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Heracleum persicum: chemical composition, biological activities and potential uses in poultry nutrition

  • L. CHANGXING (a1), D. DONGFANG (a1), Z. LIXUE (a2), M. SAEED (a3), M. ALAGAWANY (a4), M.R. FARAG (a5), M. CHENLING (a6) and L. JIANHUA (a1)...

Abstract

Heracleum persicum (golpar) is an endemic medicinal plant that is commonly known as hogweed or Persian hogweed. It contains flavonoids and furanocoumarins that probably could stimulate both cell- and antibody-mediated immune responses. Besides, golpar has a substantial immunostimulatory effect on beta-lymphocytes and macrophages that played important role in antibody synthesis. Its extract at a supplementation level of 1-2.5 ml/l in drinking water showed a remarkable increase in the total immunoglobulins (Ig) (70%), immunoglobulin G (IgG) (100%) and immunoglobulin M (IgM) (94%) titres and an increase in antibody titre against Newcastle disease virus (96%) in broilers. In addition, supplementation positively affected the feed intake (9.4%), weight gain (14.7%) and food conversion ratio (FCR) (8.7%) in broilers. Moreover, in several studies, it has potential as an antifungal, antidiabetic, hypocholesterolaemic and growth enhancer agent; which endorsed its extensive contents of phytochemicals (terpenoids, triterpenes, furanocoumarins, volatile substances, flavonoids and alkaloids). It has a positive effect on the levels of glutathione (GSH), peroxidation lipids (MDA), the total antioxidant capacity of plasma or ferric reducing ability of plasma (FRAP) and glutathione s-transferase (GST), in addition to modulatory effects on liver enzymes including alanine transferase (ALT) and aspartate transferase (AST). After reviewing the published literature, it was apparent that golpar has multidimensional biological effects. Nevertheless, little research is available on the effects of golpar on productive performance and other health-related parameters in avian species. Hence, this review encourages veterinarians and poultry researcher to undertake further work to demonstrate the promising beneficial effects of golpar at effective levels to potentially replace the synthetic antibiotic growth promoters in commercial poultry diets.

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ABOU-ELKHAIR, R., AHMED, H. and SELIM, S. (2014) Effects of black pepper (piper nigrum), turmeric powder (curcuma longa) and coriander seeds (coriandrum sativum) and their combinations as feed additives on growth performance, carcass traits, some blood parameters and humoral immune response of broiler chickens. Asian-Australasian Journal of Animal Sciences 27: 847.
AFRISHAM, R., ABEROMAND, M., GHAFFARI, M.A., SIAHPOOSH, A. and JAMALAN, M. (2015) Inhibitory effect of heracleum persicum and ziziphus jujuba on activity of alpha-amylase. Journal of Botany,2015: Article ID 824683, 8 pages, https://doi.org/10.1155/2015/824683.
AMIN, G. (1991) Iranian traditional medicinal plants. Research Deputy of Health Ministry, Tehran: 130.
AMIZADEH, M., HEJAZI, M.J. and SARYAZDI, G.A. (2013) Fumigant toxicity of some essential oils on tetranychus urticae (acari: Tetranychidae). International Journal of Acarology 39: 285-289.
ARAIN, M.A., MEI, Z., HASSAN, F.U., SAEED, M., ALAGAWANY, M., SHAR, A.H. and RAJPUT, I.R. (2018a) Lycopene: a natural antioxidant for prevention of heat-induced oxidative stress in poultry. World's Poultry Science Journal74: 89-100.
ARAIN, M.A., SAEED, M., HASSAN, F.U., RASHID, I., ZOHAIB, R., BHUTTO, A., ALAGAWANY, M. and SHAR, A.H. (2018b) Health benefits and potential applications of anthocyanins in poultry feed industry. World's Poultry Science Journal 74: 251-264.
ARUOMA, O.I. (2003) Methodological considerations for characterizing potential antioxidant actions of bioactive components in plant foods. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 523: 9-20.
