholarPubMed
Band, G.P., van Boxtel, G.J.Inhibitory motor control in stop paradigms: review and reinterpretation of neural mechanisms Acta Psychol. (Amst.) 1999; 101:179–211.CrossRefGoogle ScholarPubMed
Bedard, A.C., Ickowicz, A., Logan, G.D., Hogg-Johnson, S., Schachar, R., Tannock, R.Selective inhibition in children with attention-deficit hyperactivity disorder off and on stimulant medication J. Abnorm. Child Psychol. 2003; 31:315–327.CrossRefGoogle ScholarPubMed
Castellanos, F.X., Elia, J., Kruesi, M.J.P., Gulotta, C.S., Mefford, I.N., Potter, W.Z.et al.Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder Psychiatry Res. 1994; 52:305–316.CrossRefGoogle ScholarPubMed
Castellanos, F.X., Elia, J., Kruesi, M.J.P., Marsh, W.L., Gulotta, C.S., Potter, W.Z.et al.Cerebrospinal fluid homovannilic acid predicts behavioral response to stimulants in 45 boys with attention deficit/hyperactivity disorder Neuropsychopharmacol 1996; 14:125–137.CrossRefGoogle Scholar
De Jong, R., Coles, M.G., Logan, G.D.Strategies and mechanisms in nonselective and selective inhibitory motor control J. Exp. Psychol. Hum. Percept. Perform. 1995; 21:498–511.CrossRefGoogle ScholarPubMed
Gorelova, N., Seamans, J.K., Yang, C.R.Mechanisms of dopamine activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex J. Neurophysiol. 2002; 88:3150–3166.CrossRefGoogle ScholarPubMed
Kramer, A.F., Cepeda, N.J., Cepeda, M.L.Methylphenidate effects on task-switching performance in attention-deficit/hyperactivity disorder J. Am. Acad. Child Adolesc. Psychiatry 2001; 40:1277–1284.CrossRefGoogle ScholarPubMed
Lijffijt, M., Kenemans, J.L., Verbaten, M.N., van Engeland, M.A.A meta-analytic review of stopping performance in attention-deficit/hyperactivity desorder: deficient inhibitory motor control? J Abnorm Psychol 2005; 114:216–222.CrossRefGoogle Scholar
Logan, G.D.On the ability to inhibit thought and action: a users’ guide to the stop-signal paradigm. Dagenbach, D., Carr, T.H., Inhibitory processes in attention, memory, and language San Diego: Academic Press; 1994. 189–239.Google Scholar
Maxwell, S.E., Delaney, H.D.Designing experiments and analyzing data: a model comparison perspective Mahwah, NJ: Lawrence Erlbaum Associates; 2000.Google Scholar
Nigg, J.T.Is ADHD a disinhibitory disorder? Psychol. Bull. 2001; 127:571–598.CrossRefGoogle ScholarPubMed
Sergeant, J.A., Geurts, H., Oosterlaan, J.How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder? Behav. Brain Res. 2002; 130:3–28.CrossRefGoogle ScholarPubMed
Scheres, A., Oosterlaan, J., Swanson, J., Morein-Zamir, S., Meiran, N., Schut, H.et al.The effect of methylphenidate on three forms of response inhibition in boys with AD/HD J. Abnorm. Child Psychol. 2003; 31:105–120.CrossRefGoogle ScholarPubMed
Tannock, R., Schachar, R.J., Carr, R.P., Chajczyk, D., Logan, G.D.Effects of methylphenidate on inhibitory motor control in hyperactive children J. Abnorm. Child Psychol. 1989; 17:473–491.CrossRefGoogle Scholar
Tannock, R., Schachar, R., Logan, G.Methylphenidate and cognitive flexibility: dissociated dose effect in hyperactive children J. Abnorm. Child Psychol. 1995; 23:235–266.CrossRefGoogle Scholar
Volkow, N.D., Wang, G., Fowler, J.S., Telang, F., Maynard, L., Logan, J.et al.Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain Am. J. Psychiatry 2004; 161:1173–1180.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.