Treatments of dimethenamid-p at 0.7 kg ai/ha applied PRE in tank mixtures with EPTC (3.4 kg ai/ha), metribuzin (560 g ai/ha), pendimethalin (1.1 kg ai/ha), or rimsulfuron (26 g ai/ha) were compared with the same herbicides applied PRE alone in field efficacy trials in Idaho, Oregon, and Washington. Common lambsquarters, kochia, and redroot pigweed control was generally improved with dimethenamid-p tank mixtures compared with control by any herbicide applied alone except metribuzin. Hairy nightshade control at two locations was generally improved with tank mixtures compared with control by any herbicide applied alone. At Washington, where row spacing was narrower than at other locations, dimethenamid-p alone or in tank mixtures provided similar hairy nightshade control, and this control was greater than control by EPTC, metribuzin, or pendimethalin applied alone. ‘Alturas’, ‘Bannock Russet’, ‘Ranger Russet’, ‘Russet Burbank’, ‘Russet Norkotah’, and ‘Shepody’ potato tolerance to dimethenamid-p PRE at 0, 0.7, or 1.4 kg ai/ha was assessed in weed-free field trials conducted at Aberdeen, ID, in 2002 and 2003. Little or no crop injury was evident during the growing seasons and there were no reductions in U.S. No. 1 and total tuber yields regardless of dimethenamid-p rate or potato variety.