ASGARPANAH, J., MEHRABANI, G.D., AHMADI, M., RANJBAR, R. and ARDEBILY, M.S.-A. (2012) Chemistry, pharmacology and medicinal properties of heracleum persicum desf. Ex fischer: A review. Journal of Medicinal Plants Research 6: 1813-1820.
AYNEHCHI, Y., ALIABADI, Z. and SURMAGHI, M.H. (1978) Fouranocumarins in roots of Heracleum persicum. Acta Horticultrae 73: 103-107.
BAFNA, A. and MISHRA, S. (2009) Antioxidant and immunomodulatory activity of the alkaloidal fraction of cissampelos pareira linn. Scientia pharmaceutica 78: 21-32.
BRUNTON, L.L., LAZO, J.S. and PARKER, K.L. (2006) Goodman & gilman's the pharmacological basis of therapeutics. Mcgraw-hill companies. New York, NY.
CHO, J.Y., PARK, S.C., KIM, T.W., KIM, K.S., SONG, J.C., LEE, H.M., SUNG, H.J., RHEE, M.H., KIM, S.K. and PARK, H.J. (2006) Radical scavenging and anti-inflammatory activity of extracts from opuntia humifusa raf. Journal of Pharmacy & Pharmacology 58: 113.
CHRISTAKI, E., BONOS, E., GIANNENAS, I. and FLOROU-PANERI, P. (2012) Aromatic plants as a source of bioactive compounds. Agriculture 2: 228-243.
CORUH, N., SAGDICOGLU CELEP, A.G. and OZGOKCE, F. (2007) Antioxidant properties of prangos ferulacea (l.) lindl., chaerophyllum macropodum boiss. And heracleum persicum desf. From apiaceae family used as food in eastern anatolia and their inhibitory effects on glutathione-s-transferase. Food Chemistry 100: 1237-1242.
DHAMA, K., KARTHIK, K., KHANDIA, R., MUNJAL, A., TIWARI, R., RANA, R., KHURANA, S.K., ULLAH, S., KHAN, R.U., ALAGAWANY, M., FARAG, M.R., DADAR, M. and JOSHI, S.K. (2018) Medicinal and therapeutic potential of herbs and plant metabolites / extracts countering viral pathogens - current knowledge and future prospects. Current Drug Metabolism 19: 236-263.
DHAMA, K., SAMINATHAN, M., JACOB, S.S., SINGH, M., KARTHIK, K., AMARPAL, , TIWARI, R., SUNKARA, L.T., MALIK, Y.S. and SINGH, R.K. (2015) Effect of immunomodulation and immunomodulatory agents on health with some bioactive principles, modes of action and potent biomedical applications. International Journal of Pharmacology 11: 253-290.
FARAG, M.R. and ALAGAWANY, M. (2019) The role of Astragalus membranaceus as immunomodulator in poultry. World's Poultry Science Journal 75: 43-54, doi.org/10.1017/S0043933918000739.
FRANCIOSINI, M.P., CASAGRANDE-PROIETTI, P., FORTE, C., BEGHELLI, D., ACUTI, G., ZANICHELLI, D., DAL BOSCO, A., CASTELLINI, C. and TRABALZA-MARINUCCI, M. (2016) Effects of oregano (Origanum vulgare l.) and rosemary (rosmarinus officinalis l.) aqueous extracts on broiler performance, immune function and intestinal microbial population. Journal of Applied Animal Research 44: 474-479.
GEETHA, V. and CHAKRAVARTHULA, S.N. (2018) Chemical composition and anti-inflammatory activity of Boswellia ovalifoliolata essential oils from leaf and bark. Journal of Forestry Research 29: 373-381.
GHASEMI, H.A., KASANI, N. and TAHERPOUR, K. (2014) Effects of black cumin seed (Nigella sativa l.), a probiotic, a prebiotic and a synbiotic on growth performance, immune response and blood characteristics of male broilers. Livestock Science 164: 128-134.
