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Human Leucocyte Antigens and Tardive Dyskinesia

Published online by Cambridge University Press:  02 January 2018

K. W. Brown
Affiliation:
Royal Edinburgh Hospital
T. White*
Affiliation:
The Douglas Inch Clinic, 2 Woodside Terrace, Glasgow G3 7UY
*
Correspondence

Abstract

HLA status was asessed in matched groups of schizophrenics, 20 with and 20 without tardive dyskinesia. The antigen frequencies were also compared with that in a control sample. The anticipated excess of HLA-B44 was not confirmed. Pooled data displayed a shortfall of HLA-Cw7 and an excess of HLA-B44 in schizophrenics relative to population controls.

Type
Brief Reports
Copyright
Copyright © Royal College of Psychiatrists, 1991 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Barnes, T. R. E. (1988) Tardive dyskinesia: risk factors, pathophysiology and treatment. In Recent Advances in Clinical Psychiatry No. 6 (eds Granville-Grossman, K. & Wing, P.). Edinburgh: Churchill Livingstone.Google Scholar
Blackwelder, E. C. Mittal, K. K. McNamara, P. M. et al (1982) Lack of association between HLA and age in an ageing population. Tissue Antigens, 20, 188192.Google Scholar
Canoso, R. T. Lewis, M. E. & Yunis, E. J. (1982) Association of HLA-B44 with chlorpromazine-induced antibodies. Clinical Immunology and Immunopathology, 5, 272282.Google Scholar
Canoso, R. T. Romero, J. A. & Yunis, E. J. (1986) Immuno-genetic markers of chlorpromazine-induced tardive dyskinesia. Journal of Neuro-Immunology, 12, 247252.Google Scholar
Davis, J. M. (1976) Comparitive dose and cost of antipsychotic medication. Archives of General Psychiatry, 33, 858861.Google Scholar
Edwards, J. H. (1974) HLA and disease. The detection of associations. Journal of Immuno-Genetics, 1, 249258.Google Scholar
Haldane, J. B. S. (1955) The estimation and significance of the logarithm of a ratio of frequencies. Annals of Human Genetics, 20, 309311.Google Scholar
Kane, J. M. & Smith, J. M. (1982) Tardive dyskinesia: prevalence and risk factors 1959–1979. Archives of General Psychiatry, 39, 437481.Google Scholar
McGuffin, P. & Sturt, E. (1986) Genetic markers in schizophrenia. Human Heredity, 36, 6588.Google Scholar
National Institute of Mental Health (1976) Abnormal Involuntary Movement Scale. In Early Clinical Drug Evaluation Unit Assessment Manual (ed. Guy, W.). Rockville, MD: US Department of Health & Human Services.Google Scholar
Schooler, N. R. & Kane, J. M. (1982) Research diagnosis of tardive dyskinesia. Archives of General Psychiatry, 39, 686687.Google ScholarPubMed
Simpson, G. M. Lee, J. W. Zobek, B. et al (1979) A rating scale for tardive dyskinesia. Psychopharmacology, 64, 171179.Google Scholar
Teresaki, P. I. (1970) Techniques in HLA typing. In Manual of Tissue Typing Techniques (eds Brand, D. L. & Rae Jnr, J. G.). Bethesda, National Institute of Health.Google Scholar
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