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Zuclopenthixol in adults with intellectual disabilities and aggressive behaviours: Discontinuation study

  • Frank Haessler (a1), Thomas Glaser (a2), Manfred Beneke (a2), Akos F. Pap (a2), Ralf Bodenschatz (a3) and Olaf Reis (a4)...

Summary

We investigated the effects of zuclopenthixol on aggressive behaviour in patients with intellectual disabilities by randomly withdrawing it after a 6-week period of open treatment. Of the 49 patients responding to the treatment, 39 took part in a randomised withdrawal trial. The placebo subgroup (n=20) showed more aggressive behaviour as indicated by outcomes observed by external raters on the Modified Overt Aggression Scale than did the continuing subgroup (n=19). The results indicate that discontinuation of zuclopenthixol in this population leads to an increase in aggressive behaviour.

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Corresponding author

Professor Dr Frank Haessler, Department of Child and Adolescent Psychiatry, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany. Email: frank.haessler@med.uni-rostock.de

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Declaration of interest

T.G., M.B. and A.F.P. are employees of Bayer Vital GmbH.

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References

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Yudofsky, S. C., Silver, J. M., Jackson, W. et al (1986) The Overt Aggression Scale for the objective rating of verbal and physical aggression. American Journal of Psychiatry, 143, 3539.

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Zuclopenthixol in adults with intellectual disabilities and aggressive behaviours: Discontinuation study

  • Frank Haessler (a1), Thomas Glaser (a2), Manfred Beneke (a2), Akos F. Pap (a2), Ralf Bodenschatz (a3) and Olaf Reis (a4)...
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