HAJHASHEMI, V., SAJJADI, S.E. and HESHMATI, M. (2009) Anti-inflammatory and analgesic properties of heracleum persicum essential oil and hydroalcoholic extract in animal models. Journal of Ethnopharmacology 124: 475-480.
HEMATI, A., AZARNIA, M. and ANGAJI, S.A. (2010) Medicinal effects of heracleum persicum (golpar). Middle East Journal of Scientific Research 5 (3): 174-176.
JADHAV, K., SHARMA, K., KATOCH, S., SHARMA, V. and MANE, B. (2015) Probiotics in broiler poultry feeds: A review. Journal of Animal Nutrition and Physiology 1: 04-16.
JAMSHIDPARVAR, A., JAVANDEL, F., SEIDAVI, A., BLANCO, F.P., MARÍN, A.L.M., RAMÍREZ, C.A., BUENDÍA, E.A. and NÚÑEZ-SÁNCHEZ, N. (2017) Effects of golpar ( heracleum persicum desf.) and probiotics in drinking water on performance, carcass characteristics, organ weights, blood plasma constituents, and immunity of broilers. Environmental Science & Pollution Research 24: 23571.
JAYAPRAKASHA, G., OHNISHI-KAMEYAMA, M., ONO, H., YOSHIDA, M. and JAGANMOHAN RAO, L. (2006) Phenolic constituents in the fruits of cinnamomum zeylanicum and their antioxidant activity. Journal of Agricultural and Food Chemistry 54: 1672-1679.
KAWAKITA, S., GIEDLIN, H. and NOMOTO, K. (2005) Immunomodulators from higher plants. Journal of Natural Medicines 46: 34-38.
KHEIRI, F., RAHIMIAN, Y. and RAFIEE, A. (2014) Effect of Heracleum persicum extract on performance and some haematological parameters in broiler chicks. Research Opinions in Animal & Veterinary Sciences 4: 522-525.
KHOSRAVI, R.A., SHOKRI, H., FARAHNEJAT, Z., CHALANGARI, R. and KATALIN, M. (2013) Antimycotic efficacy of Iranian medicinal plants towards dermatophytes obtained from patients with dermatophytosis. Chinese Journal of Natural Medicines 11: 43-48.
KOUSHA, A. and BAYAT, M. (2012) Bactericidal and fungicidal activity of methanolic extracts of heracleum persicum desf. Ex fischer against some aquatic and terrestrial animal pathogens. International Journal of Pharmacology 8: 652-656.
LEE, K.W., KIM, J.S. and OH, S.T. (2015) Effects of dietary sanguinarine on growth performance, relative organ weight, cecal microflora, serum cholesterol level and meat quality in broiler chickens. Journal of Poultry Science 52: 15-22.
LUNDBERG, I.E. (2003) Clinical symptoms in patients with myositis–an acquired metabolic myopathy? Current opinion in rheumatology 15: 675-678.
MACHIN, M., SIMOYI, M.F., BLEMINGS, K.P. and KLANDORF, H. (2004) Increased dietary protein elevates plasma uric acid and is associated with decreased oxidative stress in rapidly-growing broilers. Comparative Biochemistry & Physiology Part B Biochemistry & Molecular Biology 137: 383-390.
MERIJANIAN, A., COLASURDO, T., SAMTAK, P., ULLRICH, J. and SPAGNUOLO, J. (1980) The furanocoumarins of heracleum persicum. L. Revista Latinoamericana De Química 11: 51-53.
MOJAB, F., RUSTAIYAN, A.H. and JASBI, A.R. (2002) Essential oils of heracleum persicum desf.Ex fischer leaves. Daru Journal of Pharmaceutical Sciences 10: 6-8.
NAEINI, A., KHOSRAVI, A., CHITSAZ, M., SHOKRI, H. and KAMLNEJAD, M. (2009) Anti-candida albicans activity of some Iranian plants used in traditional medicine. Journal de Mycologie Médicale 19: 168-172.
