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Corrigendum to “TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia” [Eur Psychiatry 50 (2018) 7–20]

Published online by Cambridge University Press:  01 January 2020

Alberto Del Guerra*
Affiliation:
aDipartimento di Fisica “E. Fermi”, Università di Pisa, and INFN, Sezione di Pisa, Pisa, Italy
Salleh Ahmad
Affiliation:
bWeeroc s.a.s., Palaiseau, France
Mihai Avram
Affiliation:
cNuklearmedinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany dDepartment of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany eNeuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universität München, Munich, Germany
Nicola Belcari
Affiliation:
aDipartimento di Fisica “E. Fermi”, Università di Pisa, and INFN, Sezione di Pisa, Pisa, Italy
Arne Berneking
Affiliation:
fForschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM4, Jülich, Germany
Laura Biagi
Affiliation:
gIRCSS, Stella Maris, Calambrone, Pisa, Italy
Maria Giuseppina Bisogni
Affiliation:
aDipartimento di Fisica “E. Fermi”, Università di Pisa, and INFN, Sezione di Pisa, Pisa, Italy
Felix Brandl
Affiliation:
dDepartment of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany eNeuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universität München, Munich, Germany
Jorge Cabello
Affiliation:
cNuklearmedinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
Niccolò Camarlinghi
Affiliation:
aDipartimento di Fisica “E. Fermi”, Università di Pisa, and INFN, Sezione di Pisa, Pisa, Italy
Piergiorgio Cerello
Affiliation:
hIstituto Nazionale di Fisica Nucleare, Sezione di Torino, Torino, Italy
Chang-Hoon Choi
Affiliation:
fForschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM4, Jülich, Germany
Silvia Coli
Affiliation:
hIstituto Nazionale di Fisica Nucleare, Sezione di Torino, Torino, Italy
Sabrina Colpo
Affiliation:
iAdvansid s.r.l., Povo, Trento, Italy
Julien Fleury
Affiliation:
bWeeroc s.a.s., Palaiseau, France
Vito Gagliardi
Affiliation:
aDipartimento di Fisica “E. Fermi”, Università di Pisa, and INFN, Sezione di Pisa, Pisa, Italy
Giuseppe Giraudo
Affiliation:
hIstituto Nazionale di Fisica Nucleare, Sezione di Torino, Torino, Italy
Karsten Heekeren
Affiliation:
jDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, University of Zurich, Switzerland
Wolfram Kawohl
Affiliation:
jDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, University of Zurich, Switzerland kDepartment of Psychiatry and Psychotherapy, Psychiatric Services of Aargovia, Switzerland
Theodora Kostou
Affiliation:
lTechnological Educational Institute of Athens, Greece
Jean-Luc Lefaucheur
Affiliation:
mInviscan s.a.s., France
Christoph Lerche
Affiliation:
fForschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM4, Jülich, Germany
George Loudos
Affiliation:
lTechnological Educational Institute of Athens, Greece
Matteo Morrocchi
Affiliation:
aDipartimento di Fisica “E. Fermi”, Università di Pisa, and INFN, Sezione di Pisa, Pisa, Italy
Julien Muller
Affiliation:
nRS2Ds.a.s., Mundolsheim, France
Mona Mustafa
Affiliation:
cNuklearmedinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
Irene Neuner
Affiliation:
fForschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM4, Jülich, Germany nRS2Ds.a.s., Mundolsheim, France
Panagiotis Papadimitroulas
Affiliation:
lTechnological Educational Institute of Athens, Greece
Francesco Pennazio
Affiliation:
hIstituto Nazionale di Fisica Nucleare, Sezione di Torino, Torino, Italy
Ravichandran Rajkumar
Affiliation:
fForschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM4, Jülich, Germany oDepartment of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen University, JARA Brain, Aachen, Germany
Cláudia Régio Brambilla
Affiliation:
fForschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM4, Jülich, Germany
Julien Rivoire
Affiliation:
nRS2Ds.a.s., Mundolsheim, France
Elena Rota Kops
Affiliation:
fForschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM4, Jülich, Germany
Jürgen Scheins
Affiliation:
fForschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM4, Jülich, Germany
Rémy Schimpf
Affiliation:
nRS2Ds.a.s., Mundolsheim, France
N. Jon Shah
Affiliation:
fForschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM4, Jülich, Germany
Christian Sorg
Affiliation:
dDepartment of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany eNeuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universität München, Munich, Germany qDepartment of Psychiatry, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
Giancarlo Sportelli
Affiliation:
aDipartimento di Fisica “E. Fermi”, Università di Pisa, and INFN, Sezione di Pisa, Pisa, Italy
Michela Tosetti
Affiliation:
gIRCSS, Stella Maris, Calambrone, Pisa, Italy
Riccardo Trinchero
Affiliation:
hIstituto Nazionale di Fisica Nucleare, Sezione di Torino, Torino, Italy
Christine Wyss
Affiliation:
jDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, University of Zurich, Switzerland
Sibylle Ziegler
Affiliation:
cNuklearmedinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany pDepartment of Nuclear Medicine, University Hospital, LMU, Munich, Germany
*
*Corresponding author. E-mail address: http://www.trimage.eu

