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Testosterone Therapy for Low Sexual Interest and Erectile Dysfunction in Men: a Controlled Study

  • Ronan O'Carroll (a1) and John Bancroft (a1)


A double blind cross-over comparison of testosterone and placebo injection was carried out in two groups of men with normal circulating testosterone levels, 10 complaining principally of loss of sexual interest and 10 complaining principally of erectile failure. A significant increase in sexual interest was produced by testosterone in the first group. There was no effect on erectile function in either group. These results support previous findings from hypogonadal men that testosterone influences sexual interest but not erectile function, and indicate that increasing plasma testosterone can effect sexual interest even in men with pre-treatment testosterone levels within the normal range.


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Anderson, D. C., Lesley, B. L., Fisher, R. A. Shepherd, J. H., Newman, L. & Hendrickx, A. G. (1976) Transplacental gradients of sex-hormone-binding-globulin in human and simian pregnancy. Clinical Endocrinology, 5, 657–69.
Bancroft, J., Tennent, T., Loucas, K. & Cass, J. (1974) Control of deviant sexual behaviour by drugs: behavioural effects of oestrogens and antiandrogens. British Journal of Psychiatry, 125, 310–5.
Bancroft, J. & Wu, F. C. (1983) Changes in erectile responsiveness during androgen replacement therapy. Archives of Sexual Behavior, 12, 5966.
Benkert, O., Witt, W., Adam, W. & Leitz, A. (1979) Effects of testosterone undecanoate on sexual potency and the hypothalamic-pituitary-gonadal axis of impotent males. Archives of Sexual Behavior, 8, 471–9.
Bruhl, E. E. & Leslie, C. H. (1963) Afrodex, double blind test in impotence. Medical Record and Annals, 56, 22–3.
Cooper, A. J. (1980) A clinical and endocrine study of mesterolone in secondary impotence. Journal of Psychosomatic Research, 24, 275–9.
Corker, C. S. & Davidson, D. W. (1978) A radioimmunoassay for testosterone in various biological fluids without chromatography. Journal of Steroid Biochemistry, 9, 373–4.
Davidson, J. M., Camargo, C. A. & Smith, E. R. (1979) Effects of androgens on sexual behaviour in hypogonadal men. Journal of Clinial Endocrinology and Metabolism, 48, 955–8.
Jakobovitz, T. (1970) The treatment of impotence with methyltestosterone thyroid. Fertility and Sterility, 21, 32–5.
Kwan, M., Greenleaf, W. J., Mann, J., Crapo, L. & Davidson, J. M. (1983) The nature of androgen action on male sexuality: a combined laboratory self report study on hypogonadal men. Journal of Clinical Endocrinology and Metabolism, 57, 557–62.
Luisi, M. & Franchi, F. (1980) Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients. Journal of Endocrinological Investigation, 3, 305–8.
Maxwell, C. (1978) Sensitivity and accuracy of the visual analogue scale: a psycho-physical classroom experiment. British Journal of Clinical Pharmacology, 6, 1524.
O'Carroll, R. E. (1983) The behavioural effects of androgens in men. Unpublished Ph.D. thesis, University of Edinburgh.
Salmimies, P., Kockott, G., Pirke, K. M., Vogt, H. J. & Schill, W. B. (1982) Effects of testosterone replacement on sexual behaviour in hypogonadal men. Archives of Sexual Behavior, 11, 345–53.
Schiavi, R. C. & White, D. (1974) Androgens and male sexual function. A review of human studies. Journal of Sex and Marital Therapy, 2, 214–28.
Skakkebaek, N., Bancroft, J., Davidson, D. & Warner, P. (1981) Androgen replacement with oral testosterone undecanoate in hypogonadal men: a double blind controlled study. Clinical Endocrinology, 14, 4961.
World Health Organisation: Task force on psychosocial research in family planning. (1982) Hormonal contraception for men: acceptability and effects on sexuality. Studies in Family Planning, 13, 328–42.
Wu, F. C., Bancroft, J., Davidson, D. W. & Nicol, K. (1982) The behavioural effects of testosterone undecanoate in adult Klinefelter men: a controlled study. Clinical Endocrinology, 16, 489–97.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Testosterone Therapy for Low Sexual Interest and Erectile Dysfunction in Men: a Controlled Study

  • Ronan O'Carroll (a1) and John Bancroft (a1)
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