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Dementia Praecox Revisited: Age Disorientation, Mental Status, and Ventricular Enlargement

  • Terry E. Goldberg (a1), Joel E. Kleinman (a1), David G. Daniel (a1), Michael S. Myslobodsky (a1), John D. Ragland (a1) and Daniel R. Weinberger (a1)...


Thirty-nine patients with DSM–III diagnoses of schizophrenia were examined for age disorientation, an inability to produce one's correct chronological age upon request. Six patients were age-disoriented and demented (as defined by Mini-Mental State evaluation), while two patients had delusions concerning their age, but were not demented. Age-disoriented, demented patients had very large cerebral ventricles and very low Mini-Mental State scores. This group differed on the cognitive and neuroanatomic variables from other demented, but not age-disoriented, patients, as well as from non-demented patients who were age-oriented. The age-disoriented patients appeared to be at an extreme end of the dementia spectrum in schizophrenia.


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American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.
Crow, T. J. & Mitchell, W. S. (1975) Subjective age in chronic schizophrenia: evidence for a subgroup of patients with defective learning. British Journal of Psychiatry, 126, 360363.
Donnelly, E. F., Weinberger, D. R., Waldman, I. N. & Wyatt, R. J. (1980) Cognitive impairment associated with morphological brain abnormalities on computed tomography in chronic schizophrenic patients. Journal of Nervous and Mental Disease, 168, 305308.
Folstein, M. F., Folstein, S. E. & McHugh, P. (1975) Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Fox, J. H., Kaszniak, A. W. & Huckman, M. (1979) Computerized tomographic scanning not very helpful in dementia. New England Journal of Medicine, 300, 437.
Golden, C. J., Moses, J. A., Zelazowski, R., Graber, B., Zatz, L. M., Horvath, T. V. & Berger, P. A. (1980) Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics: measurement by the standardized Luria–Nebraska Neuropsychological Battery. Archives of General Psychiatry, 37, 619623.
Johnstone, E. C., Crow, T. J., Frith, C. D., Husband, J. & Kreel, L. (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. The Lancet, ii, 924926.
Johnstone, E. C., Crow, T. J., Frith, C. D., et al (1978) The dementia of dementia praecox. Acta Psychiatrica Scandinavica, 57, 305324.
Liddle, P. F. & Crow, T. J. (1984) Age disorientation in chronic schizophrenia is associated with global intellectual impairment. British Journal of Psychiatry, 144, 193199.
Shallice, T. & Evans, M. E. (1978) The involvement of the frontal lobes in cognitive estimation. Cortex, 14, 294303.
Shelton, R. C., Karson, C. N., Doran, A. R., Pickar, D., Bigelow, L. B. & Weinberger, D. R. (1988) Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical deficit in schizophrenia. American Journal of Psychiatry, 145, 154163.
Stevens, M., Crow, T. J., Bowman, M. J. & Coles, E. C. (1978) Age disorientation in schizophrenia: a constant prevalence of about 25% in a chronic mental hospital population? British Journal of Psychiatry, 133, 130136.
Synek, V. M. & Reuben, J. R. (1976). The ventricular–brain ratio using planimetric measurements of EMI scans. British Journal of Radiology, 49, 233237.
Weinberger, D. R., Torrey, E. F. & Neophytides, A. N. (1979) Lateral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry, 36, 735739.
Wyatt, R. J. (1976) Biochemistry and schizophrenia (part iv). The neuroleptics – their mechanism of action: a review of the biochemical literature. Psychopharmacology Bulletin, 12, 550.
Zatz, L. M., Jernigan, T. C. & Ahumada, A. J. Jr (1982) Changes on computed tomography with aging: intracranial fluid volume. American Journal of Neuroradiology, 3, 111.


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Dementia Praecox Revisited: Age Disorientation, Mental Status, and Ventricular Enlargement

  • Terry E. Goldberg (a1), Joel E. Kleinman (a1), David G. Daniel (a1), Michael S. Myslobodsky (a1), John D. Ragland (a1) and Daniel R. Weinberger (a1)...
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