Skip to main content Accessibility help
×
Home

In Vivo Magnetic Resonance Spectroscopy: Applications in Psychiatry

  • Michael Maier (a1)

Abstract

Background

Nuclear magnetic resonance is a non-destructive and non-invasive technology that is highly suited for research in psychiatry. It is establishing itself as a versatile means of studying brain morphology, chemistry and function and is finding a place in the diagnosis of disease, monitoring of treatment and the study of basic brain processes.

Method

A literature review was undertaken.

Results

Magnetic resonance spectroscopy has been shown to distinguish between psychiatric disorders, and has provided evidence of their pathophysiological mechanisms.

Conclusions

Spectroscopy in particular opens a window, for the first time, on the study of in vivo brain chemistry.

Copyright

References

Hide All
Arnold, D. L. (1992) Reversible reduction of NAA after acute central nervous system damage. Society of Magnetic Resonance in Medicine (Book of Abstracts), 1, 643.
Austin, S. J., Connelly, A., Gadian, D. C., et al (1991) Localized 1H NMR spectroscopy in Canavan's disease: a report of two cases. Magnetic Resonance in Medicine, 19, 439445.
Bartels, M., Gunther, U., Albert, K., et al (1991) 19F nuclear magnetic resonance spectroscopy of neuroleptics: the first in vivo pharmacokinetics of trifluoperazine in the rat brain and the first in vivo spectrum of fluphenazine in the human brain. Biological Psychiatry, 30, 656662.
Birken, D. L. & Oldendorf, W. H. (1989) N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H NMR spectroscopic studies of brain. Neuroscience and Biobehavioural Reviews, 13, 2331.
Breiter, S. N., Arroyo, S., Mathews, V. P., et al (1994) Proton MR spectroscopy in patients with seizure disorders. American Journal of Neuroradiology, 15, 373384.
Brown, G. G., Levine, S. R., Gorell, J. M., et al (1989) in vivo 31P NMR profiles of Alzheimer's disease and multiple subcortical infarct dementia. Neurology, 39, 14231427.
Brown, T. R., Kincaid, B. M. & Ugurbil, K. (1982) NMR chemical shift imaging in three dimensions. Proceedings of the National Academy of Science, USA, 79, 35233526.
Bruhn, H., Frahm, J., Gyngell, M. L., et al (1989) Cerebral metabolism in man after acute stroke: new observations using localized proton NMR spectroscopy. Magnetic Resonance in Medicine, 9, 126131.
Bruhn, H., Weber, T., Thorwirth, V., et al (1991) In vivo monitoring of neuronal loss in Creutzfeldt–Jakob disease by proton magnetic resonance spectroscopy. Lancet, 337, 16101611.
Calabrese, G., de Icken, R. F., Fein, G., et al (1992) 31Phosphorus magnetic resonance spectroscopy of the temporal lobes in schizophrenia. Biological Psychiatry, 32, 2632.
Christiansen, P., Toft, P., Larsson, H. B. W., et al (1993) The concentration of N acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium. Magnetic Resonance Imaging, 11, 799806.
Dager, S. R., Marro, K. I., Richards, T. L., et al (1994) Preliminary application of magnetic resonance spectroscopy to investigate lactate-induced panic. American Journal of Psychiatry, 151, 5763.
Davie, C. A., Hawkins, C. P., Barker, G. J., et al (1994a) Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain, 117, 4959.
Davie, C. A., Barker, G. J., Quinn, N., et al (1994b) Proton MRS in Huntington's disease. Lancet, 343, 1580.
Fisher, M., Sotak, C. H., Minematsu, K., et al (1992) New magnetic resonance techniques for evaluating cerebrovascular disease. Annals of Neurology, 32, 115122.
Gill, S. S., Thomas, D. G. T., Van Bruggen, N., et al (1990) Proton MR spectroscopy of intracranial tumours: in vivo and in vitro studies. Journal of Computer Assisted Tomography, 14, 497504.
Graham, S. H., Meyerhoff, D. J., Bayne, L., et al (1994) Magnetic resonance spectroscopy of N-acetylaspartate in hypoxicischaemic encephalopathy. Annals of Neurology, 35, 490494.
Hanstock, C. C., Rothman, D. L., Prichard, J. W., et al (1988) Spatially localized 1H NMR spectra of metabolites in the human brain. Proceedings of the National Academy of Science, USA, 85, 18211825.
Kato, T., Takahashi, S. & Inubushi, T. (1991) Brain lithium concentration by 7Li and 1H magnetic resonance spectroscopy in bipolar disorder. Psychiatry Research: Neuroimaging, 45, 5363.
Kato, T., Takahashi, S. Shiori, T., et al (1992) Brain phosphorous metabolism in depressive disorders detected by phosphorous 31 magnetic resonance spectroscopy. Journal of Affective Disorder, 26, 223230.
Keshavan, M. S., Kapur, S. & Pettegrew, J. W. (1991a) Magnetic resonance spectroscopy in psychiatry: potential, pitfalls and promise. American Journal of Psychiatry, 148, 976985.