Abstract

Type
Corrigendum
Copyright
Copyright © European Psychiatric Association 2018

This Corrigendum for the article ‘TRIMAGE: a dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia’ by A. Del Guerra and colleagues, concerns the analyses and results of the F-DOPA PET data assessed in Munich. Particularly, it concerns the section ‘Results’, subsection ‘3.1.2. Results of the pilot study: analysis of Munich data’ and corresponding Figure 7, as well as parts of the Discussion.

The authors noted that in the analysis of Munich F-DOPA PET data, influx rate constants (Kc) were wrongly calculated. Specifically, in the calculation of the integral used in the Patlak graphical analysis, PET frames were treated as equidistant, which led to higher than normal Kc values. We recalculated the Kc values with the correct integral (taking into account different frame lengths) and ran several control analyses to assess their reliability.

In detail, the corrections affect the following parts of the article:

1) Results, section ‘3.1.2. Analysis of the Munich data’: in the last 2 paragraphs, the sentences “Schizophrenic patients showed …. or other striatal sub-regions.” have to be replaced by the following: “Schizophrenic patients showed decreased Kc values in the caudate nucleus (0.0103 ± 0.001 min−1) compared to healthy controls (0.0132 ± 0.001 min−1) (p < 0.001) (Figure 7, upper left). Similarly, a decrease of Kc values was found in the functional executive region (Figure 7, lower left), which largely overlaps with the anatomical region of the caudate, for schizophrenic patients (0.0120 ± 0.001 min−1) compared to controls (0.0145 ± 0.001 min−1) (p = 0.002). Additionally, patients showed decreased Kc values in the putamen (Figure 7, center upper part) (0.0131 ± 0.001 min−1) compared to healthy controls (0.0152 ± 0.002 min−1) (p = 0.017), and the functional correspondent in the sensorimotor striatum (Figure 7, center lower part) for patients (0.0119 ± 0.002 min−1) compared to healthy controls (0.0160 ± 0.002 min−1) (p < 0.001). Finally, a decrease in Kc values was found for the whole striatum (Figure 7, right) in patients (0.0120 ± 0.001 min−1) compared to healthy controls (0.0144 ± 0.001 min−1) (p = 0.002). No differences were found for the accumbens nucleus (p = 0.71) and the corresponding functional subdivision, namely the limbic striatum (p = 0.65).”

2) Figure 7 of the article has to be replaced by the following new Figure 7:

3) In the section ‘4. Discussion and conclusions’, second paragraph, the sentence “The evaluation shows that group differences between healthy controls and schizophrenic patients are well replicable.” has to be deleted, since these findings are rather novel and surprising and therefore do not directly replicate previous results.

This correction applies to the following article(s):

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