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HLA Antigens in Schizophrenia: A Family Study

Published online by Cambridge University Press:  29 January 2018

R. Chadda ,
P. Kulhara ,
T. Singh  and
S. Sehgal
R. Chadda
Affiliation:
Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
P. Kulhara*
Affiliation:
Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
T. Singh
Affiliation:
Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
S. Sehgal
Affiliation:
Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
*
∗ Correspondence
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Extract

HLA haplotypes A and B were studied in eight familes with two or more schizophrenic members. All index cases and all but two sick relatives satisfied Research Diagnostic Criteria for the diagnosis of schizophrenia; 45 subjects were studied. Data were analysed by sequential tests for the detection of linkage and by the affected sib-pair method. The results do not support a linkage between HLA and schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 149 , Issue 5 , November 1986 , pp. 612 - 615
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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References

Cazzullo, C. L., Smer Aldi, E. & Penati, G. (1974) The leucocyte antigen system H LA as a possible genetic marker of schizophrenia. British Journal of Psychiatry, 125, 25–27.Google Scholar
Crowe, R. R., Thompson, J. S., Flink, R. & Weinberger, N. (1979) HLA antigens and schizophrenia. Archives of General Psychiatry, 36, 231–233.Google Scholar
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.CrossRefGoogle ScholarPubMed
Gottesman, I.I. & Shields, J. (1982) Schizophrenia: The Epigenetic Puzzle. Cambridge: Cambridge University Press.Google Scholar
Green, J. R. & Woodrow, J. C. (1977) Sibling method for detecting HLA-linked genes in disease. Tissue Antigens, 9, 31–35.CrossRefGoogle ScholarPubMed
Heston, L. L. (1966) Psychiatric disorders in foster home reared children of schizophrenic mothers. British Journal of Psychiatry, 112, 819–825.CrossRefGoogle ScholarPubMed
Ivanyi, P., Droes, J., Schreuder, G. M., D'Amaro, J. & Van Rood, J. J. (1983) A search for association of HLA antigens with paranoid schizophrenia: A, appears as a possible marker. Tissue Antigens, 22, 186–193.Google Scholar
Kety, S. S., Rosenthal, D., Wender, P. H. & Schulsinger, F. (1968) The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. In The Transmission of Schizophrenia (eds D. Rosenthal and S. S. Kety). Oxford: Pergamon.Google Scholar
Khouri, P. J., Haier, R. J., Reider, R. O. & Rosenthal, D. (1980) A symptom schedule for the diagnosis of borderline schizophrenia. British Journal of Psychiatry, 137, 145–147.Google Scholar
Lidz, T., Blatt, S. & Cook, B. (1981) Critique of the Danish-American studies of adopted-away offspring of schizophrenic parents. American Journal of Psychiatry, 138, 1063–1068.Google ScholarPubMed
Lowing, P. A., Mirsky, A. F., & Pereira, R. (1983) The inheritance of schizophrenia-spectrum disorders-a reanalysis of the Danish adopted study data. American Journal of Psychiatry, 140, 1167–1171.Google ScholarPubMed
McGuffin, P., Farmer, A. E. & Yonace, A. H. (1981) HLA antigens and subtypes of schizophrenia. Psychiatry Research, 5, 115–122.CrossRefGoogle ScholarPubMed
McGuffin, P., Festenstein, H. & Murray, R. (1983) A family study of HLA antigens and other genetic markers in schizophrenia. Psychological Medicine, 13, 31–43.Google Scholar
Miyanaga, K., Machiyama, Y. & Juji, T. (1984) Schizophrenic disorders and HLA-DR antigens. Biological Psychiatry, 19, 121–129.Google ScholarPubMed
Morton, N. E. (1955) Sequential tests for the detection of linkage. American Journal of Human Genetics, 7, 277–318.Google Scholar
Rosenthal, D., Wender, P. H., Kety, S. S., Welner, J. & Schulsinger, F. (1971) The adopted-away offspring of schizophrenics. American Journal of Psychiatry, 128, 307–311.CrossRefGoogle ScholarPubMed
Slater, E. & Cowie, V. A. (1971) The Genetics of Mental Disorders. Oxford: Oxford University Press.Google Scholar
Smeraldi, E., Bellodi, L. & Cazzullo, C. L. (1976) Further studies on the major histocompatibility complex as a genetic marker for schizophrenia. Biological Psychiatry, 11, 655–661.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders (3rd ed). New York: New York State Psychiatric Institute.Google Scholar
Stephens, D. A., Atkinson, M. W., Kay, D. W. K., Roth, M. & Garside, R. F. (1975) Psychiatric morbidity in parents and sibs of schizophrenics and non-schizophrenics. British Journal of Psychiatry, 127, 97–108.Google Scholar
Svejgaard, A. Platz, P., Ryder, L. P., Neilson, L. S. & Thomsen, M. (1975) HLA and disease association: a survey. Transplant Review, 22, 3–39.Google ScholarPubMed
Terasaki, P. I., McCelland, J. P., Park, M. S. & McCurdy, B. (1974) Microdroplet lymphocyte toxicity test. In Manuals of Tissue Typing and Techniques (eds J. P. Ray, D. B. Hare, P. D. Penderson and O. E. Kayhoe). Bethesda: National Institute of Health.Google Scholar
Thomson, G. (1981) A review of the theoretical aspects of HLA and disease association. Theroretical Population Biology, 20, 168–208.Google Scholar
Turner, W. J. (1979) Genetic markers for schizotaxia. Biological Psychiatry, 14, 177–205.Google ScholarPubMed
Watt, D. C. (1982) The search for genetic linkage in schizophrenia. British Journal of Psychiatry, 140, 532–537.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.Google Scholar
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