NAEINI, A., SHOKRI, H. and KHOSRAVI, A.R. (2013a) Immunostimulatory effects of aqueous extract of heracleum persicum desf. On mouse peritoneal macrophages. Jundishapur Journal of Microbiology 6: 261-266.
NAEINI, A., SHOKRI, H. and KHOSRAVI, A.R. (2013b) Immunostimulatory effects of aqueous extract of heracleum persicum desf. On mouse peritoneal macrophages. Jundishapur Journal of Microbiology 6: 1-6.
NEHRU, P.A., SUNANDHADEVI, S., RAMA, T. and MUNIYAPPAN, N. (2017) Effect of probiotic supplementation on growth performance of crossbred calves in an organized cattle farm. Journal of Animal Health and Production 5 (3): 89-91.
NICKAVAR, B. and ABOLHASANI, F.A.-S. (2009) Screening of antioxidant properties of seven umbelliferae fruits from Iran. Pakistan Journal of Pharmaceutical Sciences 22: 30-35.
NORDBERG, J. and ARNÉR, E.S. (2005) Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radical Biology and Medicine 39: 1287.
ORAYAGA, K., OLUREMI, O. and ADENKOLA, A. (2016) Effect of water soaking of sweet orange (citrus sinensis) fruit peels on haematology, carcass yield and internal organs of finisher broiler chickens. Journal of Animal Health and Production 4: 65-71.
OWNAGH, A., FALLAHI, M., RAHMAN, B. and MOHAMMADZADEH, D. (2015) Effect of savory essential oil, garlic powder, and garlic aqueous extract on fungal load of poultry feed. Journal of Mycology Research 2: 23-30.
PANAHI, Y., DADJO, Y., PISHGOO, B., AKBARI, A. and SAHEBKAR, A. (2015) Clinical evaluation of the anti-inflammatory effects of heracleum persicum fruits. Comparative Clinical Pathology 24: 971-974.
PANAHI, Y., PISHGOO, B., BEIRAGHDAR, F., ARAGHI, Z.M., SAHEBKAR, A. and ABOLHASANI, E. (2011) Results of a randomized, open-label, clinical trial investigating the effects of supplementation with heracleum persicum extract as an adjunctive therapy for dyslipidemia. ScientificWorldJournal 11: 592-601.
POURAKBARI, M., SEIDAVI, A., ASADPOUR, L. and MARTÍNEZ, A. (2016) Probiotic level effects on growth performance, carcass traits, blood parameters, cecal microbiota, and immune response of broilers. Anais da Academia Brasileira de Ciências 88: 1011-1021.
RAZZAGHI-ABYANEH, M., SABERI, R., SHARIFAN, A., REZAEE, M.-B., SEIFILI, R., HOSSEINI, S.-I., SHAMS-GHAHFAROKHI, M., NIKKHAH, M., SABERI, I. and AMANI, A. (2013) Effects of heracleum persicum ethyl acetate extract on the growth, hyphal ultrastructure and aflatoxin biosynthesis in aspergillus parasiticus. Mycotoxin Research 29: 261-269.
RHEE, M.H., PARK, H.-J. and CHO, J.Y. (2009) Salicornia herbacea: Botanical, chemical and pharmacological review of halophyte marsh plant. Journal of Medicinal Plants Research 3: 548-555.
SAEED, M., ALAGAWANY, M., FAZLANI, S.A., KALHORO, S.A., NAVEED, M., ALI, N., ARAIN, M.A. and CHAO, S. (2019) Health promoting and pharmaceutical potential of ferulic acid for the poultry industry. World's Poultry Science Journal 75: 83-92, doi.org/10.1017/S0043933918000740.
SAYYAH, M., MOAIED, S. and KAMALINEJAD, M. (2005) Anticonvulsant activity of heracleum persicum seed. Journal of Ethnopharmacology 98: 209-211.
