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Three Syndromes in Chronic Schizophrenia

Published online by Cambridge University Press:  06 August 2018

P.F. Liddle ,
Thomas R.E. Barnes ,
D. Morris  and
S. Haque
P.F. Liddle
Affiliation:
Charing Cross and Westminster Medical School, London (The Academic Unit, Horton Hospital, Epsom)
Thomas R.E. Barnes
Affiliation:
Charing Cross and Westminster Medical School, London; The Academic Unit Horton Hospital, Epsom
D. Morris
Affiliation:
Middlesex Hospital, London
S. Haque
Affiliation:
The Academic Unit, Horton Hospital, Epsom, Surrey
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Extract

In recent years, exploration of the distinction between positive and negative symptoms of schizophrenia has provided a fruitful basis for attempts to relate the clinical features of schizophrenia to the accumulating evidence of brain abnormalities in schizophrenic patients. By 1982, there was an extensive body of evidence supporting the hypothesis that negative schizophrenic symptoms, such as poverty of speech and flatness of affect, were associated with substantial brain abnormalities, such as increased ventricular to brain ratio, and extensive cognitive impairment (Crow, 1980; Andreasen & Olsen, 1982). However, at that stage there were several fundamental unanswered questions about the nature of negative symptoms, and their relationship to indices of brain abnormality. This paper presents some findings of a series of studies initiated in 1982 to seek answers to some of these questions.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 155 , Issue S7: Negative Symptoms in Schizophrenia , November 1989 , pp. 119 - 122
Copyright
Copyright © Royal College of Psychiatrists, 1989 

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