Keshavan, M. S., Pettegrew, J. W. & Panchalingam, K. S. (1991b) Phosphorus 31 magnetic resonance spectroscopy detects altered brain metabolism before onset of schizophrenia. Archives of General Psychiatry, 48, 1112.
Keshavan, M. S., Sanders, R. D., Pettegrew, J. W., et al (1993) Frontal lobe metabolism and cerebral morphology in schizophrenia: 31P MRS and MRI studies. Schizophrenia Research, 10, 241246.
Komoroski, R. A., Newton, J. E. O., Karson, C., et al (1990) Detection of psychoactive drugs in vivo in humans using 19F NMR spectroscopy. Biological Psychiatry, 29, 711714.
Maier, M., Ron, M. A., Barker, G. J., et al (1995) Proton magnetic resonance spectroscopy: an in vivo method of detecting hippocampal neuronal loss in schizophrenia. Psychological Medicine, in press.
Meyeroff, D. J., Mackay, S., Poole, N., et al (1994) N acetylaspartate reductions measured by 1H MRS in cognitively impaired HIV-seropositive individuals. Magnetic Resonance Imaging, 12, 653659.
Michaelis, T., Merboldt, K. D., Bruhn, H., et al (1993) Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Neuroradiology, 187, 219227.
Miller, B. L. (1991) A review of chemical issues in 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine and choline. NMR in Biochemistry, 4, 4752.
Miller, B. L. Moats, R. A., Shonk, T., et al (1993) Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy. Radiology, 187, 433437.
Miller, D. H., Austin, S. J., Connelly, A., et al (1991) Proton magnetic resonance spectroscopy of an acute and chronic lesion in multiple sclerosis. Lancet, 337, 5859.
Minshew, N. J., Goldstein, G., Dombrowski, S. M., et al (1993) A preliminary 31P MRS study of autism: evidence for undersynthesis and increased degradation of brain membranes. Biological Psychiatry, 33, 762773.
Murata, T., Koshino, Y., Omori, M., et al (1993) In vivo proton magnetic resonance spectroscopy study in premature aging in adult Down's syndrome. Biological Psychiatry, 34, 290297.
Murphy, D. G. M., Bottomley, P. A., Salerno, J. A., et al (1993) An in vivo study of phosphorus and glucose metabolism in Alzheimer's disease using magnetic resonance spectroscopy and PET. Archives of General Psychiatry, 50, 341349.
Nasrallah, H. A., Skinner, T. E., Schmalbrook, P., et al (1994) Proton magnetic resonance spectroscopy (1H MRS) of the hippocampal formation in schizophrenia: a pilot study. British Journal of Psychiatry, 165, 481485.
Petroff, O. A. C., Prichard, J. W., Behar, K. L., et al (1985) Cerebral intracellular pH by 31P nuclear resonance spectroscopy. Neurology, 35, 781788.
Pettegrew, J. W., Withers, G., Panchalingam, K., et al (1988a) Considerations for brain pH assessment by 31P NMR. Magnetic Resonance Imaging, 6, 135142.
Pettegrew, J. W., Moossy, J., Withers, G., et al (1988b) 31P nuclear magnetic resonance study of the brain in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology, 47, 235248.
Pettegrew, J. W., Panchalingam, K., Moossy, J., et al (1988c) Correlation of 31P magnetic resonance spectroscopy and morphological findings in Alzheimer's disease. Archives of Neurology, 45, 10931096.
Pettegrew, J. W., Keshavan, M. S., Panchalingam, K., et al (1991) Alterations in brain high energy phosphate and membrane phospholipid metabolism in first episode, drug naive schizophrenics: a pilot study of dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Archives of General Psychiatry, 48, 563568.
Rothman, D. L., Houseman, A. M., Graham, G. D., et al (1991) Localized proton NMR observation of [3-13C] lactate in stroke after [1-13C] glucose infusion. Magnetic Resonance in Medicine, 21, 302307.
Rothman, D. L., Novotny, E. J., Shulman, G. I., et al (1992) 1H-[13C] NMR measurements of [4-13C] glutamate turnover in human brain. Proceedings of the National Academy of Science, USA, 89, 96039606.
Shulman, R. G., Blamire, A. M., Rothman, D. L., et al (1993) Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proceedings of the National Academy of Science, USA, 90, 31273133.
Toft, P. B., Christiansen, P., Pryds, O., et al (1994) T1, T2, and concentrations of brain metabolites in neonates and adolescents estimated with H-1 MR spectroscopy. Journal of Magnetic Resonance Imaging, 4, 15.
Vion-Dury, J., Meyerhoff, D. J., Cozzone, P. J., et al (1994) What might be the impact of neurology of the analysis of brain metabolism by in vivo magnetic resonance spectroscopy? Journal of Neurology, 241, 354371.

In Vivo Magnetic Resonance Spectroscopy: Applications in Psychiatry

  • Michael Maier (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

In Vivo Magnetic Resonance Spectroscopy: Applications in Psychiatry

  • Michael Maier (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *