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Life Events, Depression and Hypothalamic–Pituitary–Adrenal Axis Function

  • R. J. Dolan (a1), S. P. Galloway (a2), P. Fonagy, F. V. A. De Souza (a3) and A. Wakeling (a3)...


The relationship between antecedent life events, clinical profile, and hypothalamic–pituitary–adrenal function was examined in 72 depressed patients. Antecedent life events were associated with first episodes of depression and with greater severity of illness, but their presence did not distinguish between patients diagnosed as endogenous or neurotic, and status on the dexamethasone suppression test was not associated with a greater or lesser likelihood of antecedent events. However, urinary free Cortisol levels were higher in those patients with life events and difficulties.


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Bebbingiton, F. E., Tennant, C. & Hurry, J. (1981) Adversity and the nature of psychiatric disorder in the community. Journal of Affective Disorders, 3, 345366.
Brown, G. W. & Harris, T. (1978) Social Origins of Depression. London: Tavistock.
Brown, M. B. & Forsythe, A. B. (1974) The small sample behaviour of some statistics which test the equality of several means. Technometrics., 16, 129132.
Brown, M. B. Ni Brolchain, M. & Harris, R. D. (1979) Psychotic and neurotic depression: aetiological and background factors. Journal of Affective Disorder, 1, 195211.
Calloway, S. P., Dolan, R. J., Fonagy, P., De Souza, F. V. A. & Wakeling, A. (1984) Endocrine changes and clinical profiles in depression: i. The dexamethasone suppression test. Psychological Medicine, 14, 749758.
Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry, 111, 659674.
Carroll, B. J. (1982) The dexamethasone suppression test for melancholia. British Journal of Psychiatry, 140, 292304.
Carroll, B. J. Curtis, G. C. & Mendels, C. (1976) Neuroendocrine regulation in depression. Archives of General Psychiatry, 33, 10511057.
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 5662.
Heron, M. J. (1965) A note on the concept endogenous-exogenous. British Journal of Medical Psychology, 38, 241245.
Holden, N. L. (1983) Depression and the Newcastle scale: their relationship to the dexamethasone suppression test. British Journal of Psychiatry, 142, 505507.
Leff, M. J., Roatch, J. F. & Bunney, W. E. (1970) Environmental factors preceding the onset of severe depression. Psychiatry, 33, 293311.
Lloyd, C. (1980) Life events and depressive disorder reviewed: 11. Events as precipitating factors. Archives of General Psychiatry, 37, 541548.
Mason, J. W. (1968) A review of psychoendocrine research on the pituitary-adrenal-cortical system. Psychosomatic Medicine, 30, Suppl. 576607.
Miller, P. A. & Ingham, J. (1976) Friends, confidants and symptoms. Social Psychiatry, 11, 5158.
Paykel, E. S. (1974) Recent life events and clinical depression. In Life Stress and Illness (eds. Gunderson, E. K. E. and Rahe, R. H.). Springfield, Illinois: Thomas.
Sachar, E. J. (1967) Corticosteroids in depressive illness. A longitudinal psychoendocrine study. Archives of General Psychiatry, 17, 554567.
Spitzer, R. L., Endicott, & Robins, E. (1978) Research diagnostic criteria: rationality and reliability. Archives of General Psychiatry, 35, 773782.
Thompson, K. C. & Hendrie, H. C. (1972) Environmental stress in primary depressive illness. Archives of General Psychiatry, 26, 130132.
Traskman, L., Tybing, G., Asberg, M., Bertilssen, L., Lanto, O. & Schalling, D. (1980) Cortisol in the CSF of depressed and suicidal patients. Archives of General Psychiatry, 37, 761767.
Wing, J. D., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
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Life Events, Depression and Hypothalamic–Pituitary–Adrenal Axis Function

  • R. J. Dolan (a1), S. P. Galloway (a2), P. Fonagy, F. V. A. De Souza (a3) and A. Wakeling (a3)...
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