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Sight and Insight: Brain Dopamine Receptor Occupancy by Neuroleptics Visualised in Living Schizophrenic Patients by Positron Emission Tomography

  • John L. Waddington (a1)

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There can be few more impressive sights in contemporary neuroscience and biological psychiatry than the imaging of neurotransmitter receptors in the brains of living human subjects by positron emission tomography (PET; Sedvall et al, 1986). How has such technology advanced our understanding of the pathophysiology and/or treatment of major psychiatric disorders?

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American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.
Crawley, J. C., Crow, T. J., Johnstone, E. C., et al (1986) Dopamine D-2 receptors in schizophrenia studied in vivo. Lancet, ii, 224225.
Crow, T. J. (1987) The dopamine hypothesis survives, but there must be a way ahead. British Journal of Psychiatry, 151, 460465.
Czudek, C. & Reynolds, G. P. (1988) Binding of 3H-SCH 23390 to post-mortem brain tissue in schizophrenia. British Journal of Pharmacology, 93 (Suppl.), 166P.
Dinan, T. G. (1987) Calcium-activated potassium conductance: an alternative to the dopamine hypothesis of neuroleptic action? British Journal of Psychiatry, 151, 445459.
Farde, L., Wiesel, F.-A., Hall, H., et al (1987a) No D-2 receptor increase in PET study of schizophrenia. Archives of General Psychiatry, 44, 671672.
Farde, L., Halldin, C., Stone-Elander, S., et al (1987b) PET analysis of human dopamine receptor subtypes using “C-SCH 23390 and 11C-raclopride. Psychopharmacology, 92, 278284.
Farde, L., Wiesel, F.-A., Halldin, C., et al (1988a) Central D-2 dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Archives of General Psychiatry, 45, 7176.
Farde, L., Pauli, S., Hall, H., et al (1988b) Stereoselective binding of 11C-raclopride in living human brain: a search for extrastriatal central D-2 dopamine receptors by PET. Psychopharmacology, 94, 471478.
Farde, L., Wiesel, F.-A., Jansson, P., et al (1988c) An open label trial of raclopride in acute schizophrenia: confirmation of D-2 dopamine receptor occupancy by PET. Psychopharmacology, 94, 17.
Hall, H., Farde, L. & Sedvall, G. (1988) Human dopamine receptor subtypes – in vitro binding analysis using 3H-SCH 23390 and 3H-raclopride. Journal of Neural Transmission, 73, 721.
Hess, E. J., Bracha, H. S., Kleinmann, J. E., et al (1987) Dopamine receptor subtype imbalance in schizophrenia. Life Sciences, 40, 14871497.
Iversen, L. L. (1987) Commentary on Dinan's hypothesis. British Journal of Psychiatry, 151, 459460.
Kane, J., Honigfeld, G., Singer, J., et al (1988) Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine. Archives of General Psychiatry, 45, 789796.
Köhler, C. & Radesäter, A. C. (1986) Autoradiographic visualisation of dopamine D-2 receptors in the monkey brain using the selective benzamide drug 3H-raclopride. Neuroscience Letters, 66, 8590.
McKenna, P. J. (1987) Pathology, phenomenology and the dopamine hypothesis of schizophrenia. British Journal of Psychiatry, 151, 288301.
O'Boyle, K. M., Molloy, A. G., Mashurano, M., et al (1986) Structural analogues of SCH 23390 as discriminators of dopamine receptor subtypes. Psychopharmacology Bulletin, 22, 599604.
O'Boyle, K. M., & Waddington, J. L. (1987) 3H-SCH 23390 binding to D-1 dopamine receptors in human brain. Biogenic Amines, 4, 365370.
Perlmutter, J. S., Kilbourn, M. R., Raichle, M. E., et al (1987) MPTP-induced up-regulation of in vivo dopaminergic radioligand binding in humans. Neurology, 37, 15751579.
Sedvall, G., Farde, L., Persson, A., et al (1986) Imaging of neurotransmitter receptors in the living human brain. Archives of General Psychiatry, 43, 9951005.
Seeman, P. (1987) Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse, 1, 133152.
Seeman, P., Farde, L., Sedvall, G., et al (1988) Brain dopamine receptors in schizophrenia: PET problems. Archives of General Psychiatry, 45, 598600.
Smith, M., Wolf, A. P., Brodie, J. D., et al (1988) Serial 18F-N-methyl-spiroperidol PET studies to measure changes in antipsychotic drug D-2 receptor occupancy in schizophrenic patients. Biological Psychiatry, 23, 653663.
Waddington, J. L. (1984) Tardive dyskinesia: a critical re-evaluation of the causal role of neuroleptics and of the dopamine receptor supersensitivity hypothesis. In Recent Research in Neurology (eds Callaghan, N. & Garvin, R.). London: Pitman.
Waddington, J. L. (1985) Further anomalies in the dopamine receptor supersensitivity hypothesis of tardive dyskinesia. Trends in Neurosciences, 8, 200.
Waddington, J. L. (1987) Tardive dyskinesia in schizophrenia and other disorders: associations with ageing, cognitive dysfunction and structural brain pathology in relation to neuroleptic exposure. Human Psychopharmacology, 2, 1122.
Waddington, J. L. (1988a) The ageing brain, neuroleptic drugs and the enigma of schizophrenia. Irish Journal of Medical Science, 157, 135141.
Waddington, J. L. (1988b) Therapeutic potential of selective D-l dopamine receptor agonists and antagonists in psychiatry and neurology. General Pharmacology, 19, 5560.
Waddington, J. L. & O'Boyle, K. M. (1987) The D-l dopamine receptor and the search for its functional role: from neurochemistry to behaviour. Reviews in the Neurosciences, 1, 157184.
Wong, D. F., Wagner, H. N., Tune, L. E., et al (1986) Positron emission tomography reveals elevated D-2 dopamine receptors in drug-naive schizophrenics. Science, 234, 15581563.
Wyatt, R. J., Alexander, R. C., Egan, M. F., et al (1988) Schizophrenia, just the facts: what do we know, how well do we know it? Schizophrenia Research, 1, 318.
Zeeberg, B. R., Gibson, R. E., Reba, R. C., et al (1988) Elevated D-2 dopamine receptors in drug-naive schizophrenics. Science, 239, 789791.

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Sight and Insight: Brain Dopamine Receptor Occupancy by Neuroleptics Visualised in Living Schizophrenic Patients by Positron Emission Tomography

  • John L. Waddington (a1)

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Sight and Insight: Brain Dopamine Receptor Occupancy by Neuroleptics Visualised in Living Schizophrenic Patients by Positron Emission Tomography

  • John L. Waddington (a1)
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