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Cyproheptadine in Anorexia Nervosa

  • Solomon C. Goldberg (a1), Katherine A. Halmi (a2), Elke D. Eckert (a3), Regina C. Casper (a4) and John M. Davis (a5)...


In three hospitals 81 female patients satisfying rigorous diagnostic criteria for anorexia nervosa were randomly allocated to one of four treatment combinations of cyproheptadine and placebo with behaviour therapy and no behaviour therapy. Cyproheptadine was found to be effective in inducing weight gain in a subgroup of anorexia nervosa patients who (a) had a history of birth delivery complications, (b) had lost 41–52 per cent weight from norm and (c) had a history of prior outpatient treatment failure. This subgroup may represent a more severe form of anorexia nervosa.



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Blinder, B. J., Freeman, D. M. & Stunkard, A. J. (1970) Behaviour therapy of anorexia nervosa: effectiveness of activity as a reinforcer of weight gain. American Journal of Psychiatry, 126, 1093–8.
Bruch, H. (1970) Psychotherapy in primary anorexia nervosa. Journal of Nervous and Mental Diseases, 150, 5167.
Crisp, A. H. (1965) A treatment regimen for anorexia nervosa. British Journal of Psychiatry, 112, 505–12.
Dally, P. N. & Sargent, W. (1960) A new treatment of anorexia nervosa. British Medical Journal, 1, 1770–3.
Goldberg, S. C., Klerman, G. L. & Cole, J. O. (1965) Changes in schizophrenic psychopathology and ward behaviour as a function of phenothiazine treatment. British Journal of Psychiatry, 111, 120–33.
Kuhn, R. (1969) Psychopathology: ‘Pharmacotherapy and psychotherapy of anorexia nervosa’. In Psychotropic Drugs in Internal Medicine (ed. Pletscher, E.), pp. 74122. Amsterdam: Exerpta Medica Foundation.
Liebman, R., Minuchin, S. & Baker, L. (1974) An integrated treatment programme for anorexia nervosa. American Journal of Psychiatry, 131, 432–6.
Pollin, W., Stabenau, J. R., Mosher, L. & Tupin, J. (1966) Life history differences in identical twins discordant for schizophrenia. American Journal of Orthopsychiatry, 26, 492509.
Quitkin, F., Rifkin, A. & Klein, D. F. (1976) Neurologic soft signs in schizophrenia and character disorders. Archives of General Psychiatry, 33, 845–53.
Raskin, A. & Crook, T. H. (1976) The endogenous-neurotic distinction as a predictor of response to antidepressant drugs. Psychological Medicine, 6, 5970.
Rollins, N. & Blackwell, A. (1968) The treatment of anorexia nervosa in children and adolescents: stage 1. Journal of Child Psychology and Psychiatry, 9, 8191.
Russell, G. F. M. (1973) The management of anorexia nervosa. From Symposium on Anorexia Nervosa and Obesity, Royal College of Physicians of Edinburgh, 42, 4462.
Zubiate, Toledo M. (1970) Tratamiento de la anorexia nervosa con una associacion cyproheptadinavitaminas. Rev. Med. Caja Noc. Seguro Soc., 19, 147–53.

Cyproheptadine in Anorexia Nervosa

  • Solomon C. Goldberg (a1), Katherine A. Halmi (a2), Elke D. Eckert (a3), Regina C. Casper (a4) and John M. Davis (a5)...


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