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Implementing magnetic resonance imaging into clinical routine screening in patients with psychosis?

  • Stefan Borgwardt (a1) and André Schmidt (a2)

Summary

In this issue, Falkenberg et al explore the practicability of magnetic resonance imaging (MRI) as part of the initial clinical assessment in patients with first-episode psychosis and the prevalence, nature and clinical significance of radiological abnormalities in these patients. They provide evidence for the use of MRI data to detect gross brain abnormalities. In addition, improvements in quantitative analyses makes MRI an indispensable tool to elucidate the neurobiological substrates that might underlie primary (or idiopathic) psychotic illness.

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Copyright

Corresponding author

Stefan Borgwardt, University of Basel, Department of Psychiatry (UPK), Wilhelm Klein Strasse 27, 4012 Basel, Switzerland. Email: Stefan.borgwardt@upkbs.ch

Footnotes

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See pp. 231–237, this issue.

Declaration of interest

None.

Footnotes

References

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1 Keshavan, MS, Kaneko, Y. Secondary psychoses: an update. World Psychiatry 2013; 12: 415.
2 Lubman, DI, Velakoulis, D, McGorry, PD, Smith, DJ, Brewer, W, Stuart, G, et al. Incidental radiological findings on brain magnetic resonance imaging in first-episode psychosis and chronic schizophrenia. Acta Psychiatr Scand 2002; 106: 331–6.
3 Khandanpour, N, Hoggard, N, Connolly, DJ. The role of MRI and CT of the brain in first episodes of psychosis. Clin Radiol 2013; 68: 245–50.
4 Albon, E, Tsourapas, A, Frew, E, Davenport, C, Oyebode, F, Bayliss, S, et al. Structural neuroimaging in psychosis: a systematic review and economic evaluation. Health Technol Assess 2008; 12: iiiiv, ix–163.
5 National Institute for Health and Clinical Excellence (2008). Structural Neuroimaging in First-Episode Psychosis. NICE guideline (TA 136).
6 Sommer, IE, de Kort, GA, Meijering, AL, Dazzan, P, Hulshoff Pol, HE, Kahn, RS, et al. How frequent are radiological abnormalities in patients with psychosis? A review of 1379 MRI scans. Schizophr Bull 2013; 39: 815–9.
7 Falkenberg, I, Benetti, S, Raffin, M, Wuyts, P, Pettersson-Yeo, W, Dazzan, P, et al. Clinical utility of magnetic resonance imaging in first-episode psychosis. Br J Psychiatry 2017; 211: 231–7.
8 Lieberman, J, Bogerts, B, Degreef, G, Ashtari, M, Lantos, G, Alvir, J. Qualitative assessment of brain morphology in acute and chronic schizophrenia. Am J Psychiatry 1992; 149: 784–94.
9 Lawrie, SM, Abukmeil, SS, Chiswick, A, Egan, V, Santosh, CG, Best, JJ. Qualitative cerebral morphology in schizophrenia: a magnetic resonance imaging study and systematic literature review. Schizophr Res 1997; 25: 155–66.
10 Borgwardt, SJ, Radue, EW, Götz, K, Aston, J, Drewe, M, Gschwandtner, U, et al. Radiological findings in individuals at high risk of psychosis. J Neurol Neurosurg Psychiatry 2006; 77: 229–33.

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Implementing magnetic resonance imaging into clinical routine screening in patients with psychosis?

  • Stefan Borgwardt (a1) and André Schmidt (a2)
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