SEAL, B.S., LILLEHOJ, H.S., DONOVAN, D.M. and GAY, C.G. (2013) Alternatives to antibiotics: A symposium on the challenges and solutions for animal production. Animal Health Research Reviews 14: 78-87.
SEFIDKON, F., DABIRI, M. and MOHAMMAD, N. (2004) Analysis of the oil of heracleum persicum l. (seeds and stems). Journal of Essential Oil Research 16: 296-298.
SEFIDKON, F., JALILI, A. and MIRHAJI, T. (2002) Essential oil composition of three artemisia spp. From iran. Flavour and Fragrance Journal 17: 150-152.
SHAHRANI, M., NABAVIZADEH, F., SHIRZAD, H., YOUSEFI, H., MORADI, M.T. and MOGHADDASI, J. (2006) Effect of heracleum persicum extract on acid and pepsin secretion level in both basic and stimulated conditions with pentagastrin in rat. Social Psychiatry & Psychiatric Epidemiology 41: 911-917.
SHAMS-GHAHFAROKHI, M., SHOKOOHAMIRI, M.-R., AMIRRAJAB, N., MOGHADASI, B., GHAJARI, A., ZEINI, F., SADEGHI, G. and RAZZAGHI-ABYANEH, M. (2006) In vitro antifungal activities of allium cepa, allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes. Fitoterapia 77: 321-323.
SHARIFIFAR, F., POURNOURMOHAMMADI, S., ARABNEJAD, M., RASTEGARIANZADEH, R., RANJBARAN, O. and PURHEMMATY, A. (2010) Immunomodulatory activity of aqueous extract of heracleum persicum desf. In mice. Iranian Journal of Pharmaceutical Research 8: 287-292.
SHOKRZADEH, M. and SARAVI, S.S. (2010) The chemistry, pharmacology and clinical properties of sambucus ebulus: A review. Journal of Medicinal Plants Research 4: 095-103.
SOURI, E., FARSAM, H., SARKHEIL, P. and EBADI, F. (2004) Antioxidant activity of some furanocoumarins isolated from heracleum persicum. Pharmaceutical Biology 42: 396-399.
TAGHIZABET, N., MANGOLI, E., ANBARI, F., MASOODI, S.A., TALEBI, A.R. and MAZROOEI, M. (2016) The effect of heracleum persicum (golpar) oil and alcoholic extracts on sperm parameters and chromatin quality in mice. International Journal of Reproductive Biomedicine 14: 365.
TOLOUEE, M., ALINEZHAD, S., SABERI, R., ESLAMIFAR, A., ZAD, S.J., JAIMAND, K., TAEB, J., REZAEE, M.-B., KAWACHI, M. and SHAMS-GHAHFAROKHI, M. (2010) Effect of matricaria chamomilla l. Flower essential oil on the growth and ultrastructure of aspergillus niger van tieghem. International Journal of Food Microbiology 139: 127-133.
TOSUN, F., KıZıLAY, Ç.A., EROL, K., KıLıÇ, F.S., KÜRKÇÜOĞLU, M. and BAŞER, K.H.C. (2008) Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of heracleum crenatifolium. Food Chemistry 107: 990-993.
VIMAL, V. and DEVAKI, T. (2004) Linear furanocoumarin protects rat myocardium against lipidperoxidation and membrane damage during experimental myocardial injury. Biomedicine & Pharmacotherapy 58: 393-400.
YANG, L.-L., LIANG, Y.-C., CHANG, C.-W., LEE, W.-S., KUO, C.-T., WANG, C.-C., LEE, H.-M. and LIN, C.-H. (2002) Effects of sphondin, isolated from heracleum laciniatum, on il–1β-induced cyclooxygenase-2 expression in human pulmonary epithelial cells. Life Sciences 72: 199-213.
ZENG, Z., ZHANG, S., WANG, H. and PIAO, X. (2015) Essential oil and aromatic plants as feed additives in non-ruminant nutrition: A review. Journal of Animal Science and Biotechnology 6: 7.
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World's Poultry Science Journal
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