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Neuropsychological functioning in first-episode schizophrenia

  • Eugenia Kravariti (a1), Kevin Morgan (a2), Paul Fearon (a1), Jolanta W. Zanelli (a1), Julia M. Lappin (a1), Paola Dazzan (a1), Craig Morgan (a1), Gillian A. Doody (a3), Glynn Harrison (a4), Peter B. Jones (a5), Robin M. Murray (a6) and Abraham Reichenberg (a6)...

Abstract

Background

Identifying neurocognitive subtypes in schizophrenia may help establish neurobiologically meaningful subtypes of the disorder, but is frequently confounded by differences in intellectual function between individuals with schizophrenia and controls.

Aims

To examine neuropsychological performance in individuals with epidemiologically based, first-onset schizophrenia and intellectually matched controls.

Method

Using standard IQ and reading tests, we examined the proportions of 101 people with epidemiologically derived, first-onset schizophrenia/schizoaffective disorder and 317 community controls, falling into three a priori defined intellectual categories: ‘stable good’, ‘deteriorated poor’ and ‘stable poor’. Neuropsychological function was compared between intellectually matched participants with schizophrenia and control subgroups.

Results

Multiple deficits in executive function, processing speed and verbal memory, but not visual/spatial perception/memory, were detected in all participant groups with schizophrenia compared with controls. The average effect size across the affected domains ranged from small to medium to large in the stable good, deteriorated poor and stable poor subgroups of participants with schizophrenia, respectively.

Conclusions

Compared with intellectually matched controls, people with epidemiologically derived, first-onset schizophrenia/schizoaffective disorder show multiple deficits in executive function, processing speed and verbal memory.

Copyright

Corresponding author

Eugenia Kravariti, PhD, Department of Psychiatry, Box 58, NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. Email: e.kravariti@iop.kcl.ac.uk

Footnotes

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The study was funded by grants from the Medical Research Council, London, England, and the Stanley Medical Research Institute, Bethesda, Maryland, USA. Both funding organisations provided financial support for the conduct of study, collection, management and analysis of data.

Declaration of interest

None.

Footnotes

References

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Neuropsychological functioning in first-episode schizophrenia

  • Eugenia Kravariti (a1), Kevin Morgan (a2), Paul Fearon (a1), Jolanta W. Zanelli (a1), Julia M. Lappin (a1), Paola Dazzan (a1), Craig Morgan (a1), Gillian A. Doody (a3), Glynn Harrison (a4), Peter B. Jones (a5), Robin M. Murray (a6) and Abraham Reichenberg (a6)...
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