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Efficacy of mindfulness-based cognitive therapy in relation to prior history of depression: randomised controlled trial

  • Nicole Geschwind (a1), Frenk Peeters (a2), Marcus Huibers (a3), Jim van Os (a4) and Marieke Wichers (a2)...

Abstract

Background

There appears to be consensus that patients with only one or two prior depressive episodes do not benefit from treatment with mindfulness-based cognitive therapy (MBCT).

Aims

To investigate whether the effect of MBCT on residual depressive symptoms is contingent on the number of previous depressive episodes (trial number NTR1084).

Method

Currently non-depressed adults with residual depressive symptoms and a history of depression ($2 prior episodes: n = 71; $3 episodes: n = 59) were randomised to MBCT (n = 64) or a waiting list (control: n = 66) in an open-label, randomised controlled trial. The main outcome measured was the reduction in residual depressive symptoms (Hamilton Rating Scale for Depression, HRSD-17).

Results

Mindfulness-based cognitive therapy was superior to the control condition across subgroups (β =–0.56, P<0.001). The interaction between treatment and subgroup was not significant (β = 0.45, P = 0.16).

Conclusions

Mindfulness-based cognitive therapy reduces residual depressive symptoms irrespective of the number of previous episodes of major depression.

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Copyright

Corresponding author

Nicole Geschwind, Center for Learning and Experimental Psychology, University of Leuven, Tiensestraat 102, Box 3712, 3000 Leuven, Belgium. Email: nicole.geschwind@ppw.kuleuven.be

Footnotes

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See editorial, pp. 260–261, this issue.

Declaration of interest

F.P. has received financial compensation as an independent symposium speaker from GlaxoSmithKline, Wyeth, Astra Zeneca, Lundbeck, Eli Lilly, Servier and Janssen-Cilag. J.V.O. is/has been an unrestricted research grant holder with or has received financial compensation as an independent symposium speaker from Eli Lilly, BMS, Lundbeck, Organon, Janssen-Cilag, GlaxoSmithKline, Astra Zeneca, Pfizer and Servier, companies that have an interest in the treatment of mental health disorders.

Footnotes

References

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Efficacy of mindfulness-based cognitive therapy in relation to prior history of depression: randomised controlled trial

  • Nicole Geschwind (a1), Frenk Peeters (a2), Marcus Huibers (a3), Jim van Os (a4) and Marieke Wichers (a2)...
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