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Is Mania Incompatible with Down's Syndrome?

  • Robert Sovner (a1), Anne Desnoyers Hurley (a2) and Richard Labrie (a3)


In reviewing the medical literature on the association between affective illness and mental retardation (Sovner & Hurley, 1983), we were intrigued to find that, although there were many cases of major depression and depressive neurosis among people with Down's syndrome, there were no reports of mania in such individuals. This finding provoked us to pursue the hypothesis that Down's syndrome may preclude the development of mania.


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Baldessarini, R. J. (1981) A summary of biomedical aspects of mood disorders. McLean Hospital Journal, 6, 134.
Breese, G. R., Mueller, R. A. & Lipton, M. A. (1978) Developmental neuropsychopharmacology. In Psychopharmacology: A Generation of Progress (ed. Lipton, M. A., DiMascio, A., Killam, K. F.). New York: Raven Press.
Cochrane, W. E., Sran, P. K. & Varano, G. A. (1977) The relocation syndrome in mentally retarded individuals. Mental Retardation, 15, 10–2.
Dàvies, T. S. (1959) “Niamid” in monogolism. British Journal of Medicine, 2, 1098.
Diagnostic and Statistical Manual of Mental Illness, Third Edition (1980). Washington, D.C.: American Psychiatric Association.
Duché, D. J. & Lécuyer, R. (1967) A propos des états psychoneurotiques observés chez des mongoliens. Revue de Neuropsychiatrie Infantile, 15, 349–58.
Egeland, J. A. & Hostetter, A. M. (1983) Amish study I. Affective disorders among the Amish, 1976–1980. American Journal of Psvchiatry, 140, 5661.
Fox, R., Karan, O. C. & Rotator, A. F. (1981) Regression including anorexia in a Down's syndrome adult: a seven year followup. Journal of Behaviour Therapy and Experimental Psychiatry, 12, 351–4.
Jakab, I. (1978) Basal ganglia calcification and psychosis in mongolism. European Neurology, 17, 300–14.
Keegan, D. L., Pettigrew, A. & Parker, Z. (1974) Psychosis in Down's syndrome treated with amitriptyline. Canadian Medical Association Journal, 110, 1128–9.
Mann, D. M. A., Lincoln, H., Yates, P. O. & Brennan, C. M. (1980) Monoamine metabolism in Down's syndrome. Lancet, 2, 1366–7.
Rorth, A. I. (1961) Psychotic depression in a mongol. Journal of Mental Subnormality, 7, 45–7.
Satten, N. R. & Singer, (1979) Successful treatment in a woman with Down's syndrome. Psychiatric Opinion, 16, 3640.
Sovner, R. & Hurley, A. D. (1983) Do the mentally retarded suffer from affective illness? Archives of General Psychiatry, 40, 61–7.

Is Mania Incompatible with Down's Syndrome?

  • Robert Sovner (a1), Anne Desnoyers Hurley (a2) and Richard Labrie (a3)


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Is Mania Incompatible with Down's Syndrome?

  • Robert Sovner (a1), Anne Desnoyers Hurley (a2) and Richard Labrie (a3)
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