Hostname: page-component-8448b6f56d-c47g7 Total loading time: 0 Render date: 2024-04-23T13:13:18.797Z Has data issue: false hasContentIssue false
  • English
  • Français

Is Mania Incompatible with Down's Syndrome?

Published online by Cambridge University Press:  29 January 2018

Robert Sovner ,
Anne Desnoyers Hurley  and
Richard Labrie
Robert Sovner*
Affiliation:
Drug Intake Management and Evaluation System, Inc., 71 Elton Avenue, Watertown, Massachusetts 02172, U.S.A.
Anne Desnoyers Hurley
Affiliation:
Department of Psychology, Massachusetts Hospital School, Canton, Massachusetts, U.S.A.
Richard Labrie
Affiliation:
Drug Intake Management and Evaluation System, Inc.
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Extract

In reviewing the medical literature on the association between affective illness and mental retardation (Sovner & Hurley, 1983), we were intrigued to find that, although there were many cases of major depression and depressive neurosis among people with Down's syndrome, there were no reports of mania in such individuals. This finding provoked us to pursue the hypothesis that Down's syndrome may preclude the development of mania.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 146 , Issue 3 , March 1985 , pp. 319 - 320
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baldessarini, R. J. (1981) A summary of biomedical aspects of mood disorders. McLean Hospital Journal, 6, 1–34.Google Scholar
Breese, G. R., Mueller, R. A. & Lipton, M. A. (1978) Developmental neuropsychopharmacology. In Psychopharmacology: A Generation of Progress (ed. Lipton, M. A., DiMascio, A., Killam, K. F.). New York: Raven Press.Google Scholar
Cochrane, W. E., Sran, P. K. & Varano, G. A. (1977) The relocation syndrome in mentally retarded individuals. Mental Retardation, 15, 10–2.Google Scholar
Dàvies, T. S. (1959) “Niamid” in monogolism. British Journal of Medicine, 2, 1098.Google Scholar
Diagnostic and Statistical Manual of Mental Illness, Third Edition (1980). Washington, D.C.: American Psychiatric Association.Google Scholar
Duché, D. J. & Lécuyer, R. (1967) A propos des états psychoneurotiques observés chez des mongoliens. Revue de Neuropsychiatrie Infantile, 15, 349–58.Google Scholar
Egeland, J. A. & Hostetter, A. M. (1983) Amish study I. Affective disorders among the Amish, 1976–1980. American Journal of Psvchiatry, 140, 56–61.Google Scholar
Fox, R., Karan, O. C. & Rotator, A. F. (1981) Regression including anorexia in a Down's syndrome adult: a seven year followup. Journal of Behaviour Therapy and Experimental Psychiatry, 12, 351–4.Google Scholar
Jakab, I. (1978) Basal ganglia calcification and psychosis in mongolism. European Neurology, 17, 300–14.Google Scholar
Keegan, D. L., Pettigrew, A. & Parker, Z. (1974) Psychosis in Down's syndrome treated with amitriptyline. Canadian Medical Association Journal, 110, 1128–9.Google ScholarPubMed
Mann, D. M. A., Lincoln, H., Yates, P. O. & Brennan, C. M. (1980) Monoamine metabolism in Down's syndrome. Lancet, 2, 1366–7.Google Scholar
Rorth, A. I. (1961) Psychotic depression in a mongol. Journal of Mental Subnormality, 7, 45–7.Google Scholar
Satten, N. R. & Singer, (1979) Successful treatment in a woman with Down's syndrome. Psychiatric Opinion, 16, 36–40.Google Scholar
Sovner, R. & Hurley, A. D. (1983) Do the mentally retarded suffer from affective illness? Archives of General Psychiatry, 40, 61–7.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.