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Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblings

  • Michael P. Harms (a1), Lei Wang (a2), Carolina Campanella (a1), Kristina Aldridge (a3), Amanda J. Moffitt (a3), John Kuelper (a1), J. Tilak Ratnanather (a4), Michael I. Miller (a4), Deanna M. Barch (a5) and John G. Csernansky (a6)...

Abstract

Background

The relatives of individuals with schizophrenia exhibit deficits of overall frontal lobe volume, consistent with a genetic contribution to these deficits.

Aims

To quantify the structure of gyral-defined subregions of prefrontal cortex in individuals with schizophrenia and their siblings.

Method

Grey matter volume, cortical thickness, and surface area of the superior, middle and inferior frontal gyri were measured in participants with schizophrenia and their unaffected (non-psychotic) siblings (n = 26 pairs), and controls and their siblings (n = 40 pairs).

Results

Grey matter volume was reduced in the middle and inferior frontal gyri of individuals with schizophrenia, relative to controls. However, only inferior frontal gyrus volume was also reduced in the unaffected siblings of those with schizophrenia, yielding a volume intermediate between their affected siblings and controls.

Conclusions

The structure of subregions of the prefrontal cortex may be differentially influenced by genetic factors in schizophrenia, with inferior frontal gyrus volume being most related to familial risk.

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Copyright

Corresponding author

Michael P. Harms, PhD, Department of Psychiatry (Box 8134), Washington University School of Medicine, 660 S. Euclid Ave, St Louis, MO 63110, USA. Email: mharms@conte.wustl.edu

Footnotes

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This work was supported by the National Institute of Mental Health (NIMH) (MH071616, MH056584) and the National Center for Research Resources (RR015241).

Declaration of interest

None.

Footnotes

References

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Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblings

  • Michael P. Harms (a1), Lei Wang (a2), Carolina Campanella (a1), Kristina Aldridge (a3), Amanda J. Moffitt (a3), John Kuelper (a1), J. Tilak Ratnanather (a4), Michael I. Miller (a4), Deanna M. Barch (a5) and John G. Csernansky (a6)...

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Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblings

  • Michael P. Harms (a1), Lei Wang (a2), Carolina Campanella (a1), Kristina Aldridge (a3), Amanda J. Moffitt (a3), John Kuelper (a1), J. Tilak Ratnanather (a4), Michael I. Miller (a4), Deanna M. Barch (a5) and John G. Csernansky (a6)...
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