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Manifest disease and motor cortex reactivity in twins discordant for schizophrenia

  • Martin Schürmann (a1), Juha Järveläinen (a1), Sari Avikainen (a1), Tyrone D. Cannon (a2), Jouko Lönnqvist (a3), Matti Huttunen (a3) and Hari Riitta (a4)...

Summary

Schizophrenia is often associated with difficulties in distinguishing between actions of self and of others. This could reflect dysfunction of the mirror neuron system which directly matches observed and executed actions. We studied 11 people with schizophrenia and their co-twins without manifest disease, using stimulus-induced changes in the magnetoencephalographic $20 Hz rhythm as an index of activation in the motor cortex part of the mirror neuron system. During action observation and execution, motor cortex reaction was weaker in those with schizophrenia than in their co-twins, suggesting a disease-related dysfunction of motor cognition.

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Copyright

Corresponding author

Dr Martin Schürmann, School of Psychology, University of Nottingham, Nottingham NG7 2RD, UK. Email: martin.schuermann@nottingham.ac.uk

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Declaration of interest

None. Funding detailed in Acknowledgements.

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References

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Cannon, T. D., Huttunen, M. O., Lönnqvist, J., et al (2000) The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. American Journal of Human Genetics, 67, 369382.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Manifest disease and motor cortex reactivity in twins discordant for schizophrenia

  • Martin Schürmann (a1), Juha Järveläinen (a1), Sari Avikainen (a1), Tyrone D. Cannon (a2), Jouko Lönnqvist (a3), Matti Huttunen (a3) and Hari Riitta (a4)...
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