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Evidence for non-progressive changes in adolescent-onset schizophrenia: Follow-up magnetic resonance imaging study

  • A. C. D. James (a1), A. Javaloyes (a2), S. James (a1) and D. M. Smith (a3)

Abstract

Background

It is not clear how far brain abnormalities in early-onset schizophrenia result from progressive neurodevelopmental or neurodegenerative processes.

Aims

To investigate the hypothesis that structural brain abnormalities in adolescent-onset schizophrenia are progressive in the early phase of the illness.

Method

A magnetic resonance imaging case–control study of 16 adolescents with schizophrenia (mean age 16.6 years, s.d.=1.9 years) with a meantime of 2.7 years (s.d.=1.7 years) between measurements and 16 matched controls (average age 16.0 years, s. d.=2.0 years) with a mean time of 1.7 years (s.d.=0.5 years) between measurements.

Results

There was no evidence of progressive structural brain changes during late adolescence. Significant ventricular enlargement (greater in males) and left-sided temporal lobe changes were evident from the outset of the illness.

Conclusions

Neurodevelopmental brain abnormalities are non-progressive during late adolescence.

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Copyright

Corresponding author

A. C. D. James, Highfield Adolescent Unit, Warneford Hospital, Warneford Lane, Headington, Oxford OX3 7JX, UK

Footnotes

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Declaration of interest

Funding provided by Oxfordshire Regional Health Authority and SANE.

Footnotes

References

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Evidence for non-progressive changes in adolescent-onset schizophrenia: Follow-up magnetic resonance imaging study

  • A. C. D. James (a1), A. Javaloyes (a2), S. James (a1) and D. M. Smith (a3)
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