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The Maudsley Family Study 4. Normal planum temporale asymmetry in familial schizophrenia: A volumetric MRI study

  • S. Frangou (a1), T. Sharma (a2), T. Sigmundsson (a2), P. Barta (a3), G. Pearlson (a3) and R. M. Murray (a1)...

Abstract

Background

Loss or reversal of the normal asymmetry of the planum temporale (PT) has been reported in schizophrenia, and may be due to aberrations in the gene(s) controlling the development of brain asymmetries. We tested this hypothesis in a sample of schizophrenics and their relatives from families multiply affected with the disorder.

Method

We compared 32 schizophrenics and 55 of their non-schizophrenic first-degree relatives with 39 matched community controls. Volumetric measurements of the cortical volume beneath the PT were obtained using the Cavalieri method from three-dimensionally reconstructed magnetic resonance imaging images.

Results

PT volume asymmetry coefficients from patients and their relatives did not differ significantly from those of the controls. Gender-specific analysis did not reveal any differences.

Conclusions

Abnormalities in PT volume asymmetry are not present in familial schizophrenia, where genetic factors appear to predominate.

Copyright

Corresponding author

Dr S. Frangou, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF. Fax: 0171 701 9044

References

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The Maudsley Family Study 4. Normal planum temporale asymmetry in familial schizophrenia: A volumetric MRI study

  • S. Frangou (a1), T. Sharma (a2), T. Sigmundsson (a2), P. Barta (a3), G. Pearlson (a3) and R. M. Murray (a1)...

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The Maudsley Family Study 4. Normal planum temporale asymmetry in familial schizophrenia: A volumetric MRI study

  • S. Frangou (a1), T. Sharma (a2), T. Sigmundsson (a2), P. Barta (a3), G. Pearlson (a3) and R. M. Murray (a1)...
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