An area of a shrink-swell clay soil (Tunica clay, Vertic Haplaquept) with an established population of redvine, trumpetcreeper, honeyvine milkweed, redberry moonseed, and maypop passionflower was treated with dicamba once in the fall of 1983. The effect on perennial vines was determined for the following 4 yr in three rotational cropping systems involving winter wheat, soybean, corn, and sorghum, all with and without irrigation. Dicamba reduced the population of perennial vines 80% over 4 yr. Redvine and trumpetcreeper, the first and second most abundant species, were reduced by over 83 and 76%, respectively. Yield of soybean increased 17% in 1985 and 1987 while corn yield increased 9% in 1986 with dicamba use. In 1984 no effects on crop yield were measured. This inconsistent crop yield reponse after dicamba treatment, even though perennial vines were suppressed, must be considered in evaluating the economics of using dicamba for perennial vine control.