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Hypothalamic-pituitary-adrenal axis response in borderline personality disorder without post-traumatic features

  • Jose L. Carrasco (a1), Marina Díaz-Marsá (a1), Jose I. Pastrana (a1), Rosa Molina (a1), Loreto Brotons (a1), María I. López-Ibor (a1) and Juan J. López-Ibor (a2)...

Summary

Hypothalamic–pituitary–adrenal (HPA) axis sensitivity was investigated in 32 non-medicated patients with borderline personality disorder without comorbid post-traumatic syndromes and in 18 normal individuals using a modified dexamethasone suppression test (0.25 mg). Enhanced cortisol suppression was found in the patients v. controls (P < 0.05) and the percentage of participant's with non-suppression was smaller in the patient (34%) than in the control group (89%) (P < 0.01). Baseline cortisol levels in the patients were also lower than in the controls (P < 0.05). The 0.25 mg dexamethasone suppression test reveals increased feedback inhibition of the HPA in borderline personality disorder.

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Copyright

Corresponding author

Jose L. Carrasco, MD, Department of Psychiatry, Hospital Clínico San Carlos. c/ Martin Lagos s/n, 28040 Madrid, Spain. Email: jcarrasco.hcsc@salud.madrid.org

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Declaration of interest

None.

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References

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Hypothalamic-pituitary-adrenal axis response in borderline personality disorder without post-traumatic features

  • Jose L. Carrasco (a1), Marina Díaz-Marsá (a1), Jose I. Pastrana (a1), Rosa Molina (a1), Loreto Brotons (a1), María I. López-Ibor (a1) and Juan J. López-Ibor (a2)...
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